Top PDF ANTI-INFLAMMATORY ACTIVITY OF ETHANOLIC EXTRACT OF LEAVES BRYOPHYLLUM PINNATUM LINN

ANTI-INFLAMMATORY ACTIVITY OF ETHANOLIC EXTRACT OF LEAVES BRYOPHYLLUM PINNATUM LINN

ANTI-INFLAMMATORY ACTIVITY OF ETHANOLIC EXTRACT OF LEAVES BRYOPHYLLUM PINNATUM LINN

means to sprout and phyllon means leaf. The secondary metabolites which are obtained from different parts of plant such as alkaloid, flavanoid, tannin, glycoside, phenolic compounds, which have therapeutic value. The plant are used in different pharmacological activities such as antidiabetic antihypertensive, antileishmanial, antimicrobial, analgesic, anticancer. These are also use in bleeding disorder and ulcer and diarrhea. [1] The present study was under taken to evaluate anti inflammatory activities of ethanolic leaf extract of Bryophyllum pinnatum
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Anti-Inflammatory Activity of Ethanolic Extract of Canthium dicoccum

Anti-Inflammatory Activity of Ethanolic Extract of Canthium dicoccum

Canthium dicoccum also known as nalla balusu (telugu), nallamandharam (tamil) in India belongs to the family Rubiaceae. The plant is found in deccan peninsula, maharastra southwards, and extending from bihar eastwards to assam and Meghalaya. It is an unarmed shrub, grows upto 3m tall. In India the bark is used for fever and is also applied as plasters, decoction of the root is used in diarrhea. Bark powder with sesame oil is used in rheumatic pains. Used in inflammation, during night boiled leaf extract is taken for 2 months 4 . The plant is reported to contain ursolic acid, quercetin, rutin (K Subramani 2010), 7-O-(6-O-benzoyl-β- - glucopyranosyl)-rutin, spathulenol (20.76 %), caryophyllene oxide (19.25 %), cedren-13-ol (10.62 %) and ledene oxide (5.24 %) 5 . The objective of the present research work is to study the anti- inflammatory activity of ethanolic extract of Canthium dicoccum (ECD).
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ANTI INFLAMMATORY ACTIVITY OF ETHANOLIC EXTRACT OF LUFFA ACUTANGULA

ANTI INFLAMMATORY ACTIVITY OF ETHANOLIC EXTRACT OF LUFFA ACUTANGULA

The present study investigates the anti-inflammatory activity of ethanolic extract Luffa acutangula (fruit) using carrageenan induced paw edema in wistar albino rats. The medicinal values of the Luffa acutangula has been mentioned ancient literature as useful in the treatment of disorders of inflammation. Dried fruits of Luffa acutangula were powdered and extracted with ethanol using Soxhlation method. The anti-inflammatory activity was done by carrageenan induced hind paw edema method using Plethysmometer. Indomethacin used as a standard drug. For this activity Control group receive only carrageenan, Standard group receive indomethacin (40mg/kg), induced 0.1 ml carrageenan, test group receive ethanolic Fruit extract of Luffa acutangula (500mg/kg). The result showed that ethanolic extract of Luffa acutangula fruit exhibited statistically significant (p<0.05) inhibition of paw volume at a dose of 500 mg/kg. However, maximum inhibition of paw edema was found to be in Group II 91.70% and although the inhibition of paw edema with the extract was 72.73% which is less than standard group but higher than that of control group.
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ANTI-INFLAMMATORY ACTIVITY, TOTAL FLAVONOIDS AND TANNINS CONTENT FROM THE ETHANOLIC EXTRACT OF SPILANTHES PANICULATA LEAF GROWING IN BANGLADESH

ANTI-INFLAMMATORY ACTIVITY, TOTAL FLAVONOIDS AND TANNINS CONTENT FROM THE ETHANOLIC EXTRACT OF SPILANTHES PANICULATA LEAF GROWING IN BANGLADESH

