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Warburg effect

Ovarian clear cell carcinoma meets metabolism; HNF-1β confers survival benefits through the Warburg effect and ROS reduction

Ovarian clear cell carcinoma meets metabolism; HNF-1β confers survival benefits through the Warburg effect and ROS reduction

... In addition to supporting cell proliferation, the metabolism shift from oxidative phosphorylation to aerobic glycolysis confers another important advantage for cancer cells, namely, cell survival [66, 67]. Suppression of ...

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MtDNA depleted PC3 cells exhibit Warburg effect and cancer stem cell features

MtDNA depleted PC3 cells exhibit Warburg effect and cancer stem cell features

... like features reported previously in the human pluripotent cells [53–56]. We did find that the cells had perinuclear located mitochondria, and the transcriptome profiling of mitochondrial dynamic related genes also ...

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RRAD inhibits the Warburg effect through negative regulation of the NF-κB signaling

RRAD inhibits the Warburg effect through negative regulation of the NF-κB signaling

... [11-15]. Furthermore, the down-regulation of RRAD was reported to be associated with tumor progression and poor prognosis in cancer patients [11-15]. Recently, RRAD was identified as p53-regulated gene, which mediates ...

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A new mechanism of trastuzumab resistance in gastric cancer: MACC1 promotes the Warburg effect via activation of the PI3K/AKT signaling pathway

A new mechanism of trastuzumab resistance in gastric cancer: MACC1 promotes the Warburg effect via activation of the PI3K/AKT signaling pathway

... the Warburg effect may contribute to chemoresistance or therapy failure in patients with GC, making the disease difficult to cure using a single ...the Warburg effect improves the response to ...

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Noscapine Induces Apoptosis in Human Colon Cancer Cells by Regulating Mitochondrial Damage and Warburg Effect via PTEN/PI3K/mTOR Signaling Pathway

<p>Noscapine Induces Apoptosis in Human Colon Cancer Cells by Regulating Mitochondrial Damage and Warburg Effect via PTEN/PI3K/mTOR Signaling Pathway</p>

... toxic effect in animals and ...the Warburg effect, wherein cancer cells prefer- entially convert glucose into ...the Warburg effect is related to changes in the tumor microenvironment, ...

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Mitochondrion-mediated iron accumulation promotes carcinogenesis and Warburg effect through reactive oxygen species in osteosarcoma

Mitochondrion-mediated iron accumulation promotes carcinogenesis and Warburg effect through reactive oxygen species in osteosarcoma

... and Warburg effect of osteosarcoma ...of Warburg key enzymes HK2 and Glut1, and affected AMPK/mTORC1 signaling ...and Warburg effect of osteosar- coma ...Mitoferrin, Warburg, ...

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PTBP1-associated microRNA-1 and -133b suppress the Warburg effect in colorectal tumors

PTBP1-associated microRNA-1 and -133b suppress the Warburg effect in colorectal tumors

... Earlier we reported that miR-124 suppresses the Warburg effect via the miR-124/PTBP1/PKMs axis by binding to PTBP1 [19]. The miRNA database indicated that PTBP1 also has predicted binding sites for miR-1 ...

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Analysis of Key Genes Regulating the Warburg Effect in Patients with Gastrointestinal Cancers and Selective Inhibition of This Metabolic Pathway in Liver Cancer Cells

<p>Analysis of Key Genes Regulating the Warburg Effect in Patients with Gastrointestinal Cancers and Selective Inhibition of This Metabolic Pathway in Liver Cancer Cells</p>

... the effect of CUEDC2 on glycolysis in HCC cells has not been ...the Warburg effect in gastrointestinal cancers, especially in liver cancer, has not been systematically ...studying Warburg ...

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RRAD suppresses the Warburg effect by downregulating ACTG1 in hepatocellular carcinoma

<p>RRAD suppresses the Warburg effect by downregulating ACTG1 in hepatocellular carcinoma</p>

... Conclusion: We have shown that RRAD exhibits a tumor-suppressing role in HCC by downregulating glucose metabolism and ACTG1 expression, thus lowering cell proliferation, arresting the cell cycle, and increasing ...

