[PDF] Top 20 Analysis of human immunodeficiency virus type 1 nef gene sequences present in vivo.
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Analysis of human immunodeficiency virus type 1 nef gene sequences present in vivo.
... Among our nef genes, the nucleotide sequences encoding the IR were relatively conserved data not shown and reflected the sequence variation previously described for cultured HIV-1 isolat[r] ... See full document
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Mutational analysis of human immunodeficiency virus type 1 (HIV-1) accessory genes: requirement of a site in the nef gene for HIV-1 replication in activated CD4+ T cells in vitro and in vivo.
... and virus replication is enhanced after vaccination against influenza virus or IL-2 injection into HIV-1-infected individuals (30, 42, 62), suggesting the pres- ence of a close relationship between ... See full document
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Conservation of an intact human immunodeficiency virus type 1 vif gene in vitro and in vivo.
... the analysis of the structure of vif to primary HIV-1 strains in short-term cultures and to HIV-1 sequences present in uncultured lymphocytes from HIV-1-pos- itive individuals as ... See full document
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Genetic drift can dominate short-term human immunodeficiency virus type 1 nef quasispecies evolution in vivo.
... of virus-pulsed antigen-presenting dendritic cells and CD4 T lymphocytes in vitro (75, 83) as well as by vaccination- induced T-cell activation in seropositive patients (27, 56, ...in vivo has also been ... See full document
8
Predicting the Impact of Blocking Human Immunodeficiency Virus Type 1 Nef In Vivo
... Human immunodeficiency virus type 1 (HIV-1) Nef is a multifunctional protein that confers an ability to evade killing by cytotoxic T lymphocytes (CTLs) as well as other ... See full document
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Separation of Human Immunodeficiency Virus Type 1 Replication from nef-Mediated Pathogenesis in the Human Thymus
... Human immunodeficiency virus type 1 (HIV-1) is frequently attenuated after long-term culture in ...in vivo. Analysis of attenuated HIV-1 for replication and ... See full document
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The Human Immunodeficiency Virus Type 1nef Gene Can to a Large Extent Replace Simian Immunodeficiency Virus nef In Vivo
... HIV-1 nef can functionally replace SIV nef in vivo and (ii) to establish a pathogenic Nef-SHIV model for the study of specific HIV-1 nef mutants and the evaluation of new ... See full document
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Human Endothelial Cells Enhance Human Immunodeficiency Virus Type 1 Replication in CD4+ T Cells in a Nef-Dependent Manner In Vitro and In Vivo
... support virus production may be a result of their inability to adequately stimulate resting CD4 ⫹ T cells, but it may also indicate the requirement for active EC ...9. Nef potentiates HIV-1 ... See full document
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A role for natural simian immunodeficiency virus and human immunodeficiency virus type 1 nef alleles in lymphocyte activation.
... FACS analysis revealed that 99% of 221 cells expressed CD4 and 83% expressed CD8 on their surface ...are present at low frequency in peripheral ...cell type. nef-dependent virus ... See full document
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Nef association with human immunodeficiency virus type 1 virions and cleavage by the viral protease.
... regulatory gene product of human immunodeficiency virus type 1 (HIV-1) and other primate lentiviruses which enhances virion infectivity by an unknown ...that Nef is ... See full document
6
In Vivo Pathogenesis of a Human Immunodeficiency Virus Type 1 Reporter Virus
... detect human immunodeficiency virus type 1 (HIV-1) gene expression in viable infected cells in vivo would improve our ability to investigate HIV ...HIV-1 ... See full document
7
Nef stimulates human immunodeficiency virus type 1 proviral DNA synthesis.
... including human immunodefi- ciency virus type 1 (HIV-1), are characterized by the presence of a number of accessory genes in addition to the prototypic gag, pol, and env reading frames ... See full document
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Human Immunodeficiency Virus Type 1 Nef-Mediated Downregulation of CD4 Correlates with Nef Enhancement of Viral Pathogenesis
... The nef gene products encoded by human immunodeficiency virus type 1 (HIV-1) and simian immunodefi- ciency virus type 1 (SIV-1) increase ... See full document
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Induction of AIDS in Rhesus Monkeys by a Recombinant Simian Immunodeficiency Virus Expressing nef of Human Immunodeficiency Virus Type 1
... munodeficiency virus (SIV) is one of the most widely used animal models for the study of AIDS ...A nef gene is present in all primate lentiviruses, including SIVmac and human ... See full document
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Determination of Human Immunodeficiency Virus Type 1 Subtypes in Taiwan by vpu Gene Analysis
... with Gene- Works software (IntelliGenetics, Mountain View, ...genetic analysis) analytical package (10). The sequences of following reference strains (with their subtypes, GenBank accession numbers ... See full document
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Longitudinal Analysis of Human Immunodeficiency Virus Type 1 nef/Long Terminal Repeat Sequences in a Cohort of Long-Term Survivors Infected from a Single Source
... Sequential analysis of nef/LTR sequences spanning a 4- to 10-year period demonstrated a further loss of nef sequence that differed in magnitude between subjects ...entire nef ... See full document
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Producer-cell modification of human immunodeficiency virus type 1: Nef is a virion protein.
... Type 1 human immunodeficiency viruses encoding mutated nef reading frames are 10- to 30-fold less infectious than are isogenic viruses in which the nef gene is ...causes ... See full document
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Exon 1 leader sequences downstream of U5 are important for efficient human immunodeficiency virus type 1 gene expression.
... exon 1 portion of the lsdU5 element have been reported to contain binding sites for the nuclear factors DBF1 and Sp1 and to be important for basal HIV-1 promoter activity ...the present study, ... See full document
8
Dynamic Evolution of the Human Immunodeficiency Virus Type 1 Pathogenic Factor, Nef
... B Nef during the 50 to 70 years of the protein’s existence (32, ...of Nef residues are variable to dif- ferent degrees, a fact that makes mechanistic interpretation of mutational analysis data ... See full document
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Grossly Defective nef Gene Sequences in a Human Immunodeficiency Virus Type 1-Seropositive Long-Term Nonprogressor
... proviruses present in the peripheral blood mono- nuclear cells (PBMC) were grossly defective in either the vif, vpr, vpu, or tat1 gene, while a much lower percentage of the nef genes, 2 of 24 ... See full document
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