X linked inhibitor of apoptosis
CXC receptor 2 knockout genotype increases X linked inhibitor of apoptosis protein and protects mice from acetaminophen hepatotoxicity
... of apoptosis in CXCR2 knockout mice versus wild-type mice; there were no differences seen in hepatocyte proliferation in wild-type mice versus knockout mice after this ...of apoptosis in the knockout mice ...
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X-linked inhibitor of apoptosis protein accelerates migration by inducing epithelial–mesenchymal transition through TGF-β signaling pathway in esophageal cancer cells
... of apoptosis proteins (IAPs) are potentially involved in multiple cellular signaling pathways including cell death, cell cycle, cell migration, immunity, inflamma- tion [4, ...5]. X-linked ...
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MicroRNA-24 inhibits growth, induces apoptosis, and reverses radioresistance in laryngeal squamous cell carcinoma by targeting X-linked inhibitor of apoptosis protein
... growth, apoptosis, and radiosensitivity of LSCC ...of X-linked inhibitor of apoptosis protein (XIAP) mRNA and protein, cleaved or total caspase-3, and cleaved or total PARP protein were ...
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X-linked inhibitor of apoptosis positive nuclear labeling: a new independent prognostic biomarker of breast invasive ductal carcinoma
... rate. On the other hand, overexpression of oncogene HER2 contributed to breast carcinogenesis. So, it’s not difficult for us to understand that apoptosis index was positively correlated with HER2 protein ...
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MicroRNA-381 enhances radiosensitivity in esophageal squamous cell carcinoma by targeting X-linked inhibitor of apoptosis protein
... the inhibitor- of-apoptosis family, is an inhibitor of apoptotic cell death that protects cells by caspase-dependent and caspase-independent ...
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Targeting bone morphogenetic protein receptor 2 sensitizes lung cancer cells to TRAIL by increasing cytosolic Smac/DIABLO and the downregulation of X-linked inhibitor of apoptosis protein
... the inhibitor of apoptosis proteins cIAP1, cIAP2 and ...caspase inhibitor VAD significantly inhibited cell death induced by JL5 in combination with AEG ...
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IκB Kinase ε-Dependent Phosphorylation and Degradation of X-Linked Inhibitor of Apoptosis Sensitizes Cells to Virus-Induced Apoptosis
... of autoubiquitination in XIAP were previously identified as Lys322 and Lys328, and the mutation of these residues abrogated XIAP autoubiquitination (58). Both wtXIAP and the XIAP K322/ 328R mutant were phosphorylated in ...
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The Targeted SMAC Mimetic SW IV-134 is a strong enhancer of standard chemotherapy in pancreatic cancer
... evade apoptosis as they acquire resistance to conventional chemotherapy ...The inhibitor of apoptosis proteins (IAP) frequently contribute to drug resistance via block- ade of caspase activation ...
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Role of Smac/DIABLO in cancer progression
... with inhibitor of apoptosis proteins (IAPs) ...by X-linked inhibitor of apoptosis (XIAP), cellular IAP-1 (c-IAP1), cel- lular IAP-2 (c-IAP2), Testis specific IAP (Ts-IAP), ...
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Original Article Inhibition of papillary thyroid carcinoma growth by miR-200c via suppressing XIAP expression
... As a member of miR-200 family, miR-200c has close correlation with colorectal carcinoma [8], prostate cancer [9], thymic lymphoma [10], and breast cancer [11]. Its relationship with PTC, however, has not been reported. ...
7
Site-specific gene expression patterns in oral cancer
... and apoptosis/stress response genes (Hif-1-alpha, Glut 1, CA IX, caspase, hsp70, XIAP) were investigated by means of ...cancer. X-linked inhibitor of apoptosis (XIAP) showed a ...
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Protease nexin 1 induces apoptosis of prostate tumor cells through inhibition of X-chromosome-linked inhibitor of apoptosis protein
... its signal from the extracellular matrix (ECM) was examined. We found that uPA activity, an ECM target of PN1, correlated with XIAP mRNA levels. This is in accordance with a previous study that implicates uPA in the ...
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Molecular genetics of X-linked deafness
... This work was funded by the Medical Research Council and performed in the Molecular Genetics Unit at the Institute of Child Health, London. I would like to thank all the members of the laboratory but particularly Jess ...
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Management of X linked adrenoleukodystrophy in Morocco: actual situation
... of X-ALD was made basing on clinical manifestations, cerebral MRI, general biologic assessment, cortisol and ACTH ...of X-ALD ...case X-ALD, we scheduled a genetic consultation to explain the disease ...
6
X-linked disorders with cerebellar dysgenesis
... dilatation of the lateral cerebral ventricles and mild corti- cal atrophy was also present. A similar clinico-radiologi- cal phenotype (Figure 1a-c) was found in the affected males of a family carrying a single ...
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Effects of concentration of amyloid β (Aβ) on viability of cultured retinal pigment epithelial cells
... when apoptosis occurs through the caspase pathway, these results suggest that the apoptosis is mediated by caspase 9, and it is related to the death of retinal pigment epithelial cells caused by high con- ...
8
Givinostat, a type II histone deacetylase inhibitor, induces potent caspase-dependent apoptosis in human lymphoblastic leukemia
... of apoptosis of Givinostat on these two cell lines in hope to find the ...the apoptosis was prominently induced in SUP-B15 but not in ...initiating apoptosis through induction of p21 and PUMA, its ...
9
Update on oral-facial-digital syndromes (OFDS)
... an X-linked dominant condition with male lethality, which usually occurs during the first and second trimester of pregnancy ...the X chromosome ...
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Restimulation induced apoptosis of T cells is impaired in patients with X linked lymphoproliferative disease caused by SAP deficiency
... Similarly, apoptosis was also re- established in XLP Pt4 T cells treated with the weaker OKT3 mAb if it was hyper-cross-linked with high-capacity Fc binding protein A (Figure ...
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The molecular basis of X-linked agammaglobulinemia
... The pathological mutation in family P was shown, in this study, to be a G to T transversion at nucleotide 2038 o f the BTK gene (Chapter 5, patient AP). The mutation was detected by an SSCP band shift in the smaller ...
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