vitronectin receptor
Coordinated expression of the vitronectin receptor and the urokinase type plasminogen activator receptor in metastatic melanoma cells
... Integrin alpha v beta 3 is a marker of progression in malignant melanoma. Previously we reported that human melanoma cells derived from regional lymph node metastases had increased alpha v beta 3-mediated adhesion to ...
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Thrombospondin cooperates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosis
... For example, we have reported that attachment of M to surfaces treated with Vn but not fibrinogen or type IV collagen inhibited subsequent recognition of aged neutrophils, in keeping wit[r] ...
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Vitronectin receptor antibodies inhibit infection of HeLa and A549 cells by adenovirus type 12 but not by adenovirus type 2.
... HeLa cells and A549 cells were treated in suspension with monoclonal antibodies specific for integrins cavP5 and cavl33 P1F6 and LM609, respectively, with the Ad2 penton base central fra[r] ...
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Glioblastoma expression of vitronectin and the alpha v beta 3 integrin Adhesion mechanism for transformed glial cells
... cell-associated vitronectin (5/5). In contrast, vitronectin was not detected associated with glial cells in low grade astroglial tumors (0/4), reactive astrogliosis (0/4), or in normal adult cortex and ...
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Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and IIIa
... the vitronectin receptor (VNR alpha), the fibronectin receptor (FNR alpha), and for the alpha subunit of the platelet glycoprotein IIb/IIIa complex, ...
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Binding of high molecular weight kininogen to human endothelial cells is mediated via a site within domains 2 and 3 of the urokinase receptor
... acquired receptor for prekallikrein, which, after its activation, may directly activate ...by vitronectin, anti- uPAR domain 2 and 3 antibodies and soluble, recombinant uPAR (suPAR), but not by antibody ...
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The positive role of vitronectin in radiation induced lung toxicity: the in vitro and in vivo mechanism study
... Pulmonary fibrosis is a late stage of the RILT, and is diagnosed with excessive fibroblast proliferation, collagen and extracellular matrix (ECM) deposition. Fibroblast is the key effector cells in pulmonary fibrosis, ...
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Identification and characterization of cell substratum adhesion receptors on cultured human endothelial cells
... fibronectin receptor (alpha 5/beta 1), a collagen receptor (alpha 2 beta 1), a multifunctional receptor that binds to fibronectin, collagen, and laminin (alpha 3/beta 1), as well as a receptor ...
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Validation of semaphorin 7A and ala-β-his-dipeptidase as biomarkers associated with the conversion from clinically isolated syndrome to multiple sclerosis
... In a previous proteomic study conducted by our group in pooled CSF samples, levels of apoAI, apoAIV, vitro- nectin, plasminogen, sema7A, and CNDP1 were found to be significantly different between CIS patients who ...
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The initial steps of ovarian cancer cell metastasis are mediated by MMP 2 cleavage of vitronectin and fibronectin
... peritoneum, and in vivo to mouse peritoneum and omentum. Absence of MMP-2 in the host did not alter OvCa adhesion, as determined utilizing mice harboring homozygous null mutations in either the Mmp2 or Mmp9 genes. ...
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Growth-factor reduced Matrigel source influences stem cell derived brain microvascular endothelial cell barrier properties
... In their previous studies, Shusta and colleagues have established the method and demonstrated the ability to obtain BMECs from both embryonic and iPS stem cell lines with variable outcomes [7, 8, 11]. They used ...
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Amphibian Bufo arenarum vitronectin like protein: its localization during oogenesis
... Int J De\' BioI 411 997 ]008 (] 996) 997 Original Article Amphibian Bufo arenarum vitronectin like protein its localization during oogenesis MANUEL J AYBAR, SUSANA B GENTA, EVELINA I VILLECCO, ALICIA[.] ...
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Coordinate regulation of fibronectin matrix assembly by the plasminogen activator system and vitronectin in human osteosarcoma cells
... required vitronectin, MG-63 cells were seeded overnight onto wells coated with either fibronectin or ...onto vitronectin-coated substrates (Figure ...in vitronectin is within the amino terminal ...
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Inhibition of the Membrane Attack Complex by Dengue Virus NS1 through Interaction with Vitronectin and Terminal Complement Proteins
... regulator vitronectin (VN) as a novel DENV NS1 binding partner, and the NS1-VN complex was detected in plasmas from DENV-infected patients, suggesting that this interaction occurs during DENV ...
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The structure and function of the CGRP receptor
... different receptor regions (Sheikh et al., 1996). Selected receptor residues are substituted with histidine and are activated in the presence or absence of Zn 2+ ...the receptor to activate the G ...
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Expression profiles of genes involved in TLRs and NLRs signaling pathways of water buffaloes infected with Fasciola gigantica
... Toll-like receptor 1 TLR2 Toll-like receptor 2 TLR3 Toll-like receptor 3 TLR4 Toll-like receptor 4 TLR5 Toll-like receptor 5 TLR6 Toll-like receptor 6 TLR7 Toll-like ...
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A novel role of vitronectin in promoting survival of mesenchymal stem cells under serum deprivation stress
... Immunolabeling of control and serum-deprived WJ- MSCs were performed as per standard protocol. WJ- MSCs cultured on glass coverslips, under control and serum-deprived conditions, and were fixed in 4% PFA for 20 min at ...
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Mechanisms of greater cardiomyocyte functions on conductive nanoengineered composites for cardiovascular applications
... Adsorption of proteins on the sample surfaces was accomplished using fibronectin and vitronectin. First, all the study samples were rinsed with phosphate-buffered solution (8 g NaCl, 0.2 g KCL, 1.5 g Na 2 HPO 4 , ...
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The cellular microenvironment modulates the role of PAI 1 and vitronectin in mediating cell matrix interactions
... ample, vitronectin was found to promote migration of smooth muscle cells and keratinocytes ...collagen receptor α2β1 exhi- bited high expression in both the cell ...by vitronectin alone or in complex ...
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Mechanical strain of rat vascular smooth muscle cells is sensed by specific extracellular matrix/integrin interactions
... coated at varying densities with elastin, laminin, type I collagen, fibronectin, or vitronectin. Strain was applied by cyclic application of a vacuum under the dishes. Cells adhered, spread, and proliferated on ...
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