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[PDF] Top 20 Adipocyte JAK2 mediates growth hormone–induced hepatic insulin resistance

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Adipocyte JAK2 mediates growth hormone–induced hepatic insulin resistance

Adipocyte JAK2 mediates growth hormone–induced hepatic insulin resistance

... induces hepatic insulin resistance, which is dependent on adipocyte ...that insulin sensitivity is augmented in the setting of loss-of-function JAK2A mutants, we next determined the ... See full document

15

Adipocyte JAK2 mediates spontaneous metabolic liver disease and hepatocellular carcinoma

Adipocyte JAK2 mediates spontaneous metabolic liver disease and hepatocellular carcinoma

... GH resistance promotes age-associated IR via adipocyte ...of hepatic GH resistance through hepatocyte-specific deletion of Jak2 in JAK2L and JAK2LA mice essentially eliminated ... See full document

16

Regulation of growth hormone induced JAK2 and mTOR signalling by hepatic protein tyrosine phosphatase 1B.

Regulation of growth hormone induced JAK2 and mTOR signalling by hepatic protein tyrosine phosphatase 1B.

... including insulin, leptin, IGF-1 and growth hormone (GH) ...on JAK2, which is how PTP1B is thought to modulate GH signalling in the liver, based on studies utilising global PTP1B knockout mice ... See full document

14

Osteopontin mediates obesity induced adipose tissue macrophage infiltration and insulin resistance in mice

Osteopontin mediates obesity induced adipose tissue macrophage infiltration and insulin resistance in mice

... of insulin resistance during ...improved insulin sensitivity in the absence of an effect on diet-induced obesity, body composition, or ... See full document

13

CELLULAR GROWTH, NUTRITION AND DEVELOPMENT

CELLULAR GROWTH, NUTRITION AND DEVELOPMENT

... insulin growth hormone, and einephrine on cell growth in liver, muscle, and brain of. the hypophysectomised rat[r] ... See full document

22

No Dose Response Relationship in the Effects of Commonly Consumed Sugars on Risk Factors for Diabetes across a Range of Typical Human Consumption Levels

No Dose Response Relationship in the Effects of Commonly Consumed Sugars on Risk Factors for Diabetes across a Range of Typical Human Consumption Levels

... fructose-induced insulin resistance has been previously shown in ...weight. Insulin resistance was measured using the Homeostasis Model Assessment (HOMA IR) on fasting measures and a ... See full document

12

<p>Effect of Insulin-Regulated FOXC2 Expression in Adipocyte Differentiation and Insulin Resistance</p>

<p>Effect of Insulin-Regulated FOXC2 Expression in Adipocyte Differentiation and Insulin Resistance</p>

... in adipocyte has a regulating effect on the insulin signaling pathway and changes the insulin-mediated glucose homeostasis and fat metabolism ...and insulin signal transduction ... See full document

9

Macrophage migration inhibitory factor deficiency ameliorates high fat diet induced insulin resistance in mice with reduced adipose inflammation and hepatic steatosis

Macrophage migration inhibitory factor deficiency ameliorates high fat diet induced insulin resistance in mice with reduced adipose inflammation and hepatic steatosis

... Obese MIF 2/2 SVF secreted less TNFa and IL-1b compared to WT SVF. IL-10 secretion was increased from MIF 2/2 SVF compared to WT SVF. In contrast lack of MIF did not alter adipose T-cell CD8 + or CD4 + populations as ... See full document

14

The Role of Insulin-Like Growth Factor 2 and Its Receptors in Human Tumors

The Role of Insulin-Like Growth Factor 2 and Its Receptors in Human Tumors

... suppressed growth of mammary ...secreted insulin-like sub- stance stimulated glucose uptake by rat epididymal adipose cells and competed with radiolabeled in- sulin for binding to these ...of growth ... See full document

10

Role of receptor for advanced glycation end products (RAGE) in liver disease

Role of receptor for advanced glycation end products (RAGE) in liver disease

... higher hepatic levels of AGEs and RAGE compared with nor- mal mice ...(G/L)- induced liver injury was enhanced in UCP2 knockout mice, which was associated with increased AGEs and RAGE levels in the liver ... See full document

