Top PDF {4 All­yl­oxy 2,6 bis­­[(di­methyl­amino)meth­yl]phenyl κ3C1,N,N′}iodido­palladium(II)

{2,6 Bis[(4R) 4 eth­oxy­oxazolin 2 yl]pyridine}di­chloro­manganese(II)

{2,6 Bis[(4R) 4 eth­oxy­oxazolin 2 yl]pyridine}di­chloro­manganese(II)

from the chiral ligand (R,R)-et-pybox {(R,R)-et-pybox is 2,6- bis[(4R)-4-ethoxyoxazolin-2-yl]pyridine}. The complex is mononuclear and its Mn atom has a distorted trigonal– bipyramidal coordination environment. In the complex, (R,R)-et-pybox is coordinated in a tridentate fashion to the Mn atom via three N atoms, having a pybox–cation ratio of 1:1.

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2 [2,6 Bis(pyrazin 2 yl)pyridin 4 yl]benzoic acid

2 [2,6 Bis(pyrazin 2 yl)pyridin 4 yl]benzoic acid

aromatic – stacking interactions [centroid–centroid distances = 3.9186 (4) and 3.9794 (5) A ˚ ] occur between the antiparallel molecules, generating infinite chains along [100]. O—H O hydrogen bonds connect the chains, leading to the formation of a two-dimensional supramolecular network parallel to (010). Intermolecular C—H N hydrogen bonds are also observed.

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Fabrication and Characterization of Unsaturated Copolyesters Based on Diarylidenecyclohexanone

Fabrication and Characterization of Unsaturated Copolyesters Based on Diarylidenecyclohexanone

Abstract: New series of unsaturated copolyesters based on diarylidenecyclohexanone, were synthesized by the interfacial polycondensation polymerization technique. Aldol condensation reaction in acid media was used for preparation of three kinds of monomers and investigated by FT IR and 1 H NMR. The copolymers have been synthetized by the polymerization of 2, 6-bis (4-hydrxybenzylidene) cyclohexanone I, 2, 6-bis (3-hydroxybezylidene) cyclohexanone II, or 2, 6-bis (4-hydroxy-3- methoxybenzylidene) cyclohexanone III with isophthaloyl, terphthaloyl, adipoyl, sebacoyl and azobenzene 4, 4- dicaroxyldichloride. The resulting copolyesters were characterized by FT-IR, 1 HNMR. The intrinsic viscosity of these copolyesters was used for the determination of the molecular weight. The thermal stabilities of the prepared copolyesters were evaluated thermogravimeteric analysis (TGA). Differential thermal analysis (DTA) was used for determination of glass temperatures. X–ray analysis showed that polymers have low degree of crystallinity. The morphological properties of some selected copolyesters were detected by SEM. The dielectric and electrical resistance, capacitance, inductance, demonstrating the insulator behaviour of copolymers.
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Ethyl 2 [(2 oxo 2H chromen 7 yl)­­oxy]acetate

Ethyl 2 [(2 oxo 2H chromen 7 yl)­­oxy]acetate

To a stirred solution of 7-hydroxycoumarin (500 mg, 3 mmol) in dry acetone, potassium carbonate (900 mg, 6 mmol) was added. After stirring for five minutes, ethyl chloroacetate (564 mg, 4.6 mmol) and a catalytic amount of TBAB were added to it. The whole reaction mixture was further stirred for 12 h at room temperature. After evaporation, water was added to it and the reaction mixture was extracted with chloroform thrice. The organic solvents were combined together and dried over anhydrous sodium sulphate and evaporated under reduced pressure. The crude product was purified through column chromatography (silica gel, 100-200 mesh size) using 15% ethyl acetate in petroleum ether as eluent to afford a pure colourless crystalline solid. Yield: 98%. M. p. 74-76 °C.
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1,4 Bis{[5 (pyridin 4 yl) 1,3,4 oxa­diazol 2 yl]sulfan­yl}butane

1,4 Bis{[5 (pyridin 4 yl) 1,3,4 oxa­diazol 2 yl]sulfan­yl}butane

A suspension of 5-(pyridin-4-yl)-1,3,4-oxadiazole-2-thiol (2.0 mmol) and 1,1-dibromobutane (1.0 mmol) in ethanol (10 mL) was stirred at room temperature. The reaction progress was monitored via TLC. The resulting precipitate was filtered off, washed with cold ethanol, dried and purified to give the target product as light-yellow solid in 87% yield. Crystals of (I) suitable for single-crystal X-ray analysis were grown by slow evaporation of a solution in chloroform- ethanol (1:1).

