[PDF] Top 20 Accumulation of Substrates of the Anaphase-Promoting Complex (APC) during Human Cytomegalovirus Infection Is Associated with the Phosphorylation of Cdh1 and the Dissociation and Relocalization of APC Subunits
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Accumulation of Substrates of the Anaphase-Promoting Complex (APC) during Human Cytomegalovirus Infection Is Associated with the Phosphorylation of Cdh1 and the Dissociation and Relocalization of APC Subunits
... upon human cytomegalovirus (HCMV) infection of human fibroblasts is associated with the inactivation of the anaphase-promoting complex (APC), a multisubunit ... See full document
9
Inactivation and Disassembly of the Anaphase-Promoting Complex during Human Cytomegalovirus Infection Is Associated with Degradation of the APC5 and APC4 Subunits and Does Not Require UL97-Mediated Phosphorylation of Cdh1
... APC dissociation during HCMV infection does not require UL97-mediated phosphorylation of ...The accumulation of the APC substrates in the ⌬ UL97 virus-infected ... See full document
12
Studies on the Contribution of Human Cytomegalovirus UL21a and UL97 to Viral Growth and Inactivation of the Anaphase-Promoting Complex/Cyclosome (APC/C) E3 Ubiquitin Ligase Reveal a Unique Cellular Mechanism for Downmodulation of the APC/C Subunits APC1, APC4, and APC5
... Human cytomegalovirus (HCMV) deregulates the cell cycle by several means, including inactivation of the anaphase-promoting complex/cyclosome (APC/C) E3 ubiquitin ...the ... See full document
12
Analysis of Human Cytomegalovirus-Encoded MicroRNA Activity during Infection
... after infection, the ⌬ UL114 mutant and WT viruses generated similar quantities of the IE protein IE72, but the ⌬ UL114 mutant continued to produce high levels of IE72 late in infection, which could explain ... See full document
10
Antagonistic Gcn5-Hda1 interactions revealed by mutations to the Anaphase Promoting Complex in yeast
... in APC function, as altered expression of APC regulators may underlie the observed growth phe- ...in APC activity, whereas Pds1, Bcy1 and Mad2 have a negative impact ... See full document
16
Human Cytomegalovirus Infection Induces Rapamycin-Insensitive Phosphorylation of Downstream Effectors of mTOR Kinase
... the phosphorylation of mTOR effectors during the course of HCMV infection in the presence and absence of ...to infection, infected the cells with highly purified viruses in serum-free medium ... See full document
10
Human Cytomegalovirus Infection Leads to Accumulation of Geminin and Inhibition of the Licensing of Cellular DNA Replication
... Human cytomegalovirus (HCMV), an ubiquitous betaher- pesvirus, is the leading viral cause of birth defects and poses a serious health threat to immunocompromised individuals ...HCMV infection ... See full document
8
Binding and Relocalization of PKR 1 by Murine Cytomegalovirus
... pm142 or pm143, we analyzed the precipitated proteins by immunoblot analyses using 216.. either a mixture of rabbit anti-m142 and anti-m143 antisera or with a mouse monoclona[r] ... See full document
43
A Functional Analysis Reveals Dependence on the Anaphase-Promoting Complex for Prolonged Life Span in Yeast
... suppress apc mutations in multiple organisms (Yama- pressing APC5, however, experienced a reduced life shita et ...the APC complex, as both elevated and reduced levels cally relevant factors were ... See full document
16
Nuclear pore protein NUP88 activates anaphase promoting complex to promote aneuploidy
... (MCCs) during interphase, much like they do when they are bound to unattached kinetochores in mitosis ...the anaphase-promoting complex/ cyclosome (APC/C) coactivator ...and ... See full document
18
Human Cytomegalovirus pUL47 Modulates Tegumentation and Capsid Accumulation at the Viral Assembly Complex
... pUL47/pUL48 complex formation (29, 40), we supposed that pUL47 would follow pUL48 distribution during ...the complex formation of pUL47 and ...very complex, with overlapping transcripts (90), ... See full document
15
Asymmetric localisation of Miranda and its cargo proteins during neuroblast division requires the anaphase promoting complex/cyclosome
... the anaphase-promoting complex/ cyclosome (APC/C), in regulating the basal localisation of ...The APC/C is a multi-subunit protein complex with at least 11 core subunits ... See full document
7
Binding and Nuclear Relocalization of Protein Kinase R by Human Cytomegalovirus TRS1
... the phosphorylation of eIF2 ␣ and the subsequent shutoff of protein synthesis that occur during infection of HeLa cells with VV ⌬ E3L, while a deletion mutant expressing amino acids 1 to 738 behaves ... See full document
11
The Anaphase Promoting Complex Regulates Yeast Lifespan and rDNA Stability by Targeting Fob1 for Degradation
... the APC also continues to ...that APC mutants result in loss of chromosomes and plasmids at accelerated rates (Hartwell and Smith 1985; Palmer et ...in APC mutants manifest as reduced lifespan in ... See full document
17
SUMO targets the APC/C to regulate transition from metaphase to anaphase
... equator during metaphase as well as the time that passed from metaphase until sister chromatid separation in anaphase for 200 mitotic cells per condition resulting from three independent experiments ... See full document
15
Intracellular Signaling by the Chemokine Receptor US28 during Human Cytomegalovirus Infection
... CMV infection of primary endothelial cells (HUVECs) was established with a clinical isolate of CMV, strain 4010, originally isolated from the urine of an AIDS patient and passaged only twice in ...Productive ... See full document
10
Biphasic regulation of A20 gene expression during human cytomegalovirus infection
... regulation during HCMV infection is not ...activity during infection in a timely ...HCMV infection may just reflect the increase of NF-κB activity upon virus infection and this ... See full document
9
HTLV 1 Tax mutants that do not induce G1arrest are disabled in activating the anaphase promoting complex
... unscheduled, APC-mediated deg- radation of Clb2p and Pds1p, G 2 /M delay, chromosome aneuploidy, growth arrest, and loss of cell viability ...dysregulates APC/C and mito- sis, which is otherwise difficult ... See full document
12
Contribution of CAF-I to Anaphase-Promoting-Complex-Mediated Mitotic Chromatin Assembly in Saccharomyces cerevisiae
... chromosomes during the segregation of sister chromatids or to establish a transcriptionally primed genome as cells exit ...cerevisiae APC is required for longevity ...the APC plays a pivotal role in ... See full document
12
The Anaphase Promoting Complex Contributes to the Degradation of the S. cerevisiae Telomerase Recruitment Subunit Est1p
... late anaphase/ telophase ...[43–45,59], APC Cdh1p is not active during the cdc15-2 ...that APC Cdc20p is active and able to mediate Pds1p proteolysis prior to the arrest ... See full document
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