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PDHA1 Gene Knockout In Human Esophageal Squamous Cancer Cells Resulted In Greater Warburg Effect And Aggressive Features In Vitro And In Vivo

<p><em>PDHA1</em> Gene Knockout In Human Esophageal Squamous Cancer Cells Resulted In Greater Warburg Effect And Aggressive Features In Vitro And In Vivo</p>

... Methods And Results: In this study, a KYSE450 PDHA1 knockout (KO) cell line of esophageal cancer was established by CRISPR/Cas9 technology. Then, the glycose metabo- lism, cell proliferation and migration abilities, ...

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Crosstalk between the Warburg effect, redox regulation and autophagy induction in tumourigenesis

Crosstalk between the Warburg effect, redox regulation and autophagy induction in tumourigenesis

... The Warburg effect describes a hallmark of cancer where glycolysis results in lactate production even in aerobic conditions [1, 3, ...Furthermore, Warburg reported that tumourigenic cells exhibit ...

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Wild-type IDH2 promotes the Warburg effect and tumor growth through HIF1α in lung cancer

Wild-type IDH2 promotes the Warburg effect and tumor growth through HIF1α in lung cancer

... curative resection of hepatocellular carcinoma [28]. Here we reported that wild-type IDH2 is highly expressed in multiple cancers, especially in lung cancer, and this high level of IDH2 correlates with poor survival. We ...

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Amyloid beta resistance and the Warburg effect: Re-examining Alzheimer's disease

Amyloid beta resistance and the Warburg effect: Re-examining Alzheimer's disease

... 2007; Warburg, 1956). This phenomenon is termed the Warburg effect, or aerobic glycolysis, and is driven by hypoxia inducible factor 1 α subunit (HIF-1α) (Kim et ...

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Nuclear Receptors and the Warburg effect in cancer

Nuclear Receptors and the Warburg effect in cancer

... Otto Warburg, (now termed aerobic glycolysis) is a key feature of many cancer ...the Warburg effect, is so widespread and palpable that it has been used to identify primary and metastatic lesions ...

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Warburg effect hypothesis in autism Spectrum disorders

Warburg effect hypothesis in autism Spectrum disorders

... Metabolic enzymes are modified by the dysregulation of the canonical WNT/β-catenin pathway. Upregulation of WNT/β-catenin signaling leads to activation of pyru- vate dehydrogenase kinase-1 (PDK-1), which decreases the ...

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Cancer proliferation and therapy: the Warburg effect and quantum metabolism

Cancer proliferation and therapy: the Warburg effect and quantum metabolism

... the Warburg effect, and (b) propose methods based on entropic principles of natural selection for regulating the incidence of OxPhos and glycolysis in cancer ...

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Cyclin G2 Inhibits the Warburg Effect and Tumour Progression by Suppressing LDHA Phosphorylation in Glioma

Cyclin G2 Inhibits the Warburg Effect and Tumour Progression by Suppressing LDHA Phosphorylation in Glioma

... GBM, like most cancers, utilize aerobic glycolysis as the primary supplier of ATP [11, 48]. Although several therapies are currently in use, including small-molecule kinase inhibitors, anti-vascular endothelial growth ...

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Simultaneous characterization of tumor cellularity and the Warburg effect with PET, MRI and hyperpolarized 13C-MRSI

Simultaneous characterization of tumor cellularity and the Warburg effect with PET, MRI and hyperpolarized 13C-MRSI

... the Warburg effect-one of the hallmarks of tumors-can be measured non-invasively with this emerging ...the effect of varying tumor cellularity on image-derived metabolic ...

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Fructose contributes to the Warburg effect for cancer growth

Fructose contributes to the Warburg effect for cancer growth

... the Warburg effect to preferentially downregulate mitochondrial respiration and increases aerobic glycolysis that may aid metastases that initially have low oxygen ...

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HMGB2 is associated with malignancy and regulates Warburg effect by targeting LDHB and FBP1 in breast cancer

HMGB2 is associated with malignancy and regulates Warburg effect by targeting LDHB and FBP1 in breast cancer

... the Warburg effect in breast cancer ...glycolysis.The Warburg effect, also known as aerobic glycolysis, is a shift from oxidative phosphorylation to glycolysis, and is considered to be a ...

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