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2 (6 Meth­­oxy­naphthalen 2 yl) 1 (morpholin 4 yl)propan 1 one

2 (6 Meth­­oxy­naphthalen 2 yl) 1 (morpholin 4 yl)propan 1 one

O1 0.0555 (18) 0.053 (2) 0.073 (2) 0.0001 (15) 0.0157 (16) −0.0012 (16) O2 0.052 (2) 0.039 (2) 0.158 (4) 0.0020 (15) 0.009 (2) 0.000 (2) O3 0.062 (2) 0.056 (2) 0.147 (3) 0.0147 (17) 0.002 (2) 0.007 (2) N1 0.044 (2) 0.037 (2) 0.102 (3) 0.0007 (17) 0.007 (2) −0.0035 (19) C1 0.036 (2) 0.050 (3) 0.053 (3) 0.000 (2) −0.004 (2) −0.003 (2) C2 0.040 (2) 0.037 (2) 0.060 (3) −0.0007 (19) −0.010 (2) 0.003 (2) C3 0.037 (2) 0.042 (2) 0.048 (3) 0.0008 (19) −0.0062 (19) 0.0000 (19) C4 0.036 (2) 0.046 (3) 0.048 (3) −0.0011 (18) −0.007 (2) 0.004 (2) C5 0.048 (2) 0.038 (2) 0.068 (3) 0.0066 (19) 0.003 (2) 0.008 (2)
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Synthesis of aryl {4 [({5 [3 (methylsulfonyl)phenyl]pyrazin 2 yl} oxy)methyl]piperidin 1 yl}methanones

Synthesis of aryl {4 [({5 [3 (methylsulfonyl)phenyl]pyrazin 2 yl} oxy)methyl]piperidin 1 yl}methanones

Pyrazine nucleus potent biological activities with remarkable pharmaceutical importance and some of their derivatives occur as natural products. In view of these findings, it made interest to synthesize 2-(piperidin-4- ylmethoxy) pyrazines derivatives by the condensation of 2-[3-(methylsulfonyl) phenyl]-5-(piperidin-4-ylmethoxy) pyrazine with various aromatic acid chlorides in the presence of diisopropyl amine (DIPA).

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Bis{4 chloro 6 formyl 2 [(E) 2 (1H imidazol 4 yl κN3)ethyl­imino­methyl κN]phenolato κO1}nickel(II)

Bis{4 chloro 6 formyl 2 [(E) 2 (1H imidazol 4 yl κN3)ethyl­imino­methyl κN]phenolato κO1}nickel(II)

Geometry . All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes.

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Safety data sheet. Revision: Replaces: Version: 04.00/GBR

Safety data sheet. Revision: Replaces: Version: 04.00/GBR

May cause slight irritation to the skin and eyes. Degreases and dries the skin. Repeated exposure may cause skin dryness or cracking. Persons with a known allergy to Reaction products of bis(4-methylpentan-2-yl)dithiophosphoric acid with phosphorus oxide, propylene oxide and amines, C12-14-alkyl (branched) may exhibit an allergic response to the product.

