Y-box binding protein 1 (YB-1)
Epidermal growth factor receptor (EGFR) is transcriptionally induced by the Y box binding protein 1 (YB 1) and can be inhibited with Iressa in basal like breast cancer, providing a potential target for therapy
... factor, Y-box binding protein-1 (YB-1), protein is commonly expressed in ER-nega- tive breast cancers [4], and loss of this receptor is one of the hallmarks of BLBC ...
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Original Article High expression of Y-box-binding protein 1 is associated with local recurrence and predicts poor outcome in patients with colorectal cancer
... CRC. Y-box-binding protein 1 (YB-1) has been identified as a multifunctional oncoprotein in various ...that YB-1 may promote malignant progression of CRC ...
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Original Article Y-box-binding protein-1 and E-cadherin are potential prognostic factors in human bladder carcinoma
... unclear. Y-Box-binding protein 1 (YB-1) is a transcrip- tion/translation regulatory factor that belongs to the cold-shock domain superfamily ...of YB-1 ...
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Luteolin is a novel p90 ribosomal S6 kinase (RSK) inhibitor that suppresses Notch4 signaling by blocking the activation of Y-box binding protein-1 (YB-1)
... phosphorylates Y-box binding protein-1 (YB-1), an oncogenic transcription/translation factor, highly expressed in TNBC (~70% of cases) and associated with poor prognosis, ...
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Serum Y Box Binding Protein 1 (YBX 1) and Interleukin 6 (IL 6) Are Associated with Metastasis in Breast Cancer Patients
... of Y-box binding protein 1 (YBX-1) and interleukin 6 (IL-6) in the sera of metastatic and non-metastatic breast cancer patients (BC), investigate their clinicopatholog- ical ...
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Y-box binding protein 1 enhances DNA topoisomerase 1 activity and sensitivity to camptothecin via direct interaction
... domains YB-1 comprises [4,30], the N-terminal domain (amino acid (aa) 1–50) is critical for transcriptional regulation [31], the central cold shock domain (CSD: aa 51–129) has been recently revealed ...
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Y-Box Binding Protein 1 Stabilizes Hepatitis C Virus NS5A via Phosphorylation-Mediated Interaction with NS5A To Regulate Viral Propagation
... that YB-1 associates with NS5A to sustain the NS5A level ...that YB-1 has been identified as the HCV 5= and 3=NTR-interacing protein (42, 75, 76), it is likely that YB-1 ...
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Aloe-emodin inhibits HER-2 expression through the downregulation of Y-box binding protein-1 in HER-2-overexpressing human breast cancer cells
... Cell culture materials were obtained from Invitrogen (Burlington, Ontario, Canada). The reagents 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT), propidium iodide (PI) and the PureLink™ HiPure Plasmid ...
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Y-Box-Binding Protein 1 Interacts with Hepatitis C Virus NS3/4A and Influences the Equilibrium between Viral RNA Replication and Infectious Particle Production
... Flag– YB-1 protein was expressed and efficiently immunoprecipi- ...of YB-1 in HCV repli- cation, HCV RNA was more abundant in cells that overexpressed Flag-YB-1 than in ...
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High expression of Y-box-binding protein 1 correlates with poor prognosis and early recurrence in patients with small invasive lung adenocarcinoma
... The influence of YBX1 expression and other clinical factors on the patients’ overall survival (OS) was evalu- ated. As shown in Figure 4 and Table 3, the Kaplan–Meier survival curves of all 75 patients demonstrated that ...
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GFP Fusion Proteins: A Solution or a Problem?
... The Y-box binding protein 1 (YB-1) is a pleiotropic protein involved in a widenumber of cellular processes and a substantial amount of knowledge on ...
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Kindlin-2 interacts with β-catenin and YB-1 to enhance EGFR transcription during glioma progression
... up-regulating Y-box binding protein-1 (YB-1) and β-catenin expression, Kindlin-2 formed a transcriptional complex with YB-1 and β-catenin that bound to the ...
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Stable expression of Y box protein 1 gene in early development of the abalone Haliotis diversicolor
... Abalone H. diversicolor is a major cultured shellfish in south coastal areas of China. Prior studies of our lab have sequenced seven non-normalized transcriptomes of H. diversicolor that covered whole early developmental ...
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Functional Interaction between JC Virus Late Regulatory Agnoprotein and Cellular Y-Box Binding Transcription Factor, YB-1
... the Y-box binding protein YB-1 (6, 21, 39, 40), NF-B, Sp-1, Tst-1, NF-1, and Pur␣ (2, 6, 10, 15, 33–36, 41, ...factor YB-1 has been shown to ...
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Transcriptional regulation of human polyomavirus JC: evidence for a functional interaction between RelA (p65) and the Y-box-binding protein, YB-1.
... optimal binding sites for various NF- k B/rel dimers (24) and the D ...potential binding sites for TATA-binding protein, C/EBP, SP1, SRF, GR, NF-IL6, and other identified partners for NF- k ...
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Physical and Functional Interaction between the Y-Box Binding Protein YB-1 and Human Polyomavirus JC Virus Large T Antigen
... The Y-box binding proteins are the most evolutionarily con- served nucleic acid binding proteins, representing a multigene family identified in a number of organisms ranging from bac- teria to ...
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Cold shock Y-box protein-1 proteolysis autoregulates its transcriptional activities
... of YB-1 target genes MMP-2 and collagen type I [11,37] were ...full-length YB-1 (Figure 6). Notably, co-expression of CTF and full- length YB-1 resulted in a loss of ...
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Thrombin activates a Y box–binding protein (DNA binding protein B) in endothelial cells
... the YB-1 protein resulted in its localization to the nucleus versus the full-length protein that remained principally in the cytoplasm ...fusion protein of GFP and truncated dbpB, it ...
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<p>Elevated nuclear YBX1 expression and the clinicopathological characteristics of patients with solid tumors: a meta-analysis</p>
... Y-box binding protein 1 (YBX1) is a multifunctional protein of the cold-shock superfamily which plays different roles in both nucleus and ...by binding to the ...
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Induction of Kaposi's Sarcoma-Associated Herpesvirus-Encoded Viral Interleukin-6 by X-Box Binding Protein 1
... IF. Dual immunofluorescence IF for ORF45 and vIL-6 was performed on FFPE slides of MCD lymph node biopsy specimens that were deparaf- finized and rehydrated in Histo-Clear (National Diagnostics, Atlanta, GA) and an ...
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