7

Two novel LHX3 mutations in patients with combined pituitary hormone deficiency including cervical rigidity and sensorineural hearing loss

Two novel LHX3 mutations in patients with combined pituitary hormone deficiency including cervical rigidity and sensorineural hearing loss

... BMP4), fibroblast growth factor (FGF8, 10 and 18), Sonic Hedgehog (SHH) and wingless (WNT4) pathways [21]. Within the developing Rathke’s pouch and anterior pituitary, a number of transcription factors are ... See full document

10

An insulin induced DNA binding protein for the human growth hormone gene

An insulin induced DNA binding protein for the human growth hormone gene

... As insulin regulates transcription of the growth hormone (GH) gene, we tested nuclear extracts from unstimulated and insulin-stimulated Chinese hamster ovarian (CHO) cells for binding to four ... See full document

7

PKCλ in liver mediates insulin induced SREBP 1c expression and determines both hepatic lipid content and overall insulin sensitivity

PKCλ in liver mediates insulin induced SREBP 1c expression and determines both hepatic lipid content and overall insulin sensitivity

... plasma insulin concentrations were determined as described ...and insulin toler- ance tests, mice deprived of food for 16 hours were injected intraperitoneally with glucose (2 g/kg body mass); mice in the ... See full document

11

Assessment of Thyroid Function Parameters among Sudanese Pregnant Women in Different Trimesters

Assessment of Thyroid Function Parameters among Sudanese Pregnant Women in Different Trimesters

... Across pregnancy trimester our study illustrated significant decrease of FT3 level in the three trimester, and FT4 is significantly decreased in the second and third trimester, where as TSH is slightly fluctuation in the ... See full document

8

Calorie restriction and cancer prevention: a mechanistic perspective

Calorie restriction and cancer prevention: a mechanistic perspective

... or growth in multiple experimental models, in- cluding colon, mammary, and hematopoietic cancer models ...sulfonylurea, insulin, or other therapies ... See full document

11

Type A insulin resistance syndrome misdiagnosed as polycystic ovary syndrome: a case report

Type A insulin resistance syndrome misdiagnosed as polycystic ovary syndrome: a case report

... of insulin and testosterone were elevated, and gynecological color Doppler ultrasound suggested multiple cystic changes in the bilateral ...gonadotropin-releasing hormone therapy and metformin were ... See full document

6

GROWTH HORMONE LEVELS DURING SLEEP IN NORMAL AND GROWTH HORMONE DEFICIENT CHILDREN

GROWTH HORMONE LEVELS DURING SLEEP IN NORMAL AND GROWTH HORMONE DEFICIENT CHILDREN

... Growth hormone responses in a normal child ( Subject 2 ) to insulin- induced hypoglycemia and sleep. In sleep study A, the duration of slow wave.. sleep was brief, resulting in impaired [r] ... See full document

11

Insulin like growth factor I mediates selective anabolic effects of parathyroid hormone in bone cultures

Insulin like growth factor I mediates selective anabolic effects of parathyroid hormone in bone cultures

... the hormone was ...increased insulin-like growth factor (IGF) I concentrations by two to fourfold, and an IGF I antibody prevented the PTH stimulation of collagen synthesis, but not its mitogenic ... See full document

7

Adult Height, Insulin Levels and 17β-Estradiol in Young Women

Adult Height, Insulin Levels and 17β-Estradiol in Young Women

... To our knowledge little is known about the relationship between adult height, adult body composition, serum insulin levels and 17β-estradiol throughout an entire menstrual cycle. However, epidemiological evidence ... See full document

17

Assessment of insulin action and glucose effectiveness in diabetic and nondiabetic humans

Assessment of insulin action and glucose effectiveness in diabetic and nondiabetic humans

... of hepatic and extrahepatic insulin resistance is comparable and whether the ability of glucose to regulate its own uptake and release is defective in non-insulin-dependent diabetes mellitus ... See full document

9

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