Wiskott-Aldrich syndrome protein
Neural Wiskott Aldrich syndrome protein modulates Wnt signaling and is required for hair follicle cycling in mice
... function. Wiskott-Aldrich syndrome family proteins act downstream of these GTPases, control- ling actin assembly and cytoskeletal reorganization, but their role in epithelial cells has not been ...
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Wiskott-Aldrich Syndrome Protein Is Needed for Vaccinia Virus Pathogenesis
... Although smallpox has been eradicated, little is known of the mechanisms responsible for the high mortality rate due to this disease (9, 21). Since vaccination has been discontinued (9), recent acts of bioterrorism and ...
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The Novel Adaptor Protein, Mti1p, and Vrp1p, a Homolog of Wiskott-Aldrich Syndrome Protein-Interacting Protein (WIP), May Antagonistically Regulate Type I Myosins in Saccharomyces cerevisiae
... mammalian Wiskott-Aldrich syndrome protein (WASP), and Vrp1p, a homolog of WASP-interacting protein ...adaptor protein, Mti1p (Myosin tail region-interacting protein), ...
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Polarized Hyphal Growth in Candida albicans Requires the Wiskott-Aldrich Syndrome Protein Homolog Wal1p
... the Wiskott-Aldrich syndrome protein (WASP) homolog deleted do not form hyphae under all inducing conditions ...fluorescent protein (GFP)-tagged Wal1p showed patch-like localization in ...
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Identification and characterisation of the interaction between Wiskott-Aldrich syndrome protein (WASP) and c-Src kinases
... the protein to the plasma membrane where these kinases are predominately located (Resh, ..."receptor" protein is necessary for mediating c- Src membrane binding and that binding is not merely a ...
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Nuclear Wiskott–Aldrich syndrome protein co-regulates T cell factor 1-mediated transcription in T cells
... TCF12 protein when compared to WT thymocytes, perhaps indicating that a fraction of WT WASp resides in an autoinhibited conformation that prevents over- activation of ...nuclear– protein complex containing ...
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Studies of the expression of the Wiskott Aldrich syndrome protein
... confirm protein transfer and visualize molecular weight markers, PVDF blots were stained with Coomassie blue, and nitrocellulose blots were stained with colloidal gold (Bio-Rad Laboratories, Hercules, ...fusion ...
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Wiskott Aldrich syndrome protein is required for regulatory T cell homeostasis
... Wiskott-Aldrich syndrome (WAS) is an X-linked immunodeficiency disorder characterized by opportunistic, viral, and bacterial infections due to abnormal lymphocyte ...WAS protein (WASp) ...
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Mycolactone activation of Wiskott Aldrich syndrome proteins underpins Buruli ulcer formation
... identify Wiskott-Aldrich syndrome protein (WASP) and neural WASP (N-WASP) as molecular targets of ...complex syndrome of immune defects, whereas N-WASP is more widely expressed ...
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Second site mutation in the Wiskott Aldrich syndrome (WAS) protein gene causes somatic mosaicism in two WAS siblings
... with Wiskott-Aldrich syndrome ...WAS protein (WASP) gene, which results in frameshift and abrogates protein ...mutant protein encoded by the second-site mutation was expressed ...
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Lentiviral mediated gene therapy restores B cell tolerance in Wiskott Aldrich syndrome patients
... WAS protein deficiency (WASp deficiency) affects the establishment of B cell tolerance by testing the reactivity of recombinant antibodies isolated from single B cells from 4 WAS patients before and after gene ...
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Hypercatabolism of IgG, IgA, IgM, and albumin in the Wiskott Aldrich syndrome: A unique disorder of serum protein metabolism
... shortened with a half-time of 7.5 days for IgG (normal 22.9 ±4 SD), 3.0 days for IgA (normal 5.8 ±1), 5.0 days for IgM (normal 10.1 ±2.1), and 8.6 days for albumin (normal 17, range 13- 20); the fractional catabolic ...
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Effect of omega-3 polyunsaturated fatty acids on the cytoskeleton: an open-label intervention study
... of protein fibers in the ...immunodeficiency syndrome, Wiskott - Aldrich syndrome (WAS), cancer or liver cir- rhosis have now been associated with abnormalities in cytoskeleton proteins ...
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Evidence for defective transmembrane signaling in B cells from patients with Wiskott Aldrich syndrome
... disorder, Wiskott-Aldrich syndrome (WAS), fail to produce antibodies in response to stimulation with polysaccharides and other type-2 T cell-independent ...As protein tyrosine phosphorylation ...
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A Novel Site Mutation in A Wiskott-Aldrich Syndrome Boy: A Case Report
... For invariant natural killer T (iNKT) cells, WASP is required for their maturation and activation [21]. On the other hand, WASP- expressing cells were noticed present mainly CD56+ NK cells and CD8+ T cells [22]. At the ...
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Dendritic cell defects in Wiskott-Aldrich Syndrome
... mutant protein can be o f normal length (65kD) but low expression, truncated or ...f protein correlation with clinical phenotype are warranted, although these will need to address functionality o f the ...
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Wiskott–Aldrich syndrome: diagnosis, current management, and emerging treatments
... WASp-interacting protein, a binding partner of WASp that serves to stabilize and prevent degradation of WASp, has been ...WASp-interacting protein may prove useful and clinically beneficial in patients with ...
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Clinical and Molecular Characters of a Yemeni Child with Wiskott Aldrich Syndrome
... Wiskott-Aldrich Syndrome is an x-linked immunodeficiency condition cha- racterized by microthrombocytopenia, eczema and recurrent ...the Wiskott Aldrich Protein (WASP) ...
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Autoimmunity in Wiskott-Aldrich Syndrome: Risk Factors, Clinical Features, and Outcome in a Single-Center Cohort of 55 Patients
... extremely variable. Some very young patients, younger than 2 years, had IgM values more than the mean ⫹ 2 SD, but such high levels were not detected in children older than 5 years. The reasons for the link between high ...
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Understanding the Body Paragraph: A Handbook for EFL Teachers & Students
... The Wiskott-Aldrich Foundation found that on average, patients and parents report similar QoL scores across all 4 domains, and that psychosocial QoL scores are significantly lower than physical QoL ...
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