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Ethyl 6 (6 meth­­oxy­naphthalen 2 yl) 4 (naphthalen 2 yl) 2 oxo­cyclo­hex 3 ene 1 carboxyl­ate

Ethyl 6 (6 meth­­oxy­naphthalen 2 yl) 4 (naphthalen 2 yl) 2 oxo­cyclo­hex 3 ene 1 carboxyl­ate

Chalcones and their corresponding heterocyclic analogs are valuable intermediates in organic synthesis (Dhar, 1981). This scaffold is found in various medicinally useful compounds and is known to exhibit a multitude of biological activities (Dimmock et al. , 1999). The crystal structures of (±)-ethyl 6-(6-methoxy-2-naphthyl)-4- (4-methylphenyl)-2- oxocyclohex-3-ene-1-carboxylate (Li et al. , 2009) and ethyl 4-(2,4-dichlorophenyl)-6-(6-methoxy-2- naphthyl)-2-oxo- cyclohex-3-ene-1-carboxylate (Harrison et al. , 2010) have been reported. Recently, we have reported the crystal and molecular structure studies of ethyl 4-(4-hydroxyphenyl)-6-(6-methoxy- 2-naphthyl)-2-oxocyclohex-3-ene-1-carboxylate and ethyl 4-(3- bromophenyl)-6-(6-methoxy-2-naphthyl)-2-oxocyclohex-3-ene-1-carboxylate (Manpreet Kaur et al. , 2012). As a part of our ongoing structural studies of substituted cyclohexene carboxylates, this paper reports the crystal structure of the title compound, (I), C 30 H 26 O 4 .
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Bis[4 (2 methyl 2 propen­yl)piperazin 1 yl]methane

Bis[4 (2 methyl 2 propen­yl)piperazin 1 yl]methane

The title compound, (I), was formed from 1-(2-methyl-2- propenyl)piperazine, which was easily prepared from the mono-Boc-protected piperazine (Boschi et al., 1994) and allylation of the second amine function with methallyl chloride and deprotection. 1-(2-Methyl-2-propenyl)piperazine is known and commercially available (CAS registry number: 57184–27-7) and was first synthesized by the Schering Corporation (Bloomfield & Sherlock, 1956) and later by Gao et al. (2003) by other methods.

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Synthesis and characterization of polyimides containing thiazole moiety

Synthesis and characterization of polyimides containing thiazole moiety

Polyimide (PI) having a favourable combination of properties such as high glass transition temperature (Tg), excellent mechanical properties, and good dimensional stabilities have been extensively investigated with both academic and industrial viewpoints. They have been widely employed in the aerospace, microelectronics, optoelectronics, composites and so on, because of their excellent balance of thermal and mechanical properties [1]-[2]. Incorporating heterocyclic unit into Polyimide main chain by using heteroaromatic monomers is also effective to improve thermal and mechanical properties of polyimides, saving the complex procedure of mechanical stretching. Here in this experiment a diamine monomer N,N’-Bis-[4-(2- amino-thiazol-4-yl)-phenyl] isophthalamide [ATPIPA] (II) was prepared through two step synthesis [1]-[3]. N,N’-Bis-(4-acetyl phenyl) isophthalamide (I) was prepared firstly by refluxing p-aminoacetophenone in dry DMAC with isopthalyol chloride in presence of nitrogen atmosphere, few crystals of LiCl were added. The N, N’-Bis-[4-(2-amino-thiazol-4-yl)-phenyl]
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2 {2 [4 (4 Fluoro­phen­yl)piperazin 1 yl] 2 oxoeth­yl} 6 (morpholin 4 yl) 4 phenyl­pyridazin 3(2H) one

2 {2 [4 (4 Fluoro­phen­yl)piperazin 1 yl] 2 oxoeth­yl} 6 (morpholin 4 yl) 4 phenyl­pyridazin 3(2H) one

For the pharmacological effects, biological activity and synthesis of 3(2H)-pyridazinones, see: S¸u¨ku¨rog˘lu et al. 2006; Brogden 1986. For bond-length data, see: Allen et al. (1987). For ring conformational analysis, see: Cremer & Pople (1975). For the quantum mechanical CNDO/2 approximation, see: Pople & Beveridge (1970).

