1 9 6 5 ) . Whi le some s h r i nkage of nerve f i bres ha s been observed at the u l t r a s tructural leve l , a s a resul t of f i x a t i on and subsequent proce s s ing of nerve , i t ha s been conc luded that no appre c iable change in morphology occur s , a s a l l components of nerve f i bres are a f fected to a s im i lar degree ( Arbuthnot t e t a � 1 9 8 0 ) . The preservat ion of nerve f i bres in e l ectron m i cros copy is cons idered to be adequa te if no s pl i t t ing of the mye l i n s heath has occurred , apart f rom the Schmidt-Lantermann i n c i sure s , if the axo lemma adhere s c l o s e ly to the i nner turns of the mye l i n sheath , and i f the f i ne structure of mitochondria , neurof i l aments and mi crotubu l e s is pre served . Some spl i t t i ng of the mye l i n i s l ikely i n the large s t f ibres w i th the thick e s t mye l i n shea th s ( Arbuthnott e t aL , 1 9 8 0 ) . Unmy? l i na ted nerve f i bre s may be v i s ible on l i ght mi croscopy , but can on ly be examined in deta i l by e lectron m i croscopy . Observat ion of the f i ne s tructure of axona l organe l le s may prov ide informa t ion l i nk i ng s t ructural changes of the various s ubce l lu l a r components w i th unde r l y i ng bi ochemi ca l d i s turbance s , a s we l l a s provid ing an extreme ly sen s i t ive method of detect ing minima l patho log i c a l change ( Dayan , 1 9 7 9 ) . Aga in , care mu s t be taken not to m i s take damage induced by inadequate care in the co l l ect i on a nd proc e s s ing of t he nerve , for true pa t holog i ca l change s .
This thesis examined the bacterial biotransformation of glucosinolates by two lactic acid bacteria and Escherichia coli Nissle 1917, all three considered beneficial bacteria. They were compared with a known glucosinolate-metabolising gut bacterium Enterobacter cloacae in vitro, in vivo and ex vivo to determine the bacterial responses to glucosinolates and what the products of their glucosinolate metabolism might be. Exposure of the host to beneficial bacteria and glucosinolates resulted in induction of the host detoxification enzyme quinone reductase which was elevated in bladder tissue for all dietary intervention groups consuming glucosinolates and beneficial bacteria, alone or combined.
Ang l icans continued to fo l l ow British d e v e l opments c l os e l y. The Church Gazette , for instance , reported eminent Br itish sci entist Dr Carpenter 's 1 87 3 assertion that evo lution presented 'a far grand e r notion o f Creat i v e Des ign , than the idea of specia l interpositions required to remed y the irregu l ar working o f a machine irregu l ar l y constructed in the first instance1•22 High Churchman Canon H.P. Liddon was reported in the same year as asserting that e v o l ut ion ' from a Theistic point o f v iew, i s mer e l y our way o f describing what we c an observe of God ' s cont inuous action upon the physical wor l d 1 •23 By the end of the decade Canon Curteis articu l ated the Br itish trend whi ch co loni a l Ang l i cans undoubted l y fo l l owed : 'To a l arge and increasing number of Churchmen the e v o l ution hypothes i s appears , not on l y