[PDF] Top 20 Activation of hypothalamic S6 kinase mediates diet induced hepatic insulin resistance in rats
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Activation of hypothalamic S6 kinase mediates diet induced hepatic insulin resistance in rats
... Prolonged activation of p70 S6 kinase (S6K) by insulin and nutrients leads to inhibition of insulin signaling via negative feedback input to the signaling factor ...against ... See full document
11
Acute Hepatic Insulin Resistance Contributes to Hyperglycemia in Rats Following Myocardial Infarction
... of insulin on phospho- rylation of Akt within MI rats was mark- edly lower than that within controls, though insulin-stimulated phosphoryla- tion of Akt was comparable between MI and control ...of ... See full document
9
Two defects contribute to hypothalamic leptin resistance in mice with diet induced obesity
... leptin- induced STAT3 activation is undetectable after ip lep- tin, but is present after icv leptin administration, after 15 weeks of high-fat ...of rats with DIO was increased ... See full document
7
Spexin alleviates insulin resistance and inhibits hepatic gluconeogenesis via the FoxO1/PGC-1α pathway in high-fat-diet-induced rats and insulin resistant cells
... Insulin resistance is a multifaceted disorder that involves the modulation of various genes at the transcriptional and translational ...transcriptional activation of PGC-1α, which serve as essential ... See full document
15
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... known insulin sensitizers selected for the present ...that insulin sensitizers may help to reduce the occurrence of AS and HS associated with ...GCs induced AS and HS in Wistar ... See full document
5
Palmitic acid mediates hypothalamic insulin resistance by altering PKC θ subcellular localization in rodents
... on hypothalamic insulin activity in rats and ...impaired hypothalamic insulin and leptin ...nor induced insulin ...ated diet-induced obesity and improved ... See full document
14
Exercise training performed simultaneously to a high-fat diet reduces the degree of insulin resistance and improves adipoR1-2/APPL1 protein levels in mice
... Increased activation of the IKK/NF-κB pathway results in increased serine 307 phosphorylation of IRS-1 that, ultimately, leads to impaired insulin signaling in several peripheral tissue ...that ... See full document
9
Hypothalamic resistin induces hepatic insulin resistance
... in insulin-sensi- tive organs ...and insulin, exert some of their gluco-regulatory actions through the activation of hypothalamic ...in hypothalamic resistin per se could regulate ... See full document
10
KBH 1, an herbal composition, improves hepatic steatosis and leptin resistance in high fat diet induced obese rats
... leptin resistance as the pathological status in clinics ...a diet-induced animal model is invariably accom- panied by hyperleptinemia, and long-lasting hyperleptine- mia causes the failure of ... See full document
12
Original Article High-fat diet induced insulin resistance in pregnant rats through pancreatic pax6 signaling pathway
... pregnant rats after consumption of high-fat diet and the underlying ...Wistar rats were randomly divided into two groups: high-fat diet group and normal control ...serum insulin ... See full document
7
HYPOGLYCEMIC EFFECT OF 2 HYDROXYCHALCONE ON HIGH FRUCTOSE FED DIABETIC RAT
... enough insulin or alternatively when the body cannot effectively use the insulin it produces hyperglycemia or raised blood sugar, is a common effect of uncontrolled diabetes and overtime leads to serious ... See full document
5
Molecular responses to abiotic stress and the development of drought tolerance in plants
... A gene encoding a mitogenactivated protein kinase kinase kinase is induced simultaneously with genes for a mitogen-activated protein kinase and an S6 ribosomal protein kinase by touch, c[r] ... See full document
494
Reversal of diet induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl CoA carboxylases 1 and 2
... RT-PCR. Hepatic Acc1 (265 kDA) and Acc2 (280 kDa) protein levels were assessed by Western blot analysis ...from rats in the fed state ...4–6 rats per treatment ... See full document
9
Activation of the IGF1R pathway potentially mediates acquired resistance to mutant-selective 3rd-generation EGF receptor tyrosine kinase inhibitors in advanced non-small cell lung cancer
... novo resistance to ...[24], activation of the IGF1R pathway with IGFBP3 loss was suggested to be involved in resistance to irreversible EGFR-TKIs such as WZ4002 or ... See full document
11
Activation of skeletal muscle casein kinase II by insulin is not diminished in subjects with insulin resistance
... five insulin-resistant diabetic Pima Indians during a 2 h hyperinsulinemic, euglycemic ...plasma insulin concentrations, suggesting that the higher activity in resistant subjects resulted from ... See full document
7
Abnormal regulation of ribosomal protein S6 kinase by insulin in skeletal muscle of insulin resistant humans
... for insulin resistance, we investigated the influence of insulin on ribosomal protein S6 kinase activities in skeletal muscle of insulin-sensitive and insulin- resistant ... See full document
6
Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidation
... Effect of CPT-I inhibition, UCP-1, and MnSOD on FFA-induced ROS production. Cells were incubated in 5 mM glucose alone or in 5 mM glucose plus either oleic acid alone or oleic acid plus either tetradecyl- ... See full document
11
Association of moderately elevated trimethylamine N-oxide with cardiovascular risk: is TMAO serving as a marker for hepatic insulin resistance
... upregulate hepatic expression and activity of FMO3, chiefly responsible for conversion of TMA to TMAO, therefore, fall under ...subnormal hepatic insulin activity reflecting hepatic ... See full document
8
Critical role of stearoyl CoA desaturase–1 (SCD1) in the onset of diet induced hepatic insulin resistance
... enhanced insulin action to an extent that restored insulin sensitivity to normal lev- els in insulin-resistant ...Enhanced insulin signaling could account for these ...the hepatic phos- ... See full document
11
Insulin receptor Thr1160 phosphorylation mediates lipid induced hepatic insulin resistance
... to hepatic insulin resistance involves diacylglycerol-mediated (DAG-mediated) activation of protein kinase C-e (PKCe) and the consequent inhibition of insulin receptor (INSR) ... See full document
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