von Willebrand factor activity
Factor VIII/von Willebrand factor protein Galactose a cryptic determinant of von Willebrand factor activity
... asialo Factor VIII/von Willebrand factor protein with galactose oxidase resulted in a progressive loss of von Willebrand factor activity with no effect on ...
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Comorbidities associated with higher von Willebrand factor (VWF) levels may explain the age-related increase of VWF in von Willebrand disease
... VWF activity (measured by the VWF monoclonal antibody assay; VWF:Ab) and FVIII coagulant activity (FVIII:C) were centrally measured at the Erasmus University Medical ...binding activity of VWF to ...
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Key words
... Von Willebrand factor, regarded as a good marker of endothelial function, is a procoagulant in coagulation activation [8, ...Increased von Willebrand factor activity has ...
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Disulfide Bonds and the Quaternary Structure of Factor VIII/von Willebrand Factor
... cofactor activity and Factor VIII procoagulant ...of von Willebrand factor activity. In contrast, Factor VIII activity was unchanged by ...
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Studies of the human factor VIII/von Willebrand factor protein III Qualitative defects in von Willebrand's disease
... VIII/von Willebrand factor protein had markedly reduced von Willebrand factor activity in a ristocetin ...of Factor VIII/von Willebrand factor ...
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Human von Willebrand factor/factor VIII concentrates in the management of pediatric patients with von Willebrand disease/hemophilia A
... In type 2M VWD, VWF multimer distribution is normal, but platelet-dependent VWF activities (VWF:RCo and von Willebrand factor collagen binding activity [VWF:CB]) are disproportionally reduced ...
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Von Willebrand factor propeptide as a marker of disease activity in systemic sclerosis (scleroderma)
... Plasma concentrations of vWf in 44 SSc patients were higher than the corresponding concentrations of propep- tide (P < 0.01; Supplementary Fig. 1). One outlier in vWf, with a plasma concentration nearly three times ...
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Carbohydrate moiety of von Willebrand factor is not necessary for maintaining multimeric structure and ristocetin cofactor activity but protects from proteolytic degradation
... cofactor activity of von Willebrand factor, we have removed up to 83% of total hexose by sequential treatment of the molecule with endo-beta-N-acetyl-glucosaminidase F (endo F), neuraminidase, ...
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Intracellular trafficking of factor VIII to von Willebrand factor storage granules
... FVIII activity assays that the biosynthesis of FVIII occurred ...has activity similar to that of transfected COS-7–expressed FVIII, although the transfection efficiency of the AtT-20 cells is markedly ...
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N acetylcysteine reduces the size and activity of von Willebrand factor in human plasma and mice
... Results We examined whether, by analogy with its effect on polymeric mucins, NAC could reduce the size and reactivity of vWF, using purified human vWF, human plasma, and wild-type and AD[r] ...
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Salvage therapy with high dose Intravenous Immunoglobulins in acquired Von Willebrand Syndrome and unresponsive severe intestinal bleeding
... abnormalities: factor VIII co- agulant activity (FVIII: C) was 10% of normal pooled plasma, von Willebrand factor antigen (VWF Ag) was 7%, von Willebrand factor ...
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Inactivation of human factor VIII by activated protein C Cofactor activity of protein S and protective effect of von Willebrand factor
... endogenous von Willebrand factor, resulting in a complete protection against APC (4 ...severe von Willebrand's disease, we could vary the amount of von Willebrand ...of ...
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Procoagulatory changes induced by head-up tilt test in patients with syncope: observational study
... The activity of von Willebrand factor (VWF:GP1bA) was analysed with an immunoassay based on an anti- body against glycoprotein 1b (GP1b) and a GP1b con- struct that binds VWF in the sample ...
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Structural basis of von Willebrand factor binding to platelet glycoprotein Ib and collagen Effects of disulfide reduction and limited proteolysis of polymeric von Willebrand factor
... requirements for vWF binding with platelet glycoprotein Ib (GpIb), heparin, and collagen and have shown that fragments derived from large vWF multimers retain biologic activity. We have shown that a 440,000-D ...
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... Plasma von Willebrand factor (vWF) activity, serum albumin, glucose, total cholesterol, triglycerides and lipoprotein (a) levels, as well as serum level of homocysteine, parathyroid hormone ...
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Effect of a 3-Week Low-Calorie Diet and Balneological Treatment on Selected Coagulation Parameters in Morbidly Obese Patients
... and activity of plas- ma coagulation factors such as hyperfibrinogene- mia, VII, VIII and von Willebrand factors, platelet hyperactivity and, indirectly, endothelium damage as an independent ...
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von Willebrand factor
... ganelles for regulated release—Weibel-Palade bodies in endothelial cells and a -granules in megakaryocytes (or plate- lets after thrombocytopoiesis)—or constitutively secreted. The latter pathway is operative only in ...
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Functional domains on von Willebrand factor Recognition of discrete tryptic fragments by monoclonal antibodies that inhibit interaction of von Willebrand factor with platelets and with collagen
... the von Willebrand factor (VWF) moiety of the Factor VIII-von Willebrand factor complex (FVIII-VWF), one interacting with blood platelets, and one interacting with vessel ...
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Thrombin induced exposure and prostacyclin inhibition of the receptor for factor VIII/von Willebrand factor on human platelets
... concentration-dependent binding of 125I-labeled F. VIIIVWF in a steady-state system. The binding induced by thrombin was specific because it was inhibited by a 100-fold molar excess of unlabeled F. VIIIVWF factor, ...
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Binding of Staphylococcus aureus Protein A to von Willebrand Factor Is Regulated by Mechanical Force
... ABSTRACT Binding of Staphylococcus aureus to the large plasma glycoprotein von Willebrand factor (vWF) is controlled by hydrodynamic flow conditions. Currently, we know little about the molecular ...
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