The crude ethanolic extract of the leaves of Spilanthes paniculata Wall.ex DC (Family: Asteraceae) was evaluated for its possible anti-inflammatory activity as well as total flavonoids and tannins content growing in northeast part of Bangladesh. The anti-inflammatory activity was studied using carrageenan and histamine-induced rat paw edema test at different doses (200 and 400 mg/kg body weight) of the ethanol extract. At the dose of 400 mg/kg body weight, the extract showed a significant anti-inflammatory activity both in the carrageenan and histamine-induced oedema test models in rats showing 55.63% and 56.52% reduction in the paw volume (P<0.01) comparable to that produced by the standard drug indomethacin (61.27% and 63.35%) at 4h respectively. The percentage inhibition of the oedema paw volume by the 400 mg/kg body weight of the extract was also statistically significant (P<0.05; P<0.01) compared favorably with the indomethacin treated animals at 1, 2 and 3 h in both models. The total flavonoids and tannins content were calculated as quite high in ethanolic extract (112.98 mg/g of quercetin equivalent and 187.27 mg of gallic acid equivalent respectively). Acute toxicity test showed that the plant might be safe for pharmacological uses. Therefore, the obtained results tend to suggest the acute anti-inflammatory activity as well as total flavonoids and tannins content from the ethanolic extract of the leaves of Spilanthes paniculata and thus provide the scientific basis for the traditional uses of this plant as a remedy for toothache, pain and inflammations.
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INVITRO ANTI  INFLAMMATORY ACTIVITY OF ETHANOLIC EXTRACT OF APOROSA LINDLEYANA LEAVES

INVITRO ANTI INFLAMMATORY ACTIVITY OF ETHANOLIC EXTRACT OF APOROSA LINDLEYANA LEAVES

Aporosa lindleyana is a plant belonging to the family Euphorbiaceae, grows as small middle sized tree up to 15 m height, found throughout India. In the indigenous system of medicine the plant Aporosa lindleyana leaves have been claimed to be diuretic, roots to be used in insanity, head ache, fever, diabetes, loss of semen and liver diseases. [1] Traditionally, it is widely used in the treatment of inflammation and related disorders. However there is no scientific report available on its anti-inflammatory activity. Hence, the present study was designed to investigate the anti-inflammatory activity of ethanolic extracts of Aporosa lindleyana leaves by in vitro method. The preliminary phytochemical analysis of ethanolic extract showed the presence of many biologically active phytochemicals such as flavonoids, alkaloids, phenolic compounds, saponins, steroids and tannins and these compounds might be responsible for the anti-inflammatory properties. The possible anti- inflammatory mechanism of the Aporosa lindleyana leaf extract may be through its free radical scavenging activity, its hydrogen donating ability and increase antioxidants levels. Thereby, ethanolic leaf extract of Aporosa lindleyana preventing the spread of inflammation.
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“EVALUATION OF ANTI INFLAMMATORY ACTIVITY OF ETHANOLIC EXTRACT OF CLERODENDRUM INFORTUNATUM LINN  IN RATS”

“EVALUATION OF ANTI INFLAMMATORY ACTIVITY OF ETHANOLIC EXTRACT OF CLERODENDRUM INFORTUNATUM LINN IN RATS”

Clerodendrum infortunatum Linn. (Verbenaceae) is an important and widely used medicinal plant. Though variously used in Ayurveda, Unani and Homeopathy system of medicine in case of ailments like diarrhoea, skin disorders, venereal and scrofulous complaints, wounds, post-natal complications, as antihelminthic, external applications on tumours, etc., the plant needs thorough investigation for its specific medicinal activity. This study evaluates the acute anti-inflammatory effect of the ethanolic extract of the leaves of Clerodendrum infortunatum Linn.(EECI) in experimental animals. Acute toxicity test was done following the OECD guidelines. Following the Phytochemical analysis of the plant extract for specific plant constituents, EECI (100mg/kg, 200mg/kg, and 400mg/kg body weight b.w. p.o) was evaluated for acute anti-inflammatory activity against the carrageenan induced rat paw edema and the effects compared with reference drug aspirin (300mg/kg b.w). In acute inflammation, EECI produced significant reduction (p<0.01) at 5th hr in all the doses.This may be attributed to the inhibition of prostaglandin synthesis, phospholipase A2, and TNF alpha. Clerodendrum infortunatum Linn. as a commercial source of anti-inflammatory drug should be subjected to further research.
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Antiinflammatory, Analgesic and Antipyretic Effect Of Hibiscus Rosa Sinesis Linn Flower

Antiinflammatory, Analgesic and Antipyretic Effect Of Hibiscus Rosa Sinesis Linn Flower

The present study was undertaken to investigate the anti- inflammatory, analgesic and anti-pyretic activities of ethanolic extract of the flowers of Hibiscus rosa sinesis Linn. The anti- inflammatory activity of ethanolic extract of Hibiscus rosa sinesis Linn was evaluated using carrageenin induce paw edema, cotton pellet induce granuloma and xylene induce mice ear edema. The analgesic activities were analyzed using formalin test and writhing test; pyrexia induced by brewer’s yeast in rats. The ethanolic extract of flowers of Hibiscus rosa sinesis Linn was administered orally at 125,250 and 500 mg/kg .The result showed the plant has significant anti-inflammatory, analgesic and anti-pyretic effect. The result of acute toxicity test at which maximum toxic dose was above 5 g/kg indicates that the plant extract is relatively safe in mice. The anti- inflammatory, analgesic and anti-pyretic effect of Hibiscus rosa sinesis Linn is here demonstrated validating its use in traditional medicine.
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Analgesic and Anti-Inflammatory Activities of Ethanolic Extract of Pseudarthria Viscida (L) Roots

