[PDF] Top 20 Allosteric induction of the CD4 bound conformation of HIV 1 Gp120
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Allosteric induction of the CD4 bound conformation of HIV 1 Gp120
... of gp120 CDC451 to each of the phage-displayed peptides were performed at a concentrations ranging between ...concentrations. gp120 CDC451 was injected over the immobilized phages for 2 min at a flow rate ... See full document
16
The HIV-1 gp120 CD4-Bound Conformation Is Preferentially Targeted by Antibody-Dependent Cellular Cytotoxicity-Mediating Antibodies in Sera from HIV-1-Infected Individuals
... those CD4-induced HIV-1 Env epitopes and were proposed to play a role in reducing the susceptibility of infected cells to ADCC medi- ated by this class of ...recognizing CD4-induced ... See full document
7
Range of CD4-Bound Conformations of HIV-1 gp120, as Defined Using Conditional CD4-Induced Antibodies
... The HIV envelope binds cellular CD4 and undergoes a range of conformational changes that lead to membrane fusion and deliv- ery of the viral nucleocapsid into the cellular ...to CD4 reveals cryptic ... See full document
13
Transitions to and from the CD4-Bound Conformation Are Modulated by a Single-Residue Change in the Human Immunodeficiency Virus Type 1 gp120 Inner Domain
... loop-deleted HIV-1 gp120 glycoprotein with intact N and C termini in complex with two-domain CD4 and the 48d Fab fragment was used as a starting point for ...The gp120 glycoprotein with ... See full document
15
Mutagenic Stabilization and/or Disruption of a CD4-Bound State Reveals Distinct Conformations of the Human Immunodeficiency Virus Type 1 gp120 Envelope Glycoprotein
... of CD4-bound gp120 (95), suggesting that these antibodies might recognize distinct con- formations of ...alter gp120 so that the free molecule assumed a conformation that more closely ... See full document
12
Local Conformational Stability of HIV-1 gp120 in Unliganded and CD4-Bound States as Defined by Amide Hydrogen/Deuterium Exchange
... of HIV-1 gp120 thus provides not only definition of local conformational flexibility but also insight ...to CD4-bound states of ...of HIV-1 gp120 consists of a ... See full document
11
PGV04, an HIV-1 gp120 CD4 Binding Site Antibody, Is Broad and Potent in Neutralization but Does Not Induce Conformational Changes Characteristic of CD4
... monomeric gp120. CD4-IgG, VRC01, and NIH45-46 enhance ex- posure of the coreceptor binding site as assessed by 17b binding, while PGV04, VRC03, and b12 do ...to gp120 is much less than that ... See full document
10
Conformation-Dependent Recognition of HIV gp120 by Designed Ankyrin Repeat Proteins Provides Access to Novel HIV Entry Inhibitors
... novel gp120-directed binding molecules with HIV entry-inhibiting ...for HIV envelope inhibitor design, as their high-affinity binding differs from that of ...novel gp120-reactive molecules ... See full document
14
Incomplete Downregulation of CD4 Expression Affects HIV-1 Env Conformation and Antibody-Dependent Cellular Cytotoxicity Responses
... ABSTRACT HIV-1-infected cells expressing envelope glycoproteins (Env) in the CD4- bound conformation on their surfaces are targeted by antibody-dependent cellular cyto- toxicity (ADCC) ... See full document
16
The Highly Conserved Layer-3 Component of the HIV-1 gp120 Inner Domain Is Critical for CD4-Required Conformational Transitions
... type 1 (HIV-1) mediates virus entry into host cells. CD4 engagement with the gp120 exterior envelope glycoprotein subunit represents the first step during HIV-1 ...entry. ... See full document
14
Identification and Characterization of an Immunogenic Hybrid Epitope Formed by both HIV gp120 and Human CD4 Proteins
... from HIV-infected humans bind conserved transition state (CD4 induced [CD4i]) domains on the HIV envelope glycoprotein, gp120, and demonstrate extreme dependence on the formation of a ... See full document
9
HIV-1 gp41 Residues Modulate CD4-Induced Conformational Changes in the Envelope Glycoprotein and Evolution of a Relaxed Conformation of gp120
... to CD4-mediated inactivation via reduced conformational triggering of gp41 to the ...tolerate gp120 mutations that relax the native trimer through the release of V1/V2, which facilitates binding to ...to ... See full document
17
Structure of an HIV-2 gp120 in Complex with CD4
... 43. Wu H, Kwong PD, Hendrickson WA. 1997. Dimeric association and segmental variability in the structure of human CD4. Nature 387:527–530. http://dx.doi.org/10.1038/387527a0. 44. Do Kwon Y, Pancera M, Acharya P, ... See full document
7
Conformational alterations in the CD4 binding cavity of HIV 1 gp120 influencing gp120 CD4 interactions and fusogenicity of HIV 1 envelopes derived from brain and other tissues
... of gp120 were generated by our recently validated homology modelling ...cell-surface CD4, bind directly to soluble CD4, and bind to the Env mAb IgG1b12 whose epitope overlaps the gp120 ... See full document
10
Antibodies to the CD4-binding site of HIV-1 gp120 suppress gp120-specific CD4 T cell response while enhancing antibody response
... and CD4 T cell responses to gp120 has been demonstrated in vitro with human CD4 T cell lines or clones [1,2,8,12], the in vivo effects of the anti-CD4bs Abs have yet to be ...the induction of ... See full document
9
Spectroscopic and Electrochemical Characterization of CD4 Binding Site of HIV-1 Exterior Envelope gp120
... 3.3 Ion-exchange chromatography As the next step, entire CD4 binding site was dissolved in ACS water in concentration of 1 mg.mL -1 and directly analysed using ion-exchange chromatography (IEC) using ... See full document
12
Structures of the CCR5 N terminus and of a tyrosine-sulfated antibody with HIV-1 gp120 and CD4
... S2) Huang CC, Lam SN, Acharya P, Tang M, Xiang SH, Hussan SS, Stanfield RL, Robinson J, Sodroski J, Wilson IA, Wyatt R, Bewley CA, Kwong PD. Structures of the CCR5 N terminus and of a tyrosine-sulfated antibody with ... See full document
6
Immunization with a soluble CD4-gp120 complex preferentially induces neutralizing anti-human immunodeficiency virus type 1 antibodies directed to conformation-dependent epitopes of gp120.
... Conformational epitope on gpl20 important in CD4 binding and human immunodeficiency virus type 1 neutralization identified by a human monoclonal antibody. Broadly neutralizing antibodies[r] ... See full document
9
HIV-1 Resistance to Maraviroc Conferred by a CD4 Binding Site Mutation in the Envelope Glycoprotein gp120
... diverse HIV-1 isolates appear to fol- low different evolutionary pathways to MVC resistance, but all have been linked to emergence of a V3 loop ...untreated HIV-1 populations, suggesting ... See full document
12
Binding of the Mannose-Specific Lectin, Griffithsin, to HIV-1 gp120 Exposes the CD4-Binding Site
... on HIV-1 gp120 play an important role in shielding neutralization-sensitive epitopes from antibody ...with HIV-1 gp120 and its effects on exposure of the CD4-binding site ... See full document
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