[PDF] Top 20 Altered intracellular Ca2+ handling in heart failure
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Altered intracellular Ca2+ handling in heart failure
... et al. later obtained conflicting results using the same model (46). Attempts to reproduce the altered channel-gating property seen in HF have not been successful in intact myocytes. Indepen- dent groups have ... See full document
10
Mechanisms of anthracycline induced dysfunction of ca2+ handling proteins in the heart
... Several proteins important in intracellular Ca 2+ signalling have been identified as drug binding targets, including the cardiac ryanodine receptor Ca2+ release channel RyR2, the Ca2+ bi[r] ... See full document
246
Diminished post rest potentiation of contractile force in human dilated cardiomyopathy Functional evidence for alterations in intracellular Ca2+ handling
... with heart failure before transplanta- tion. Heart failure patient’s data, hemodynamic parameters and pre- medications are shown in Table ... See full document
14
NOX Inhibition Improves β-Adrenergic Stimulated Contractility and Intracellular Calcium Handling in the Aged Heart
... the heart, aging increases the risk of ischemic disease, atrial fibrillation and heart ...the heart more vulnerable to stress and contributes to increased cardiovascular mortality and ... See full document
31
Ca2+ and mitochondrial dependent cardiomyocyte necrosis as a primary mediator of heart failure
... antagonists, demonstrating a proximal relationship among b-adrenergic receptor function, Ca 2+ handling, and heart failure progression through necrotic cell loss. Mechanistically, loss of cyclophilin ... See full document
15
Altered sarcoplasmic reticulum Ca2(+) ATPase gene expression in the human ventricle during end stage heart failure
... control heart samples using a rat cardiac SR Ca2(+)-ATPase cDNA ...the Ca2(+)-ATPase relative to both the 18S ribosomal RNA and the myosin heavy chain mRNA in LV specimens of patients with ... See full document
6
Effects of temperature on intracellular [Ca2+] in trout atrial myocytes
... trout heart preparations in situ falls off at temperatures above 18°C (Farrell et ...cardiac failure may be a critical factor when salmon are exposed to temperatures that exceed their ... See full document
10
Dichotomy of Ca2+ in the heart: contraction versus intracellular signaling
... deacetylase 5 (HDAC5) nuclear shuttling represent a critical Ca 2+ -dependent signaling circuit for controlling cardiac hypertrophy and heart failure, yet the mechanism of activation by Ca 2+ is not known. ... See full document
5
Review Article Ca 2+ and ion channels in hypoxia-mediated pulmonary hypertension
... Compared with Kv channels, little is known about the roles and functions of TRPC proteins as well as its upregulation mechanisms in the development of chronic pulmonary hyperten- sion. Yu et al was the first to ... See full document
12
Decreased cardiac L type Ca2+ channel activity induces hypertrophy and heart failure in mice
... with heart failure, and their overall therapeutic profile remains nebulous given differential effects in the vasculature when compared with those in ...graded heart-specific gene deletion (termed ... See full document
12
Cardiovascular science: opportunities for translating research into improved care
... cause heart failure and channelopathies that underlie cardiac arrhythmias, have been ...For heart failure, recent work suggests that cardiac regeneration using stem/progenitor cells, gene ... See full document
6
Mitochondria, calcium, and tumor suppressor Fus1: At the crossroad of cancer, inflammation and autoimmunity
... High proliferative potential is a key energy-demanding feature shared by cancer cells and activated T lymphocytes. Switch of a metabolic state mediated by alterations in mitochondrial homeostasis plays a fundamental role ... See full document
19
Translating intracellular calcium signaling into models
... signaling suffers from two major shortcomings. Firstly, it is not clear a priori how many compartments are needed to account for experimental measurements. Different models use different numbers of compartments and yet ... See full document
14
Endothelin induced increases in vascular smooth muscle Ca2+ do not depend on dihydropyridine sensitive Ca2+ channels
... dihydropyridine-sensitive Ca2+ channels in cultured vascular smooth muscle (VSM) ...cell Ca2+ can be altered in VSM by activation of voltage- operated Ca2+ ...dihydropyridine Ca2+ ... See full document
6
Altered cardiac excitation–contraction coupling in mutant mice with familial hypertrophic cardiomyopathy
... peak intracellular Ca 2+ ([Ca 2+ ] i ) was higher in mutant muscles than in the wild-type (P < ...both altered in FHC mutant mice: more Ca 2+ is mobilized to generate force, but this does not suffice to ... See full document
7
Calcium mobilization via intracellular ion channels, store organization and mitochondria in smooth muscle
... 11 Calcium Mobilization via Intracellular Ion Channels, Store Organization… 245 raded Ca2+ Release, Ca2+ Waves and Local Ca2+ Events G from a Luminally-Continuous Store If the Ca2+ sto[r] ... See full document
22
Effect of a 6 month pedometer based walking intervention on functional capacity in patients with chronic heart failure with reduced (HFrEF) and with preserved (HFpEF) ejection fraction: study protocol for two multicenter randomized controlled trials
... chronic heart failure with reduced ejection fraction (HFrEF), the other in patients with chronic heart failure with preserved ejection fraction ...chronic heart failure who will ... See full document
10
Mitochondrial dysfunction in pathophysiology of heart failure
... failing heart, damage caused by excessive mtROS is evi- dent in human patients and animal models ...of heart failure (118, 121, ...of heart failure ...mouse heart leads to ... See full document
12
Roles of Ca2+ and Na+ on the modulation of antidiuretic hormone action on urea permeability in toad urinary bladder
... of Ca2+ and Na+ in the stimulation-permeability coupling sequences by which antidiuretic hormone (ADH) induces a cyclic AMP (cAMP)-mediated increase in urea permeability in toad urinary ...or Ca2+ or ... See full document
12
Transverse tubule remodelling: a cellular pathology driven by both sides of the plasmalemma?
... Disrupted local Ca 2+ signalling has been previously docu- mented in the myocytes from the failing human heart (Beuckelmann et al. 1992; Lindner et al. 2002; Louch et al. 2004). However, there have been ... See full document
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