Z-IETD-fmk
A cell-permeable dominant-negative survivin protein induces apoptosis and sensitizes prostate cancer cells to TNF-α therapy
... TNF- a induces cell apoptosis through the activation of caspase-8 which leads to the subsequent activation of caspase-3 [32]. Down-regulation of survivin by siRNA does not induce the activation of caspase-8 in cancer ...
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Taurolidine cooperates with antineoplastic drugs in neuroblastoma cells
... Berlin, Germany) working solutions were prepared by dilution with PBS (Life Technologies, Darmstadt, Germany) to designated concentrations. Povidone (Polyvinylpyrrolidone, Sigma-Aldrich, Steinheim, Germany) had a ...
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Ethanol extract of paeonia suffruticosa Andrews (PSE) induced AGS human gastric cancer cell apoptosis via fas-dependent apoptosis and MDM2-p53 pathways
... RPMI 1640, FBS (fetal bovine serum), trypsin-EDTA, and Dulbecco’s phosphate-buffered saline (D-PBS) were pur- chased from Welgene (Daegu, Korea). The antibiotic- antimycotic used was purchased from Gibco (Grand Is- land, ...
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Inhibition of apoptosis induced by ischemia reperfusion prevents inflammation
... istic for apoptosis, as well as increased caspase-1– and cas- pase-3–like activities in kidneys after 2 hours of reperfu- sion. These findings are in line with various in vivo and in vitro reports showing that renal ...
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Influence of ultrasound and proteolytic enzyme inhibitors on muscle degradation, tenderness, and cooking loss of hens during aging
... The potential contribution of mechanical disruption by ultrasonics and endogenous proteolytic enzymes on the tenderi- sation of hen muscle were investigated. The importance of endogenous enzymes was evaluated using ...
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tr05 pdf
... and FMK make this integration ...whereas FMK processes must live forever. Second, FMK provides quick context switching for its processes, so interrupts typically wake up a service ...provide ...
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The parabolic implosion for f0(z) = z + z v+1 + φ(2v=Z)
... For each s, 5 such family there will be associated fundamental regions {Si', 8 and an associated gate 3}i, structure G' E Admissible and perhaps Fatou coordinates defined on the sets {SS[r] ...
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Modification to the draft Council decision adopting a programme of research and development in the field of science and technology from development (1982 1985) COM (82) 480 final, 27 July 1982
... t*1 "lw the Commission presented to the Council a draft decision adopt i ng a programrne of research and deve[opment in the f ietd of science and technology for deveLopment 1982-1985 doc[r] ...
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Univalence of normalized solutions of W″(z)+p(z)W(z)=0
... In regions III U IV Robertson’s Main Theorem applies and our Corollary B.. In region IV Robertson’s Main Theorem applies and our Corollary B applies.[r] ...
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Original Article Z-VRPR-FMK can inhibit the growth and invasiveness of diffuse large B-cell lymphoma by depressing NF-κB activation and MMP expression induced by MALT1
... into the left forelimbs of all nude mice. The tumor formation was observed at different times, and a tumor growth curve was plotted. After the successful modeling, the animals were divided into experimental and control ...
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Apoptosis in Caspase-inhibited Neurons
... inhibitor z-Val-Ala-DL-Asp- fluoromethylketone (zVAD-fmk), the calpain in- hibitors Ac-Leu-Leu-L-norleucinal (LLN-CHO) and Ac-Leu-Leu-L-methional (LLM-CHO), the cathepsin B inhibitor ...
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RIPK3 Regulates Microvascular Endothelial Cell Necroptosis and Cardiac Allograft Rejection
... necrosis following apoptosis 137 , PI labeling while augmenting cell death using zVAD- fmk, Nec-1 and RIPK3 -/- MVECs in conjunction with the release of the inflammatory marker HMGB1 i[r] ...
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R-roscovitine Reduces Lung Inflammation Induced by Lipoteichoic Acid and Streptococcus pneumoniae
... R-roscovitine is an inhibitor of CDK-1, -2, -5 and -7, as assessed with purified ki- nase assays (10,27). To test if R-roscovi- tine can reduce CDK activation in vitro, the phosphorylation state of CDK sub- strates in ...
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Uniqueness of meromorphic solutions of the difference equation \(R {1}(z)f(z+1)+R {2}(z)f(z)=R {3}(z)\)
... Throughout the whole paper, for a meromorphic function f (z), we use standard notations of the Nevanlinna theory (see, e.g., [2, 8, 14]) such as T(r, f ), m(r, f ), and N(r, f ) and define respectively the order of ...
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Caspase Activation and Specific Cleavage of Substrates after Coxsackievirus B3-Induced Cytopathic Effect in HeLa Cells
... FIG. 4. ZVAD-fmk inhibits caspase activation as well as cleavage of PARP and DFF following CVB3 infection or induction of apoptosis by treatment of HeLa cells with BPD-MA and light. (A) Cell lysate was incubated ...
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Evaluation of the antitumor effects of c Myc Max heterodimerization inhibitor 100258 F4 in ovarian cancer cells
... Pretreatment with Z-VAD-FMK resulted in total blocking of 10058-F4 induced caspase-3 activity and a significant decrease in the inhibition of 10058-F4-mediated proliferation in both cell[r] ...
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Supplementation of transport and freezing media with anti-apoptotic drugs improves ovarian cortex survival
... Cryopreservation was performed by slow freezing ac- cording to the technique first described by Gosden [30, 31]. Z-VAD-FMK (10 μM) or S1P (10 μM) was added to the cryopreservative medium. For thawing, ...
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Differentiation inducing factor 3 mediates its anti-leukemic effect through ROS-dependent DRP1-mediated mitochondrial fission and induction of caspase-independent cell death
... 6-dihydroxy-4-methoxyphenyl) hexan-1-one) belong to a family of morphogens required for stalk-cell differentiation in DD [23]. DIF-1 and DIF-3 exert potent anti-leukemic effects in several cancer cell lines, the latter ...
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Heterologous production and characterisation of a yeast peptide:N glycanase : a thesis presented in partial fulfillment of the requirements for the degree of Master of Science in Biochemistry at Massey University, New Zealand
... Figure 3.29 a active site of the mouse PNGase in complex with a tripeptide inhibitor carbobenzyloxy-Val-Ala-Asp-a-fluoromethylketone Z-VAD-fmk The cata lytic triad is shown in pink while[r] ...
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Ex Vivo and In Vivo Inhibition of Human Rhinovirus Replication by a New Pseudosubstrate of Viral 2A Protease
... the z-LVLQTM- fmk-mediated inhibition was specific since this peptide also im- paired virus replication compared to the unrelated control pep- tide z-FA-fmk at 48 h postinfection ...
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