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Crystal structure of hexa­prop 2 en 1 yl 4,4′,4′′,4′′′,4′′′′,4′′′′′ [1,3,5,2λ5,4λ5,6λ5 tri­aza­triphosphinine 2,2,4,4,6,6 hexa­yl­hexa­kis­(­­oxy)]hexa­benzoate

Crystal structure of hexa­prop 2 en 1 yl 4,4′,4′′,4′′′,4′′′′,4′′′′′ [1,3,5,2λ5,4λ5,6λ5 tri­aza­triphosphinine 2,2,4,4,6,6 hexa­yl­hexa­kis­(­­oxy)]hexa­benzoate

A mixture of hexachlorocyclotriphosphazene (1.04 g, 3 mmol), allyl 4-hydroxybenzoate (3.75 g, 21 mmol), and activated potassium carbonate (3.5 g, 253 mmol) in tetrahydrofuran (50 ml) was stirred at 66 °C for 45 h under nitrogen. The resulting suspension mixture was filtered and the filtrate was concentrated, leading to the formation of a faint yellow viscous liquid. It was dissolve in 20 ml ethyl acetate, and the solution was added dropwise to methanol. Colourless needle crystals suitable for X-ray diffraction analysis were obtained by slow evaporation of the solvent after about 2 days. S3. Refinement
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Di­ethyl [4 (2,2′:6′,2′′ terpyridine 4′ yl)phen­yl]phospho­nate

Di­ethyl [4 (2,2′:6′,2′′ terpyridine 4′ yl)phen­yl]phospho­nate

The title compound was prepared as a precursor for our study of molecular aluminophosphate building blocks possessing metal-coordinating groups. The molecule presents the usual conformation of nitrogen atoms in the two pyridine rings as nearly antiperiplanar oriented to that of the central ring of the terpyridine moiety (Fig. 1). The P=O bond adopts an essentially syn conformation with the plane of the attached ring. The torsion angle O3–P1–C44–C43 is 6.93 (14)°. Thus, the ethyl groups are conveniently located below and above the plane of the ring. All four aromatic rings are planar, with r.m.s. deviations not exceeding 0.0066 Å.
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Crystal structure of (E) 1 {2 [(5,5 di­methyl 1,3,2 dioxaphosphinan 2 yl)­­oxy]naphthalen 1 yl} N (4 fluoro­phen­yl)methanimine

Crystal structure of (E) 1 {2 [(5,5 di­methyl 1,3,2 dioxaphosphinan 2 yl)­­oxy]naphthalen 1 yl} N (4 fluoro­phen­yl)methanimine

Geometry . All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes.

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6 (4 Meth­oxy­phenyl) 4 phenyl 2 (pyrrolidin 1 yl)­nicotino­nitrile

6 (4 Meth­oxy­phenyl) 4 phenyl 2 (pyrrolidin 1 yl)­nicotino­nitrile

structure (Fun et al., 1996). The methoxy group is coplanar with the attached phenyl ring. In the crystal, inversion-related molecules exist as CÐH N hydrogen-bonded dimers, i.e. the molecules form a cyclic dimer (Table 2) with graph-set descriptor R 2 2 (26) (Bernstein et al., 1995). The ring for R 2 2 (26)

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Synthesis and anti microbial activity of novel mannich bases containing 2  phenoxy 1, 3, 2 dioxa phospholanes and Indole systems

Synthesis and anti microbial activity of novel mannich bases containing 2 phenoxy 1, 3, 2 dioxa phospholanes and Indole systems

