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18 results with keyword: 'aberrant signaling pathways in cell acute lymphoblastic leukemia'

Aberrant signaling pathways in t-cell acute lymphoblastic leukemia

Calcineurin complex isolated from T-cell acute lymphoblastic leukemia (T-ALL) cells identifies new signaling pathways including mTOR/AKT/S6K whose inhibition synergize with

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2021
Aberrant ERG expression associates with downregulation of miR‐4638‐5p and selected genomic alterations in a subset of diffuse large B‐cell lymphoma

ERG+, aberrant ERG expression; AML, acute myeloid leukemia; T-ALL, T lymphoblastic leukemia; B-ALL, B lymphoblastic leukemia; DLBCL, diffuse large B-cell lymphoma; TMA,

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2021
Aberrant signaling in T-cell acute lymphoblastic leukemia: biological and therapeutic implications

T-cell acute lymphoblastic leukemia (T-ALL) is a biologically heterogeneous disease with respect to phenotype, gene expression profile and activation of particular

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8
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2019
Prediction of outcomes by early treatment responses in childhood T-cell acute lymphoblastic leukemia: a retrospective study in China

ALL: Acute lymphoblastic leukemia; T-ALL: T-cell acute lymphoblastic leukemia; B-ALL: B-cell acute lymphoblastic leukemia; MRD: Minimal residual disease; PR: Prednisone response;

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11
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2020
Signaling Pathways as Therapeutic Targets in Pediatric B-cell Precursor Acute Lymphoblastic Leukemia

we also observed co-occurrence of JAK2 and KRAS lesions in non-Down syndrome BCP-ALL cells. More importantly, these JAK2 and KRAS mutations showed different outgrowth

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199
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2021
Protein kinase inhibitors for acute leukemia

ALL: Acute lymphoblastic leukemia; AML: Acute myelocytic leukemia; BCP- ALL: B-cell precursor acute lymphoblastic leukemia; BLK: B lymphocyte kinase; BTK: Bruton ’ s tyrosine

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7
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2020
Hypoxia promotes chemoresistance in acute lymphoblastic leukemia cell lines by modulating death signaling pathways

Cell density Cell proliferation Cell viability (%) MCL-1 protein expression Bcl-2 protein expression Bim protein expression Normoxa More important Equal Equal Weakly expressed

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2021
T cell receptor gamma and delta rearrangements in hematologic malignancies  Relationship to lymphoid differentiation

T cell receptor delta gene recombinatorial events were found in 91% of acute T cell lymphoblastic leukemia, 68% of non-T, non-B lymphoid precursor acute.. lymphoblastic leukemia

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12
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2020
Pediatric T-Cell Acute Lymphoblastic Leukemia

Precursor T-cell lymphoblastic leukemia; T-cell acute lymphoblastic leukemia; T-cell ALL; T-ALL; T-cell receptor; thymocyte; transcription factor.. Clinics

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2021
Molecular And Therapeutic Implications Of Notch1 Signaling In Pediatric T-Cell Acute Lymphoblastic Leukemia

Inhibition of NOTCH signaling by gamma secretase inhibitor engages the RB pathway and elicits cell cycle exit in T-cell acute lymphoblastic leukemia

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172
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2021
Mutational spectrum of adult T-ALL

subgroup with favorable outcome in adult T-cell acute lymphoblastic leukemia (T-ALL): a Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL)

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13
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2020
Improving nelarabine efficacy in T cell acute lymphoblastic leukemia by targeting aberrant PI3K/AKT/mTOR signaling pathway

Furthermore, the combination of nelarabine with ZSTK-474 was able to induce a decrease in the Bcl2 and Bcl-xL protein expression in all cell lines resistant to nelarabine alone,

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16
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2020
MYC as therapeutic target in leukemia and lymphoma

leukemia; pre T-LBL, precursor T-cell lymphoblastic leukemia/lymphoma; AML, acute myeloid leukemia; DLBCL, diffuse large B-cell lymphoma; ALL, acute lymphocytic leukemia; T-ALL,

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2020
Exploratory Study of Predicted Indirectly ReCognizable HLA Epitopes in Mismatched Hematopoietic Cell Transplantations

HSCT, hematopoietic stem-cell transplantation; Acute leukemia, acute myeloid leukemia (36%); acute lymphoblastic leukemia (24%); myelodysplastic syndrome (30%); other (10%);

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8
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2021
ZNF384-related fusion genes define a subgroup of childhood B-cell precursor acute lymphoblastic leukemia with a characteristic immunotype

Immunophenotypic characteristics of B-cell precursor acute lymphoblastic leukemia (BCP-ALL) patients with ZNF384 -related fusion genes.. (A) Typical histograms of CD19, CD10,

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12
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2021
Childhood pre B cell acute lymphoblastic leukemia with translocation t(1;19)(q21 1;p13 3) and two additional chromosomal aberrations involving chromosomes 1, 6, and 13: a case report

ACAs: Additional cytogenetic abnormalities; ALL: Acute lymphoblastic leukemia; aMCB: Array-proven high-resolution multicolor banding; B-ALL: B cell acute lymphoblastic leukemia;

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6
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2020
Single-cell analysis of tumors: Creating new value for molecular biomarker discovery of cancer stem cells and tumor-infiltrating immune cells.

ALL: Acute lymphoblastic leukemia; AML: Acute myeloid leukemia; ccRCC: Clear cell renal cell carcinoma; CML: Chronic myeloid leukemia; CNV: Copy number variant; CSC: Cancer stem

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13
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2021
ABSTRACT: The present paper deals with

In order to reconstruct their revolutionary history, Djebar “ […] appropriates matriarchal ways of seeing and speaking in Algeria that legitimize Algerian women’s

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10
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2022

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