[PDF] Top 20 Alteration of a single serine in the basic domain of the Epstein-Barr virus ZEBRA protein separates its functions of transcriptional activation and disruption of latency.
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Alteration of a single serine in the basic domain of the Epstein-Barr virus ZEBRA protein separates its functions of transcriptional activation and disruption of latency.
... of ZEBRA and Z(S186A) to disrupt latency of EBV. The ZEBRA protein has the capacity to induce lytic cycle expression of EBV in several latently infected cell ...This disruption of ... See full document
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Amino Acid Substitutions Reveal Distinct Functions of Serine 186 of the ZEBRA Protein in Activation of Early Lytic Cycle Genes and Synergy with the Epstein-Barr Virus R Transactivator
... The ZEBRA protein, a member of the basic-zipper (bZIP) family of transcriptional activators, shows extensive amino acid identity with cellular bZIP proteins such as c-Fos/c-Jun in the ... See full document
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Amino Acids in the Basic Domain of Epstein-Barr Virus ZEBRA Protein Play Distinct Roles in DNA Binding, Activation of Early Lytic Gene Expression, and Promotion of Viral DNA Replication
... The ZEBRA protein of Epstein-Barr virus (EBV) drives the viral lytic cycle ...of ZEBRA to recognize specific DNA sequences resides in amino acids 178 to 194, a region in which 9 ... See full document
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Histone Acetylation and Reactivation of Epstein-Barr Virus from Latency
... One notable difference was that in the transient assay ex- periments, both of the ZIIIA and ZIIIB elements had been found to be essential for efficient autoactivation of the pro- moter by BZLF1 (11); since ZIIIB was ... See full document
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Chromatin Profiling of Epstein-Barr Virus Latency Control Region
... transcription activation of Cp. Several functions have been attributed to CTCF, including enhancer blocking, insulator binding, and interchromosome ...EBNA1 activation of Cp ...CTCF protein, ... See full document
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trans-Repression of Protein Expression Dependent on the Epstein-Barr Virus Promoter Wp during Latency
... growth. Latency III is also supported within a subset of B-cell lines derived from Burkitt lymphomas (BLs) ...EBV protein ex- pression is believed to be silenced (latency 0) as infected B cells enter ... See full document
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Three pathways of Epstein-Barr virus gene activation from EBNA1-positive latency in B lymphocytes.
... In contrast, Burkitt's lymphoma-derived cell lines retaining the tumor biopsy cell phenotype express only one of the latent proteins, the nuclear antigen EBNA1; such cells do not enter t[r] ... See full document
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The Epstein-Barr virus nuclear protein 1 promoter active in type I latency is autoregulated.
... Fp-directed expression of hGH was used as an indicator of promoter activity in type I A and type III B latently infected Mutu BL cells and in EBV-negative Louckes BL cells C following tr[r] ... See full document
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Interferon γ inducible protein 16 (IFI16) is required for the maintenance of Epstein Barr virus latency
... Epstein-Barr virus is a lymphotropic herpesvirus that es- tablishes a lifelong infection in its host once it is ac- ...to its ubiquitous presence in different tumor types and also for ... See full document
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Functions of the Epstein-Barr Virus EBNA1 Protein in Viral Reactivation and Lytic Infection
... the disruption of PML ...BZLF1 protein expression compared to infection with the wild-type ...to its other important roles in lytic activation (2, ... See full document
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Protein Kinase C-Independent Activation of the Epstein-Barr Virus Lytic Cycle
... PKC activation was not sufficient for activation of the lytic cycle in this cell ...same virus strain are often refrac- tory to chemical induction (reference 36 and data not shown), it was feasible ... See full document
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Identification of Host Biomarkers of Epstein Barr Virus Latency IIb and Latency III
... proliferating latency IIb cells. To assay this at the protein level, we conducted FACS analysis on early proliferating latency IIb cells (day 7 postinfection) and donor matched LCLs ( ⬎ 35 days ... See full document
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Cyclic AMP-responsive element-dependent activation of Epstein-Barr virus zebra promoter by human herpesvirus 6.
... CREB protein by PKA ...for activation by ...Zp activation following HHV-6 infection, since (i) mutation of the CRE site within the ZII domain of Zp abolished responsive- ness to HHV-6 ... See full document
8
Mutation of a Single Amino Acid Residue in the Basic Region of the Epstein-Barr Virus (EBV) Lytic Cycle Switch Protein Zta (BZLF1) Prevents Reactivation of EBV from Latency
... The DNA-binding function of Zta probably contributes to its ability to initiate and complete the viral lytic cycle. Specif- ically, Zta interacts with ZREs in several immediate-early and early viral genes (27, 29) ... See full document
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The signaling pathways of Epstein-Barr virus-encoded latent membrane protein 2A (LMP2A) in latency and cancer
... through protein kinase Syk and Lyn, which play a crucial role in cell survival ...PI3-K/Akt activation leads to an enhanced cell growth and anti-apoptotic effect in B-cells, lymphoma, gastric carcinoma, and ... See full document
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An Epstein-Barr Virus Protein Interacts with Notch
... EBNA2-independent activation of the LMP1 promot- er and binds ATF1, ATF2, and c-Jun ...cytoplasmic protein Deltex, which inhibits activation of the c-Jun terminal kinase (JNK), and recent studies ... See full document
12
Constitutive Interferon-Inducible Protein 16-Inflammasome Activation during Epstein-Barr Virus Latency I, II, and III in B and Epithelial Cells
... HIN domain residues and the sugar-phosphate backbone of the dsDNA ...constitutive activation of IFI16-mediated inflammasome during EBV latency in B and epithelial cells with latency I, II, and ... See full document
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Promoter Sequences Required for Reactivation of Epstein-Barr Virus from Latency
... When introduced singly, none of the mutations studied here resulted in a constitutively active Zp promoter. The MV mu- tation raised the background expression from Zp about five- fold and increased the peak anti-Ig ... See full document
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Identification of Acidic and Aromatic Residues in the Zta Activation Domain Essential for Epstein-Barr Virus Reactivation
... transcription activation of the EBV BHLF1 ...a protein of unknown ...in activation of BHLF1- CAT (Fig. 1B). Single amino acid substitutions at positions W74 and F26 had less dramatic effects ... See full document
14
Epstein-Barr virus nuclear antigen 3C is a transcriptional regulator.
... one protein can be bound at a time or only one complex can interact with DNA because of adjacent binding sites in the ...greater activation by EBNA-3C can often be obtained when the RBP-J k site is deleted ... See full document
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