New mannich bases of 2-phenoxy-1,3,2-dioxaphospholanes derivatives (4R, 5R) - N’4, N’5-bis-(2-oxo-1-(piperidin- 1-ylmethyl) / (morpholino methyl) / (4-methyl piperazin-1-ylmethyl) indolin-3-ylidene) - 2-(4-substituted phenoxy)-1, 3, 2-dioxa phospholane-4, 5-dicarbohydrazide-2-oxide 6(a-g) were prepared by the condensation reaction between (4R, 5R) -2-(4-substituted phenoxy)-1, 3, 2-dioxa phospholane-4, 5-dicarbohydrazide-2-oxide 3(a-e) with Isatin (4) yielded the corresponding (4R, 5R) - N’4, N’5-bis-(2-oxo indolin-3-ylidene) - 2-(4-substituted phenoxy)-1, 3, 2- Dioxaphospholane-4, 5-dicarbohydrazide-2-oxide 5(a-e). This was allowed to undergo the Mannich reaction with different Secondary Amines namely: piperidine, morpholine and N-methyl piperazine in the presence of formaldehyde in DMF to give corresponding hydrazides 6(a-g). The structure of these newly synthesized compounds was characterized by 1 H-NMR, Mass, IR, C 13 -NMR and P 31 -NMR Spectral data.These newly synthesized compounds 6(a-g) were screened for their antibacterial and antifungal activity.
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Bis{2 [2,5 bis­­(pyridin 2 yl) 1H imidazol 4 yl]pyridinium} tetra­cyanidoplatinate(II) tetra­hydrate

Bis{2 [2,5 bis­­(pyridin 2 yl) 1H imidazol 4 yl]pyridinium} tetra­cyanidoplatinate(II) tetra­hydrate

2.000 (4) A ˚ . In the cation, there is an N—H N hydrogen bond linking adjacent pyridinium and pyridine rings in positions 4 and 5. Despite this, the organic component is non-planar, as shown by the dihedral angles of 10.3 (2), 6.60 (19) and 15.66 (18) between the planes of the central

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2 (2H Benzotriazol 2 yl) 6 [(di­cyclo­hexyl­amino)­meth­yl] 4 (2,4,4 tri­methyl­pentan 2 yl)phenol

2 (2H Benzotriazol 2 yl) 6 [(di­cyclo­hexyl­amino)­meth­yl] 4 (2,4,4 tri­methyl­pentan 2 yl)phenol

C18 0.135 (2) 0.0608 (11) 0.0662 (12) −0.0351 (12) 0.0065 (12) 0.0075 (9) C19 0.0854 (15) 0.0958 (16) 0.0957 (15) 0.0206 (13) −0.0294 (12) 0.0083 (14) C20 0.0955 (15) 0.0829 (13) 0.0591 (10) −0.0009 (12) 0.0053 (10) −0.0073 (10) C21 0.0364 (7) 0.0554 (9) 0.0570 (8) 0.0070 (6) −0.0011 (6) −0.0177 (7) C22 0.0397 (7) 0.0423 (7) 0.0511 (7) 0.0031 (6) 0.0032 (6) −0.0042 (6) C23 0.0589 (9) 0.0560 (9) 0.0491 (8) −0.0063 (7) 0.0001 (6) −0.0058 (7) C24 0.0842 (13) 0.0750 (12) 0.0471 (8) 0.0031 (10) 0.0031 (8) −0.0055 (8) C25 0.0908 (14) 0.0731 (12) 0.0619 (10) 0.0196 (11) 0.0284 (9) 0.0063 (10) C26 0.0639 (11) 0.0576 (10) 0.0926 (14) 0.0064 (8) 0.0303 (10) 0.0143 (10) C27 0.0420 (8) 0.0504 (8) 0.0717 (10) −0.0007 (7) 0.0100 (7) −0.0044 (8) C28 0.0408 (7) 0.0453 (7) 0.0440 (7) 0.0028 (6) 0.0037 (5) −0.0075 (6) C29 0.0575 (10) 0.0680 (10) 0.0654 (10) −0.0119 (8) 0.0015 (8) 0.0047 (9) C30 0.0976 (15) 0.0610 (11) 0.0804 (13) −0.0151 (10) −0.0113 (11) 0.0129 (10) C31 0.0965 (15) 0.0628 (11) 0.0628 (11) 0.0076 (10) −0.0159 (10) 0.0063 (9) C32 0.0579 (10) 0.0692 (10) 0.0612 (9) 0.0192 (8) −0.0101 (7) −0.0075 (8) C33 0.0438 (8) 0.0550 (9) 0.0590 (8) 0.0043 (7) −0.0032 (6) −0.0037 (7)
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