[PDF] Top 20 A highlight on Sonic hedgehog pathway
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A highlight on Sonic hedgehog pathway
... other pathway inhibitors or chemotherapy ...Shh pathway in- hibitors in MB treatment may offer an adequate therapeutic ...Shh pathway is very important during devel- opment, the adverse effect of ... See full document
15
An in vivo comparative study of sonic, desert and Indian hedgehog reveals that hedgehog pathway activity regulates epidermal stem cell homeostasis
... In vitro biochemical evidence has shown that Shh, Dhh and Ihh have equal binding affinities for the Ptc1 receptor thereby suggesting that redundancy between hedgehog protein activity may exist (Carpenter et al., ... See full document
11
Sonic Hedgehog Pathway as the Prognostic Marker in Patients with Extensive Stage Small Cell Lung Cancer
... Purpose: Sonic hedgehog (Shh) signaling pathway is known to play a crucial role in carcinogenesis in various malignancies, in- cluding lung cancer regarding tumorigenesis, angiogenesis, and cellular ... See full document
7
Sonic hedgehog pathway activation is associated with cetuximab resistance and EPHB3 receptor induction in colorectal cancer
... We also found increased expression of GLI-1 after EGFR suppression in EGFR-dependent SW48 cells. GLI-1 is a molecular factor for metastasis and cancer cell growth in various cancers [51]. In the present study, we ... See full document
17
From fruitflies to mammals: mechanisms of signalling via the Sonic hedgehog pathway in lung development
... It is evident that the Shh/ptc/smo/gli pathway is important in early pattern formation in the lung (Fig. 2). Bmp4 and Fgf10, which are both implicated in mammalian lung development, seem not to be regulated by Shh ... See full document
6
High expression of Sonic Hedgehog signaling pathway genes indicates a risk of recurrence of breast carcinoma
... the Sonic Hedgehog (SHH) signaling pathway contributing to carcinogenesis of some organs has been reported in the ...SHH pathway contributes to the recurrence of breast ...for Sonic ... See full document
8
Sonic Hedgehog Signaling Pathway in Endothelial Progenitor Cell Biology for Vascular Medicine
... signaling pathway have revealed significantly improvement in several ischemic disease models such as AMI [15,43], myocardial ischemic- reperfusion[48, HLI [17,23,45,72], stroke [73], diabetic wound healing[44], ... See full document
16
The effects of sonic hedgehog signaling pathway components on non small cell lung cancer progression and clinical outcome
... well-known prognostic factors, Shh and Gli expression were found to be associated with survival, which suggests that Shh and Gli expression may have prognostic value in- dependent of TNM staging with respect to the ... See full document
10
Sonic hedgehog in vertebrate neural tube development
... Similarly, dynamic neural Shh-Gli activity underlies development of the thamalic complex, a region of the brain that processes and relays sensory and motor information to and from the cortex. The thalamic complex is ... See full document
11
Activation of the sonic hedgehog signaling pathway occurs in the CD133 positive cells of mouse liver cancer Hepa 1–6 cells
... Shh pathway is activated in these cells that harbor stem cell features, with an underexpression of Shh mRNA and an overexpression of Smoh ...signaling pathway may be a potential therapeutic strategy for ... See full document
9
PM2.5 promotes human bronchial smooth muscle cell migration via the sonic hedgehog signaling pathway
... Our data show that PM2.5 caused a dramatic, time- dependent increase in Shh protein expression. Similar effects were observed for Gli1 and Snail expression. In- triguingly, Shh pathway activity increased ... See full document
11
The Sonic hedgehog pathway independently controls the patterning, proliferation and survival of neuroepithelial cells by regulating Gli activity
... Shh pathway that can activate or repress transcription of specific target genes (reviewed by Jacob and Briscoe, ...signaling pathway in vivo in chick embryos, we provide evidence that Shh acts directly on ... See full document
12
Signal dynamics in Sonic hedgehog tissue patterning
... components of the Hh pathway (Lum et al., 2003), and modeling can be used to test their potential mechanisms of action. Other molecules can also be included, such as Ptc2, Megalin, and the You class of proteins, ... See full document
13
<p>Antidepressant, anti-inflammatory, and antioxidant effects of electroacupuncture through sonic hedgehog–signaling pathway in a rat model of poststroke depression</p>
... Shh-signaling pathway, 48 rats were allocated ran- domly into six groups (n=8 for each group): sham, PSD, EA + PSD, EA + PSD + cyclopamine (intraperitoneal adminis- trations of ... See full document
9
Glucocorticoids and neonatal brain injury: the hedgehog connection
... the sonic hedgehog (Shh) signaling pathway, a crucial regulator of brain devel- opment and neural stem/progenitor cells (see the related study beginning on page ... See full document
5
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... The Hedgehog (Hh) signaling pathway was first identified in the common fruit ...evolutionary pathway of signal trans- mission from the cell membrane to the ...signaling pathway plays an ... See full document
13
The Design, Synthesis, and Biological Evaluation of Steroid-Derived Inhibitors of the Sonic Hedgehog Signaling Pathway
... SHH pathway, any disruption of the pathway would result in the same ...SHH pathway and not simply the inhibition of the luciferase, a key component required for ... See full document
440
Cholesterol precursors and facial clefting
... malformations. Sonic hedgehog and cleft palate The discovery that cholesterol is necessary for the maturation of hedgehog proteins (12) provided insight into a developmen- tal pathway that is ... See full document
5
Inhibition of SHH pathway mechanisms by arsenic trioxide in pediatric medulloblastomas: a comprehensive literature review.
... ABSTRACT. Recent innovations in the genomic understanding of medulloblastomas have provided new ways to explore this highly invasive malignant brain cancer arising from the cerebellum. Among the four different ... See full document
15
From inflammation to gastric cancer – the importance of Hedgehog/GLI signaling in Helicobacter pylori-induced chronic inflammatory and neoplastic diseases
... signaling pathway in gastric homeostasis has been established in several recent stud- ies (for reviews see ...the hedgehog family member sonic hedgehog (SHH) is re- quired to shape the mucosal ... See full document
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