Analgesic and Anti-Inflammatory Activities of Ethanolic Extract of Pseudarthria Viscida (L) Roots

The present study was designed to investigate the analgesic and anti-inflammatory effects of the ethanolic extract of pseudarthria viscida Linn (EEPV). Acetic acid-induced writhing and hotplate tests were used to determine analgesic effect. Anti-inflammatory activity of EEPV was demonstrated with Wistar rats using carrageenan induced edema of the hind paw of rats. It has been shown that the EEPV (200/400 mg/kg, p. o.) significantly reduced acetic acid-induced writhing response, as well as significantly increase the hot-plate pain threshold in mice. In the Carrageenan induced mouse paw edema test, the group treated with indomethacin showed the strongest inhibition of edema formation by 62.50% in the third hour after carrageenan administration, while EEPV (200/400 mg/kg) showed 42.69% and 55.76% respectively. The extract did not produce any mortality up to the dose of 2000 mg / kg. Preliminary Phytochemical screening revealed the presence of flavonoids, proteins, tannins, and phenolic compounds. The result justifies the traditional uses of Pseudarthria viscida for the treatment of fever, inflammatory and painful conditions.
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IN VIVO ANTI INFLAMMATORY EFFECT OF AQUEOUS AND ETHANOLIC EXTRACT OF SIDA RHOMBIFOLIA L  ROOT

IN VIVO ANTI INFLAMMATORY EFFECT OF AQUEOUS AND ETHANOLIC EXTRACT OF SIDA RHOMBIFOLIA L ROOT

Inflammation plays an imperative role in pathophysiology of various diseases. Sida rhombifolia L. (Malvaceae), commonly known as Atibala is traditionally used for numerous medicinal purposes in India. The present study was carried out to demonstrate the in vivo anti-inflammatory effect of aqueous and ethanolic extract of Sida rhombifolia L. root using Wistar rats by carrageenan induced acute inflammatory paw edema method. Preliminary phytochemical screening and acute toxicity test were performed for aqueous and ethanolic extracts. Both aqueous and ethanolic extracts of Sida rhombifolia L. root at the dose rate of 200, 400 and 600 mg/ kg body weight were evaluated for anti-inflammatory property. Indomethacin at the rate of 5 mg/ kg body weight was employed as reference drug. Phytochemical screening of aqueous and ethanolic extracts revealed the presence of phenolic compounds, flavonoids, tannins and glycoside. Ethanolic extract was also indicated for the presence of steroids, alkaloids and terpenes. Acute toxicity testing upto 2000 mg/ kg body weight did not show any toxicity in rats. Sida rhombifolia L. root extract produced significant (P< 0.05) and a dose dependent anti-inflammatory activity. The time dependent inhibition of oedema was observed starting from 2 hours. The ethanolic extract produced most effective inhibition of edema. Our findings revealed that Sida rhombifolia L. root extract contribute to the reduction of the inflammatory response which validates the use of the extract in traditional medicine for treating inflammatory conditions
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Research Paper In-vitro evaluation of anti-inflammatory and anti-urolithiatic activity of Cichorium intybus leaves extract

Research Paper In-vitro evaluation of anti-inflammatory and anti-urolithiatic activity of Cichorium intybus leaves extract

From the data given in Figure 1, there was a dose dependent increase in percentage protection of HRBC membrane by hydro-ethanolic extract of C. intybus leaves extract. The results showed that C. intybus leaves extract at concentration 500 μg/ml give protection to the erythrocyte. However, the percentage inhibitions of lysis shown by the extract doses were lower than that obtained for 100 μg/ml of Aspirin. As the human erythrocyte membrane resembles the lysosomal membrane the HRBC membrane stabilization has been used to study the in-vitro anti-inflammatory activity. The lysosomal contents of the neutrophils include bactericidal enzymes and proteinases, which on further extracellular release cause tissue inflammation and damage. Therefore, stabilization of the lysosomal membrane is important in limiting the inflammatory response (Leelaprakash et al., 2011).
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Anti-Inflammatory and Hepatoprotective Activities of Ethanolic Extract of Euphorbia Thymifolia Linn.

Anti-Inflammatory and Hepatoprotective Activities of Ethanolic Extract of Euphorbia Thymifolia Linn.

