[PDF] Top 20 Alloantigen specific regulatory T cells generated with a chimeric antigen receptor
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Alloantigen specific regulatory T cells generated with a chimeric antigen receptor
... CARs specific for model antigens. Expres- sion of a trinitrophenol–specific CAR with a CD28 trans- membrane domain and FCγR signaling domains enabled mouse Tregs to home to the site of disease and protect ... See full document
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T cells expressing chimeric antigen receptor promote immune tolerance
... following T cell activation in response to anti-CD3/CD28 beads (Figure ...become alloantigen specific, our findings are con- sistent with the possibility that mAbCAR stimulation could facilitate or ... See full document
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Chimeric antigen receptor-engineered T cells for cancer immunotherapy: progress and challenges
... CAR-modified T cells constitute a very appealing approach to cancer ...CAR-modified T cells, some severe adverse reactions were reported ...chemokine receptor for T cells ... See full document
7
Incorporation of a hinge domain improves the expansion of chimeric antigen receptor T cells
... CAR T cells and target cells; for example, to overcome steric hindrance in MUC1-specific CAR, a flexible and elongated hinge of the IgD isotype can be inserted [20]; (3) reducing the distance ... See full document
11
From bench to bed: the tumor immune microenvironment and current immunotherapeutic strategies for hepatocellular carcinoma
... uses chimeric antigen receptor-modified T cells (CAR-T) or genetically modified NK cells, has been shown to be a promising strategy for the treatment of ...tumor ... See full document
21
Chimeric antigen receptor costimulation domains modulate human regulatory T cell function
... CAR T cells ...observed T cell infiltration into the skin grafts of mice that received either EGFR CAR-Tregs or CAR-Teffs, though greater numbers of Teffs than Tregs accumulated in the grafts (Figure ... See full document
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A new insight in chimeric antigen receptor-engineered T cells for cancer immunotherapy
... adoptive T-cell therapy are sev- eral hundred times higher than the baseline level, which typically causes a clinical syndrome including fever, hypotension, and neurological changes, potentially leading to rapid ... See full document
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Chimeric antigen receptor T cells: a novel therapy for solid tumors
... EGFRvIII cells controlled tumor growth and increased median survival ...CAR-T cells, and the results of skin graft assay demonstrated that no significant lymphocytic infiltrate by ...CAR-T ... See full document
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Cocktail treatment with EGFR-specific and CD133-specific chimeric antigen receptor-modified T cells in a patient with advanced cholangiocarcinoma
... CART cells in vivo is a critical determinant of therapeutic efficacy [18], in this case, the CAR transgene copy number in PB ascended to peak level immediately after the beginning of CART-EGFR cell infusion, ... See full document
11
Safety, tumor trafficking and immunogenicity of chimeric antigen receptor (CAR)-T cells specific for TAG-72 in colorectal cancer
... Concurrent with these trials in HIV infection, CAR-T cell approaches targeting solid tumors were also pursued. T cells expressing scFv-based CARs had demonstrated pre- clinical activity against a ... See full document
14
Cancer biomarkers for targeted therapy
... bispecific T cell engagers, and antibody-drug ...maturation antigen, and CD138 are targets for cancer immunotherapeutic agents, including the chimeric antigen receptor - engineered ... See full document
7
MAGE-A1 in lung adenocarcinoma as a promising target of chimeric antigen receptor T cells
... factor receptor (EGFR) in a clinical trial showed a good response in EGFR-expressing advanced relapsed/refractory NSCLC, and Li et ...3 T cells displayed promising therapeutic effectiveness for the ... See full document
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Rejection of Experimental Hodgkins Lymphoma by T Cells Engineered with a CD19 Chimeric Antigen Receptor
... 6% cells expressing CD34 as a marker of ...transduced cells in the total population by CD34 selec- tion improved levels of specific lysis (Figure ...CD34+ cells and level of specific ... See full document
9
T Cells Bearing a Chimeric Antigen Receptor Against the Tumor Vasculature Destroy the Tumor Endothelium and Result in Tumor Regression
... CAR T cell-based immunotherapy for individuals with advanced ...CAR T cell therapy for the treatment of acute lymphocytic ...CAR T cells directed against the ganglioside, ...CAR T cell ... See full document
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Designed ankyrin repeat proteins are effective targeting elements for chimeric antigen receptors
... tumor cells was verified via flow cytometry (Fig. 4a). Murine DARPin28z CAR-T cells showed minimal killing of HER2-negative tumor cells ...tumor cells at effector(E):target(T) ... See full document
11
CRISPR-Cas, a robust gene-editing technology in the era of modern cancer immunotherapy
... tumor-specific T-cells into patients, a so called “adoptive cell transfer”, or ACT, ...allogeneic T-cells is dependent on the employment of a gene-editing tool to modify donor-extracted ... See full document
17
Mesothelin is a target of chimeric antigen receptor T cells for treating gastric cancer
... CAR T cells have achieved re- markable success in acute lymphoblastic ...CAR T cells to treat solid cancer [33, ...CAR T cells M28z10 compared with the second-generation M28z CAR ... See full document
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Multi-antigen-targeted chimeric antigen receptor T cells for cancer therapy
... CAR-T cells is being tested as a strat- egy to reduce relapse ...CAR-T cells: mixtures of two engi- neered T cell lines, each of which expresses a distinct ... See full document
10
Engineering CAR-T cells
... Chimeric antigen receptors (CARs) are engineered receptors that can graft an arbitrary specificity onto an immune effector cell (T ...extracellular antigen recognition domain of the ... See full document
6
Systematic testing and specificity mapping of alloantigen-specific chimeric antigen receptors in regulatory T cells
... but T cells expressing humanized or fully human CARs have increased cell persistence and efficacy (40), and decreased side effects (17, 19–22, ...+ cells 16 hours after coculture with HLA-A*02:01 ... See full document
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