[PDF] Top 20 A radical approach to nitrogen heterocycles
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A radical approach to nitrogen heterocycles
... the nitrogen substituent was a methoxycarbonyl group It was assumed that the electronic nature of the nitrogen may affect the stereoselectivity although how this electronic effect influences the ... See full document
265
A Cu-Catalysed Radical Cross-Dehydrogenative Coupling Approach to Acridanes and Related Heterocycles
... one-pot approach to acridanes 16 based on the α- arylation of 1,3-dicarbonyl compounds with haloarenes 21 generating intermediates 15 in situ which would then undergo the oxidative coupling procedure (Scheme ... See full document
10
Oxime derivatives : versatile reagents for radical mediated syntheses of heterocycles
... with radical chemistry and the ability of radicals to perform intramolecular cyclisations, together with the virtues of MAOS make the combination of both an extremely useful tool for organic and medicinal ...no ... See full document
269
Copper (I) mediated radical cyclisation novel approaches to nitrogen heterocycles
... Tandem radical cyclisation reactions have been catalysed using copper I chlorideibipy.19 For example, reaction of trichloroamide 38 with this catalyst at 40°C gave the diastereomeric bic[r] ... See full document
347
Synthesis of nitrogen heterocycles via amidyl radical cyclisations
... hex-5-enyl radical cyclisations) leading to a lower energy difference between alternative transition ...amidyl radical geometry (the preferred conformation for secondary amides) places the N-R group ... See full document
257
New approaches to nitrogen heterocycles via radical cyclisations
... Whilst these reductive conditions have proven successful in many applications including the synthesis of a number of natural products 24–27 there are certain disadvantages that limit the usefulness of the process. The ... See full document
293
Synthesis of nitrogen containing heterocycles via radical cyclisation
... In the last decade, the samarium Barbier reaction has been developed into a valuable synthetic method. Discovered by Kagan in 1980, its mechanism is not fully understood as yet. Nevertheless, one thing is certain, ... See full document
278
Tetrahydroquinolines and Isoxazoles: Nitrogen heterocycles as potential antibacterial agents
... We report here the synthesis of 4 THQs4a-d and 4 isoxazoles7a-d. The THQs were prepared by imino Diels-Alder cycloaddition [8], between different substituted anilines 1 selected by their ability to donate electrons and ... See full document
6
Synthesis of some benzothiazolyl and imidazole derivatives and evaluation of antibacterial activities
... Therefore, in our search for biologically active nitrogen heterocycle, we here in, reporting the synthesis and biological activity of some newly synthesized benzothiazolyl and imidozolyl derivatives. The ... See full document
8
The syntheses and testing of some nitrogen heterocycles for interaction with benzodiazepine receptors
... CONTENTS Page Certificate of originality i Acknowledgements ii Nomenclature iii Summary iv CHAPTER I Introduction I-1 Pharmacology of benzodiazepinesand their receptors 1 I - 1.1 General[r] ... See full document
270
The Synthesis and Biological Examination of 5-Membered Nitrogen-Based Heterocycles.
... Within the last two decades there has been a large amount of research devoted to Gram negative bacteria, identifying quorum sensing circuits for over 25 species of bacteria. W[r] ... See full document
262
The crystal structures and Hirshfeld surface analysis of 6 (naphthalen 1 yl) 6a nitro 6,6a,6b,7,9,11a hexahydrospiro[chromeno[3′,4′:3,4]pyrrolo[1,2 c]thiazole 11,11′ indeno[1,2 b]quinoxaline] and 6′ (naphthalen 1 yl) 6a′ nitro 6′,6a′,6b′,7′,8′,9′,10′,12a′ octahydro 2H spiro[acenaphthylene 1,12′ chromeno[3,4 a]indolizin] 2 one
... Nitrogen-containing heterocycles and their derivatives are present in many large molecules suitable for photo-chemical, electrochemical and catalytic applications; moreover, some derivatives also possess ... See full document
22
Facile synthesis of fused nitrogen containing heterocycles as anticancer agents
... synthesis of pyrazolopyridopyrimidines were based on utilizing amino pyrazole or amino pyrimidine as starting materials with different catalysts[5,13]. Aiming to synthesize these important candidates with low cost ... See full document
18
Comparitive Study of Antiinflammataory, Analgesic and Antimicrobial Activity of Triazole Heterocycles Including Some Nitrogen Condensed and Bridged Heterocycles
... When the same type of triazoles was constructed from ibuprofen moiety substituted at 3 rd position having amino and mercapto groups at position 4 and 5 respectively furnished 3-[(4’-iso[r] ... See full document
6
An Efficient Synthesis of Ethyl {[3-(hydroxymethyl) quinolin-2-yl]thio}acetate
... sulfur–nitrogen heterocycles includes highly stable aromatic compounds, that display physicochemical properties with relevance in the design of new materials especially those relating to molecular ... See full document
5
Non bonding 1,5 S•••O interactions govern chemo and enantioselectivity in isothiourea catalyzed annulations of benzazoles
... To conclude, we have demonstrated the scope and limitations of the organocatalytic enantioselective functionalization of a range of benzazole nucleophiles using the isothiourea HyperBTM 1 and a,b-unsaturated ... See full document
9
Highly efficient synthesis of heterocycles via 5 endo radical cyclisation
... l3 , 22 Giese found that the rate of addition of nucleophilic radicals to alkenes increases with the electron withdrawing ability of substituents on the alkene partner and with the numbe[r] ... See full document
293
Methyl (4 formyl 2 methoxycarbonylpyrrol 1 yl)acetate
... nitrogen heterocycles widely used in medicinal chemistry as well as the pharmaceutical and chemical industries and was selected for crystal structure determination in order to elucidate the conformation of ... See full document
7
Synthesis and biological activity of nitrogen heterocycles from anthranilic acid derivative
... The product obtained was filtered off, washed with water, dried and purified by frictionally crystallization with proper solvent to give 6 and 7.. The reaction mixture was cooled and pou[r] ... See full document
8
SYNTHESIS AND BIOLOGICAL ACTIVITIES OF SOME NEW HETEROCYCLES CONTAINING NITROGEN AND SULPHUR
... Incorporation of oxygen, nitrogen, sulphur, or an atom of a related element into an organic ring structure in place of a carbon atom gives rise to a heterocyclic compound. Since the heterocyclic atom must form ... See full document
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