[PDF] Top 20 D amphetamine and antipsychotic drug effects on latent inhibition in mice lacking dopamine D2 receptors
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D amphetamine and antipsychotic drug effects on latent inhibition in mice lacking dopamine D2 receptors
... For mice receiving AMP in combination with either haloperidol, clozapine, or SKF83566, the drug was adminis- tered 5 min before AMP, with control mice receiving a matched number of vehicle ... See full document
9
Potentiation of latent inhibition by haloperidol and clozapine is attenuated in Dopamine D2 receptor (Drd 2) deficient mice: Do antipsychotics influence learning to ignore irrelevant stimuli via both Drd 2 and non Drd 2 mechanisms?
... peptide receptors but it is Drd-2 blockade that correlates signifi- cantly with clinical potency (Meltzer et ...all antipsychotic drugs are dopamine receptor Drd-2 antagonists it is inferred that ... See full document
5
Sensitivity to Dopamine D1/D2 Receptor Stimulation in Mice Lacking Connexin-32 or Connexin-36
... and D2 receptor families both serve an important function in regards to motor ...dependent effects on motor behavior can be observed after stimulation of DA receptors with indirect agonists ...(e.g., ... See full document
38
Sensorimotor gating in NTS1 and NTS2 null mice: effects of d amphetamine, dizocilpine, clozapine and NT69L
... with antipsychotic drugs that target the DA neurotransmitter system (Galletly et ...inhibitory D2 auto-receptors (Fawaz et ...successful amphetamine-induced PPI disruption, as well as the ... See full document
8
Knocking Down the DRD2 by shRNA Expressing Plasmids in the Nucleus Accumbens Prevented the Disrupting Effect of Apomorphine on Prepulse Inhibition in Rat
... Traditionally, dopamine D2 receptors antagonists were prescribed for treating ...side effects of these drugs such as dystonia; parkinsonism; and tardive dyskinesia, due to the binding of these ... See full document
8
Activation of the dopamine 1 and dopamine 5 receptors increase skeletal muscle mass and force production under non atrophying and atrophying conditions
... gical effects. In the brain, dopamine controls a multitude of functions including locomotor activity, cognition, emotion, positive reinforcement, food intake and endo- crine ...periphery, dopamine ... See full document
8
Adjuvant TACE inhibitor treatment improves the outcome of TLR2 / mice with experimental pneumococcal meningitis
... 37°C for 24 h. Cell free CSF was obtained by centrifuga- tion at 800 × g for 7 min (room temperature) and samples were stored at -20°C until cytokine determination. For histology, brains were fixed in 4% ... See full document
9
Comparison of Effects of Light Anesthetics, Diethyl Ether and Carbon Dioxide, on Hypothalamic Paraventricular Nucleus D1 and D2 Dopamine Receptors- and Glucosensitive Neurons-Induced Food Intake in Fasted Conscious Rats
... Probably the food intake decreases under brief anes- thesia as a result of masking of the stimulus signal. For example, PVN and lateral hypothalamus received NPY-containing neuron projections from arcuate nucle- us. It ... See full document
6
QSAR and Docking Studies on 1,2-benzisoxazole Derivatives for Antipsychotic activity against Dopamine receptor (D2)
... training set and 68.33% (Pred_r 2 = 0.6833, representing external validation) in test set using sphere exclusion and forward–backward as a method of data selection and variable selection, respectively. The docking ... See full document
14
Agonist signalling properties of radiotracers used for imaging of dopamine D2/3 receptors
... mation is not only relevant when the radiopharmaceuti- cals are used to evaluate actions of novel drugs which may show biased agonism but also because β-arrestin-2 itself may be involved in the desensitization of DA re- ... See full document
6
Dopamine D1 receptor involvement in latent inhibition and overshadowing
... (Feldon & Weiner, 1991 ; Shadach et al. 2000 ; Weiner & Feldon, 1987). Further studies have shown that both the disruption and enhancement of LI by dopaminer- gic drugs is modulated by the mesolimbic DA system. ... See full document
11
Inhibition of Stat3 signaling ameliorates atrophy of the soleus muscles in mice lacking the vitamin D receptor
... upon inhibition mirrors suppression of mTOR function in the regulation of cell size [24, ...− mice, it was shown that although mouse embryonic fibroblasts (MEFs) derived from these mice were ... See full document
17
Interactions between striatal dopamine and adenosine receptors: effects of aminophylline on a pharmacological model of parkinson's disease
... GABAB receptors (Tepper et ...the effects of acetylcholine are opposed to the effects of dopamine on direct and indirect pathways by inhibiting motor ... See full document
11
Dopamine in nucleus accumbens: salience modulation in latent inhibition and overshadowing
... Latent inhibition (LI) is demonstrated when non-reinforced pre-exposure to a to-be-conditioned stimulus retards later ...systemic amphetamine both reliably abolish ...of dopamine (DA) within ... See full document
13
Co-Administration of Curcumin and Bromocriptine Nano-liposomes for Induction of Apoptosis in Lung Cancer Cells
... The liposomal curcumin prompted in vitro apoptosis of human pancreatic cells and down-regulated NF-kB machinery. The results of a study on A549/DDP multidrug-resistant human lung adenocarcinoma cells showed that curcumin ... See full document
6
Sinomenine activates astrocytic dopamine D2 receptors and alleviates neuroinflammatory injury via the CRYAB/STAT3 pathway after ischemic stroke in mice
... astrocytes in the clinical treatment. Sino has been suc- cessfully used for rheumatoid arthritis treatment for centuries in China [33]. Studies have shown that Sino reduced the LPS-induced synthesis of prostaglandin E3, ... See full document
13
Synthesis and evaluation in rats of homologous series of [18F]-labeled dopamine D2/3 receptor agonists based on the 2-aminomethylchroman scaffold as potential PET tracers
... striata. We wanted to further evaluate these radioligands in vivo and optimize their brain penetration and non- specific binding by adjusting their lipophilicity. We rea- soned that the latter goal could be achieved by ... See full document
13
A Randomized, Prospective Comparative Study to Evaluate the Efficacy and Safety of Lurasidone and Risperidone in Treatment of Schizophrenia
... of drug-drug ...adverse effects of risperidone in patients receiving quinidine have not been evaluated, but observations in a modest number of poor metabolizers given risperidone do not suggest ... See full document
119
Extrapyramidal side effects of antipsychotics are linked to their association kinetics at dopamine D2 receptors
... (see Supplementary Fig. 1). There was a very good correlation between these two values for all APDs tested (two-tailed Pearson’s correlation r 2 = 0.98, P < 0.0001) indicating the kinetic parameters were accurate. ... See full document
11
Amphetamine Conditioned Place Preference in Planarians
... major drug-abuse ...either d-amphetamine or vehicle (water) in light and then re-tested for place preference (light vs ...by amphetamine experience, such that 12 of 16 preferred the unnatural, ... See full document
6
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