X-linked Inhibitor of Apoptosis (XIAP)
Site-specific gene expression patterns in oral cancer
... and apoptosis/stress response genes (Hif-1-alpha, Glut 1, CA IX, caspase, hsp70, XIAP) were investigated by means of ...cancer. X-linked inhibitor of apoptosis (XIAP) ...
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X-Linked Lymphoproliferative Syndrome and Common Variable Immunodeficiency May Not Be Differentiated by SH2D1A and XIAP/BIRC4 Genes Sequence Analysis
... The X-linked lymphoproliferative syndrome (XLP) is a rare, inherited immunodeficiency characterized by recurrent episodes of hemophagocytic lymphohistiocytosis, hypogammaglobulinemia, and/or ...Recently, ...
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Role of Smac/DIABLO in cancer progression
... with inhibitor of apoptosis proteins (IAPs) ...by X-linked inhibitor of apoptosis (XIAP), cellular IAP-1 (c-IAP1), cel- lular IAP-2 (c-IAP2), Testis specific IAP (Ts-IAP), ...
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Original Article Inhibition of papillary thyroid carcinoma growth by miR-200c via suppressing XIAP expression
... Abstract: Papillary thyroid carcinoma (PTC) is a common malignant tumor of thyroid tissues that affects people’s health. The occurrence of PTC has been found to be related with abnormal expression of microRNA (miR). ...
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X-linked inhibitor of apoptosis protein accelerates migration by inducing epithelial–mesenchymal transition through TGF-β signaling pathway in esophageal cancer cells
... dissociation inhibitor (RhoGDI) via its RING domain [24, ...signal, XIAP was recruited to mono-ubiquitinates TLE and liberated TCF to form transcription complexes with β-catenin to active Wnt signal which ...
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MicroRNA-381 enhances radiosensitivity in esophageal squamous cell carcinoma by targeting X-linked inhibitor of apoptosis protein
... of XIAP mRNA. However, how does XIAP play a role in ESCC radioresistance requires further ...downregulated XIAP protein levels in ...with XIAP expression. More importantly, knockdown of ...
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Protease nexin 1 induces apoptosis of prostate tumor cells through inhibition of X-chromosome-linked inhibitor of apoptosis protein
... Elevated XIAP has been observed in prostate cancer ...and XIAP in the more advanced prostate cancers (Gleason 8–10), and that PN1 protein is concurrently decreased (Figure ...6A). XIAP and p65 ...
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IκB Kinase ε-Dependent Phosphorylation and Degradation of X-Linked Inhibitor of Apoptosis Sensitizes Cells to Virus-Induced Apoptosis
... paramyxovirus-induced apoptosis is blocked and persistently in- fected IRF3 ⫺/⫺ cells continuously produce infectious virus with- out undergoing apoptosis ...and apoptosis (9). We found that ...
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Targeting bone morphogenetic protein receptor 2 sensitizes lung cancer cells to TRAIL by increasing cytosolic Smac/DIABLO and the downregulation of X-linked inhibitor of apoptosis protein
... ID1, XIAP, and TAK1, and induce more cell death of lung cancer cell lines than the BMP inhibitors DMH1 and LDN ...decreased XIAP expression and increased cyto- solic Smac/DIABLO and cytochrome ...
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MicroRNA-24 inhibits growth, induces apoptosis, and reverses radioresistance in laryngeal squamous cell carcinoma by targeting X-linked inhibitor of apoptosis protein
... of XIAP mRNA. To test directly whether XIAP is a target of miR-24, we constructed a luciferase reporter (pLUC/XIAP/ 3′-UTR-wt) in which the XIAP/3′-UTR nucleotides com- plementary to miR-24 ...
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X-linked inhibitor of apoptosis positive nuclear labeling: a new independent prognostic biomarker of breast invasive ductal carcinoma
... of XIAP were more higher than Smac in breast IDC, and semi-quantitation analysis of western blot detection proved it ...between XIAP and Smac contributed to progression of renal cell carcinoma and ...
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CXC receptor 2 knockout genotype increases X linked inhibitor of apoptosis protein and protects mice from acetaminophen hepatotoxicity
... cellular inhibitor of apoptosis protein; CXCR2, chemokine (C-X-C motif ) receptor 2; ELISA, enzyme-linked immunosorbent assay; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; GSH, ...
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Original Article miR-320 inhibits multidrug resistance of osteosarcoma cells to methotrexate by targeting XIAP
... and X-linked inhibitor of apoptosis protein (XIAP) was observed in established OS MDR cell lines by real-time polymerase chain reaction ...knockdown XIAP sensitized SaOS-2/R and ...
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The Targeted SMAC Mimetic SW IV-134 is a strong enhancer of standard chemotherapy in pancreatic cancer
... evade apoptosis as they acquire resistance to conventional chemotherapy ...The inhibitor of apoptosis proteins (IAP) frequently contribute to drug resistance via block- ade of caspase activation ...
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Original Article MiR-497 induces hepatocellular carcinoma cell LM3 apoptosis through downregulating XIAP
... Cell apoptosis is an autonomous cell death reg- ulated by multiple ...genes. Apoptosis blockage is closely related to a variety of tumors occur- ...rence. Inhibitor of apoptosis protein (IAP) ...
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Induction of G2M Arrest by Flavokawain A, A Kava Chalcone, Increases the Responsiveness of HER2 Overexpressing Breast Cancer Cells to Herceptin
... inducing apoptosis in HER2 overexpressing breast cancer cell lines by increasing the expression of proapoptotic proteins Bim and BAX and decreasing anti-apoptotic proteins ...Bcl- X/L , XIAP, and ...
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HUHS1015 PROMOTES AUTOPHAGIC XIAP DEGRADATION TO INDUCE APOPTOSIS OF GASTROINTESTINAL CANCER CELLS
... AGGTCCACCACCCTGTTGCTGTAG. Total RNAs were purified from cells using a Sepasol-RNA I Super kit (Nacalai, Kyoto, Japan) and treated with RNase-free DNase I (2 units) at 37 °C for 30 min. Then, random primers, dNTP, 10× RT ...
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Original Article Zinc finger protein x-linked (ZFX) contributes to patient prognosis, cell proliferation and apoptosis in human laryngeal squamous cell carcinoma
... protein, X-linked (ZFX) gene locus on the human X chromosome is structurally similar to the zinc finger protein, Y-linked ...protein X-linked (ZFX) in human ...
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Postmitochondrial regulation of apoptosis in neurons and cancer cells
... While all cancers must develop mutations that allow them to inhibit the apoptotic pathway, the mechanisms by which cancers do this are as diverse as the cancers themselves. A better understanding of how the apoptotic ...
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Transformation of SV40-immortalized human uroepithelial cells by 3-methylcholanthrene increases IFN- and Large T Antigen-induced transcripts
... of apoptosis (DR1, HSIAH2, IAP3, DAP1), known to act either as decoys that bind and inactivate apoptotic ligands, or act upstream of the ...of apoptosis signaling and checkpoint control, there were many ...
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