Xenograft tumors
Inhibition of leukemic cells by valproic acid, an HDAC inhibitor, in xenograft tumors
... In conclusion, our study confirms that valproic acid significantly suppresses growth of Kasumi-1 cell xenograft tumors in nude mice via cell cycle arrest. The antitumor activity of valproic acid is possibly ...
8
The suppression of FOXM1 and its targets in breast cancer xenograft tumors by siRNA
... subcutaneous xenograft tumors upon intratumoral ...within tumors for at least 24 hours, as determined by the retention of tumor-associated fluorescence over time (Figure 1, ...in tumors and ...
9
Fisetin, aphytochemical, potentiates sorafenib-induced apoptosis and abrogates tumor growth in athymic nude mice implanted with BRAF-mutated melanoma cells
... Melanoma is the most deadly form of cutaneous malignancy, and its incidence rates are rising worldwide. In melanoma, constitutive activation of the BRAF/MEK/ ERK (MAPK) and PI3K/AKT/mTOR (PI3K) signaling pathways plays a ...
16
Tumor-targeting, Systemically Delivered Antisense HER-2 Chemosensitizes Human Breast Cancer Xenografts Irrespective of HER-2 Levels
... MDA-MB-435 xenograft tumors that have a low level of HER-2 expression, to the effects of the drug docetaxel (Taxotere), resulting in significant inhibition of tumor growth during and even after the end of ...
12
miR-448 targets IDO1 and regulates CD8+ T cell response in human colon cancer
... a Average growth curves of subcutaneous xenograft tumors in BALB/c mice after inoculation of CT26 cells with stable IDO1 overexpression (pLenti-IDO1) or with vector control (pLenti-Vecto[r] ...
14
Patient-derived xenografts of different grade gliomas retain the heterogeneous histological and genetic features of human gliomas
... mary tumors and corresponding xenograft tumors and therefore PDX models currently represent the most reliable models in tumor biological research and pre- clinical studies [11, 24, ...patient ...
12
<p>CITED1 contributes to the progression of papillary thyroid carcinoma via the Wnt/β-catenin signaling pathway</p>
... The animal experiment was approved by the Ethics Committee of the First Af fi liated Hospital of Chongqing Medical University. Fifteen female BALB/C nude mice (aged 4 – 6 weeks) were purchased from Beijing Huafukang ...
9
ART3 regulates triple-negative breast cancer cell function via activation of Akt and ERK pathways
... Triple-negative breast cancers (TNBCs) are defined by lack of expressions of estrogen, progesterone, and ERBB2 receptors. Because biology of TNBC is poorly understood, no targeted therapy has been developed for this ...
14
Erythropoietin is a JAK2 and ERK1/2 effector that can promote renal tumor cell proliferation under hypoxic conditions
... Recently, concerns have arisen over the potential of re- combinant human erythropoietin (rhEPO) treatment and an association with tumor growth [11,12]. The effect may be induced through interaction with tumor cell EPO ...
14
The Lineage Determining Factor GRHL2 Collaborates with FOXA1 to Establish a Targetable Pathway in Endocrine Therapy-Resistant Breast Cancer.
... TAMR tumors were established in tamoxifen-treated mice and then received further treatment with anti-LYPD3, anti-AGR2 or IgG control antibodies (15mg/kg, 2X weekly) or both anti-LYPD3 + anti-AGR2 ...in ...
38
Targeting endogenous DLK1 exerts antitumor effect on hepatocellular carcinoma through initiating cell differentiation
... of xenograft tumors derived from both Huh-7 and Hep3B stable cell lines with DLK1 knockdown was significantly inhibited as compared to that of control with luciferase knockdown (Figure ...
11
Inhibition of basal like breast cancer growth by FTY720 in combination with epidermal growth factor receptor kinase blockade
... TNBC xenograft tumors in nude mice, the drug combination inhibited tumor growth and prolonged mouse survival, although this effect was not significant for the gefitinib-resistant cell line ...TNBC ...
14
Current status and perspectives of patient-derived xenograft models in cancer research
... line xenograft model has been used for evaluation of microwave hyperthermia therapy [64]; however, PDX models have been rarely reported in the evaluation of microwave hyperthermia ...
14
Application of a patient-derived xenograft model in cytolytic viral activation therapy for nasopharyngeal carcinoma
... these tumors compared with in vitro-cultured NPC cell lines and a C666-1 xenograft showed that the gene profile of the PDX tumor was more similar to the clinical sample than the C666-1 xenograft and ...
12
Carbonic anhydrase 2 (CAII) supports tumor blood endothelial cell survival under lactic acidosis in the tumor microenvironment
... Current targets of tumor angiogenesis have not suc- cessfully eliminated cancer or effectively decreased angiogenesis due to various mechanisms of acquired resistance or side effects caused by nonspecific effects on NECs ...
15
Bufalin-loaded mPEG-PLGA-PLL-cRGD nanoparticles: preparation, cellular uptake, tissue distribution, and anticancer activity
... Results: BNPs were of uniform size with an average particle size of 164 ± 84 nm and zeta potential of 2.77 mV. The encapsulation efficiency was 81.7% ± 0.89%, and the drug load was 3.92% ± 0.16%. The results of in vitro ...
9
Photosensitizer and peptide-conjugated PAMAM dendrimer for targeted in vivo photodynamic therapy
... study, the inhibitory role of free Affibody in inhibiting gene expression by an Affibody-mediated formulation was also demonstrated. The effect of Affibody conjugation compared to free PS and (PS-dendrimer) DPN is more ...
14
Establishment of a large panel of patient-derived preclinical models of human renal cell carcinoma
... 174 tumors) ...102 tumors). In our study, we chose to xenograft all RCC tumors operated at the New Hospital Civil of Strasbourg, in order to have a panel of RCCPDX models covering all ...the ...
24
Tumor xenograft animal models for esophageal squamous cell carcinoma
... tumor xenograft model is an alternate ani- mal cancer model used for ESCC ...orthotopic tumors. The procedure of establishing ortho- topic tumors is more technically demanding when com- pared to ...
8
Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice
... irradiated tumors as they begin to regrow after irradiation, and that 3 different ways of abrogating this influx (inhibition of HIF-1 or SDF-1/CXCR4 or depletion of monocytes/ macrophages) prevent, or ...
13