[PDF] Top 20 Alpha-Synuclein Toxicity is Caused by Mitochondrial Dysfunction
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Alpha-Synuclein Toxicity is Caused by Mitochondrial Dysfunction
... aSyn toxicity using the high expression model (44, ...increased toxicity when yeast cells were grown in glucose with low expression of aSyn (Figure ...more toxicity in WT yeast grown with glycerol ... See full document
130
Early-onset Parkinson disease caused by a mutation in CHCHD2 and mitochondrial dysfunction
... Reductions in complexes I and IV subunits were consistent with reduced activities of these complexes in patient cells. Although reduced complex IV activity has been previously reported in PD, there is much less evidence ... See full document
12
TDP-43 Potentiates Alpha-synuclein Toxicity to Dopaminergic Neurons in Transgenic Mice
... (49, 50). Deletion of TDP-43 causes a defect at the neuromuscular junction in Drosophila melanogaster (51). Constitutive or temporal deletion of TDP-43 in mice induces severe phenotypes (52, 53), underscor- ing the ... See full document
10
Evaluation of Mitochondrial Dysfunction and α-Synuclein Aggregation in Yeast Models of Parkinson’s Disease
... be caused by familial mutations, but chemical agents can be used to create PD-like ...(MPTP) caused acute and irreversible damage to the SNpc without ...inhibit mitochondrial complex I activity, ... See full document
23
Monomeric alpha-synuclein exerts a physiological role in brain ATP synthase
... were caused by a lack of ␣-synuclein and were not an indirect consequence or downstream effect of synuclein deficiency, exogenous mono- meric ␣ -synuclein was ...the mitochondrial ... See full document
12
Uptake and mitochondrial dysfunction of alpha synuclein in human astrocytes, cortical neurons and fibroblasts
... Recombinant α-synuclein was expressed in Escherichia coli BL21(DE3) transformed with the pET11d vector containing the human α-synuclein cDNA described previously [16]. For uptake of recombinant α-syn in ... See full document
9
NADPH oxidases in Parkinson’s disease: a systematic review
... of alpha-synuclein in sporadic PD emerged from the asso- ciation between polymorphisms regulating SNCA levels and sporadic PD [14, 15], supporting that alpha- synuclein level is instrumental ... See full document
18
Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity
... We found significant down-regulation of proteasome activities in Ctsd-/- brains. The reduction of proteasome activity may be due to reduced expression of UPS regula- tors and proteasome subunits, inactivating ... See full document
18
Insight Into Parkinson's Disease Using Yeast as a Model to Evaluate the Role of Autophagy Genes in alpha-Synuclein Toxicity
... α- synuclein, for degradation (Kitada et ...proteasome dysfunction is a cause of PD. Furthermore, α- synuclein found in LBs reveal non-degraded and multi- ubiquinated α-synuclein – reinforcing ... See full document
18
Alpha-synuclein oligomer-selective antibodies reduce intracellular accumulation and mitochondrial impairment in alpha-synuclein exposed astrocytes
... effects of three different oligomer-selective antibodies: mAb49G, mab38E2, and mAb47, on α-syn-induced pathology in a co-culture system of astrocytes, neurons, and oligodendrocytes. The astrocytes were found to in- gest ... See full document
14
Posttranslational modification and mutation of histidine 50 trigger alpha synuclein aggregation and toxicity
... aggregated alpha synuclein (aSyn), along with other proteins such as neurofilament subunits and ubiquitin ...stress, mitochondrial impairment, and abnormal protein processing have been closely ... See full document
16
alpha-Synuclein shares physical and functional homology with 14-3-3 proteins
... was toxicity. The ability of a-synuclein to inhibit PKC and to bind to BAD suggested to us that overexpression of a-synuclein might be ...induces toxicity, apparently by increasing necrosis, ... See full document
10
Alpha synuclein truncation and disease
... vesicles, alpha- synuclein adopts a conformation that has a high al- pha-helical propensity [44,45], and a fraction of neu- ronal alpha-synuclein has been found to associate with membranes in ... See full document
11
Vanadium induces liver toxicity through reductive activation by glutathione and mitochondrial dysfunction
... 2.7. Mitochondrial Membrane Potential Assay Mitochondrial uptake of the cationic fluorescent dye, rhodamine123, has been used for estimation of mito- chondrial membrane potential ...of mitochondrial ... See full document
8
The role of alpha-synuclein and other
... MPTP toxicity of dopaminergic neurones in substantia nigra pars compacta of gamma-synuclein, alpha-synuclein and double alpha/gamma-synuclein null mutant ... See full document
15
Genetic Evidence in Yeast Model Implicates Autophagy in the Degradation of Parkinson's Disease Protein alpha-Synuclein
... In strong support of our hypothesis, our first notable finding was that fusion genes regulate α-synuclein, as vam3Δ and vam7Δ affected both α-synuclein localization and accumulation. Previously, only ... See full document
10
Metabolic profiling of hypoxic cells revealed a catabolic signature required for cell survival
... signatures of normoxic and hypoxic cells could be defined. The top-rank compounds (p-value ,0.05 and fold change .1.5) found in hypoxic cell line showed extensive alterations of amino acids and fatty acid/phospholipids ... See full document
10
Regulation of mitochondrial dynamics in adipose tissue
... In Chapter 2, higher adiposity was shown to increase the expression of mitochondrial fission (Drp1 and Fis1) and fusion genes (Mfn2 and Opa1) in overweight and obese AbSc AT (Figures 2.4 and 2.5). Obesity is known ... See full document
291
Structural Remodeling Of Alpha-Synuclein By Small Molecules: A Novel Path To Neuroprotective Therapeutics
... (Life Technologies, H3570), mounted with Fluormount G (Southern Biotech, 0100-01) and cover- slipped. I mages were acquired using a Nikon A1RSI laser scanning confocal microscope. In Vitro Degradation Assay. Purified ... See full document
178
-induced neuronal apoptosis and synaptotoxicity in primary cultured cortical neurons possibly via modulating both PI3K/AKT and ERK signaling pathways
... Alzheimer’s disease (AD) is an age-related neu- rodegenerative disease featured by extracellu- lar β-amyloid (Aβ) peptide deposition and intra- cellular neurofibrillar tangles, which is followed by loss of cortex and ... See full document
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