[PDF] Top 20 Analysis of microRNA (miRNA) expression profiles reveals 11 key biomarkers associated with non small cell lung cancer

... affect expression of multiple target genes; on the other hand, a specific mRNA may be regulated by cer- tain different ...programmed cell death protein 4 (PDCD4) [34] and PTEN ...in lung ... See full document

... Background: Non-small cell lung cancer (NSCLC) is the most frequent cause of cancer deaths ...predictive biomarkers for prognosis of NSCLC patients were ... See full document

... a key regulator in embryonic development and cellular ...inner cell mass of ...gastric cancer, 5 breast cancer, 6 ovarian cancer, 7 liver cancer, 8 and lung ...Nanog ... See full document

... of miRNA let-7, miR-21, and miR-205 are ...present analysis was therefore to evaluate the expression and the prognostic role of the above mentioned miRNAs in early-stage (T1N0) NSCLC ...miR-205 ... See full document

... that small noncoding RNA molecules known as microRNAs (miRNAs) can func- tion as tumor suppressors and ...mature miRNA processing are implicated in carcinogenesis and tumor ...alter miRNA processing, ... See full document

... Abstract: Non-small lung cell carcinoma (NSCLC) is a leading lethal disease and a global health ...in cancer has attracted the attention of more and more scientists recently, yet there ... See full document

... development, cell differentiation, apoptosis and ...of miRNA expression pro- files of human tumors have reported phenotyp- ic signatures of particular cancer types [13, ...of cancer, ... See full document

... increased expression of miR-421 in NSCLC tissues and serum samples has been indicated as an independent prognostic biomarker for NSCLC ...was associated with prognosis of ...abnormal expression of ... See full document

... in cancer is increasing. In addition to western blot analysis, im- munohistochemistry has also been performed to de- tect expression of CDK5 in cancer tissue ...prostate cancer, breast ... See full document

... gene expression profile of H460 H-INV cells (versus H460 L-INV cells), using total RNA isolated from these cell subpopulations with validated differential invasiveness (Figure ...blot analysis and ... See full document

... Differences between two groups were estimat- ed using Student’s t test and the Chi-square test. Overall survival (OS) was measured up to the date of death due to any cause or, for living patients, the date of last ... See full document

... The expression of KPNA2 correlates with histology and ...novel biomarkers for distinguishing cancer from noncancerous ...negative expression or Oct4 and KPNA2 single posi- tive ...combined ... See full document

... the cancer-promoting CAF subsets, it is necessary to identify specific markers to define these subpopulations and understand their ...28 non – small cell lung cancer (NSCLC) ... See full document

... pancreatic cancer and correlated with patients’ poor prognosis ...B1 expression in patients with resected non-small-cell lung cancer stage I-IIIA, a pre- liminary report ... See full document

... a lung-specific gene that is highly expressed in the NSCLC type of lung ...for lung cancer and be able to determine micro- metastases in lymph nodes of NSCLC patients and peripheral blood [15, ... See full document

... mir-211 expression inhibited Mxa protein expression in a549 ...qrT-Pcr analysis was used to measure the expression of Mxa in 40 nsclc tissues and 40 adjacent noncancerous ...blot ... See full document

... 4709 expression in colon adenocarcinoma predicts a poor prognosis in cancer patients ...is associated with the poor overall sur- vival in patients with laryngeal squamous cell carcinoma ... See full document

... univariate analysis using Cox’s proportional hazard model showed that the following parameters cor- related significantly with OS: tumor diameter, histological grade, tumor status, nodal status, TNM staging, AP3B ... See full document

... Regulating expression of targeted genes in post-transcription period, miRNAs involve in biological signal channels and thus influence therapeutic ...NSCLC cell lines with EGFR mutation are more sensitive to ... See full document

... pancreatic cancer, miR-155-5p was upregu- lated in tumor tissues and plasma, and the expressions in tissues were associated with tumor stage and poor prognosis ...miR-155-5p expression showed ... See full document