The study provides a pharmacological basis for the remedial usage of E. thymifolia in inflammation related disorders. Carrageenan induced edema in the hind paw (acute inflammation) and cotton pellet granuloma (chronic inflammation) are widely employed in screening the new antiinflammatory compounds [37]. These studies investigated the antiinflammatory effect of ethanolic extracts of E. thymifolia on acute and chronic phases of inflammation. The carrageenan- induced inflammatory process in the rat involves three phases: an initial, second and third phases caused by the release of histamine and serotonin; bradykinin and prostaglandins respectively [38- 39]. In the present study the anti-inflammatory activity of ethanolic extract of E. thymifolia took place at 1, 2, and 3 h after carrageenan injection, suggesting that its action mechanism may involve multiple anti-inflammatory factors and mediators [40]. This is in consistent with the generally believed thinking that herbal preparations usually have multitargets.
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Anti-Inflammatory Activity of Mimosa hamata (Willd.)

Anti-Inflammatory Activity of Mimosa hamata (Willd.)

significantly reduced infiltration of macrophages, monocytes, neutrophils and others. These results indicate that the extract may alter the action of endogenous factors that are involved in the migration of these substances to the site of inflammation. The extract showed significant P < 0.01 anti- inflammatory activity in cotton wool induced granuloma and thus found to be effective in chronic inflammatory condition, which reflected its efficacy in inhibiting the increase in the number of fibroblasts and synthesis of collagen and mucopolysaccharides during granuloma tissue formation. Chronic inflammatory conditions was induced in animals by inserting the cotton pellets subcutaneously. The results of cotton pellet granuloma method revealed that ethanolic extract of stems 400mg/kg of Mimosa hamata (Willd.) was found to decrease the weight of granuloma significantly (42.72%) than the ethanolic extract of stems of M hamata at 200mg/kg (39.92%)
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EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF ACACIA EHRENBERGIANA (SALAM) LEAVES BY IN-VIVO AND IN- VITRO MODELSIsra I Mohammad, Mazin Y Alsafi, Mohammed M. A. AL-mahdi, Tasnim O. Elsammani*, Mahmoud M. E. Mudawi DOWNLOAD/VIEW

EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF ACACIA EHRENBERGIANA (SALAM) LEAVES BY IN-VIVO AND IN- VITRO MODELSIsra I Mohammad, Mazin Y Alsafi, Mohammed M. A. AL-mahdi, Tasnim O. Elsammani*, Mahmoud M. E. Mudawi DOWNLOAD/VIEW

The anti-inflammatory activity of the ethanolic extract of leaves of Acacia ehrenbergiana observed in this study was confirmed by using an in vitro model of anti-inflammatory activity namely stabilization of H-RBC membrane test in which the maximum inhibition of heat-induced hemolysis produced by ethanolic extract of leaves of Acacia ehrenbergiana and Diclofenac sodium was 54.17% .Another confirmatory test used in this study was albumin denaturation test. However, denaturation of protein is one of the causes of inflammation. Therefore, production of autoantigens in inflammatory diseases may be due to in vivo denaturation of the protein.
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 COMPARATIVE STUDIES ON ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITIES OF ETHANOLIC EXTRACTS OF TRUE MANGROVE AND MANGROVE ASSOCIATE LOCATED IN BHATYE BEACH AREAS OF MAHARASHTRA, INDIA

 COMPARATIVE STUDIES ON ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITIES OF ETHANOLIC EXTRACTS OF TRUE MANGROVE AND MANGROVE ASSOCIATE LOCATED IN BHATYE BEACH AREAS OF MAHARASHTRA, INDIA

The present study showed that among the phytochemicals both the mangroves revealed presence of flavonoids, tannins, triterpenes, alkaloids and saponins. Antioxidant and Anti-inflammatory activity of leaves, stems, pods and fruits of ethanolic extract of Derris trifoliata and Sonneratia alba mangrove species were studied. Total flavonoid content (TFC) was found to be maximum in S.alba fruits of ethanolic extract (792.6 mg quercetin equivalent QE/g) as well as the total phenolic content (TPC) was found to be highest (630.39 mg gallic acid equivalent GAE/g). Ethanolic extract at a concentration range (20-100 μg/mL) showed antioxidant and anti-inflammatory assay where free radical and hydrogen peroxide scavenging potentials of S. alba fruits IC 50 value (62.62 and 66.73 μg/mL) was greater as compared to other extracts respectively. The reducing power of all the extract of
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EVALUATION OF ANTI INFLAMMATORY ACTIVITY OF MUSA PARADISIACA (Linn.) LEAVES EXTRACT IN RATS

EVALUATION OF ANTI INFLAMMATORY ACTIVITY OF MUSA PARADISIACA (Linn.) LEAVES EXTRACT IN RATS

Musa Paradisiaca (Linn.) The fruits are sweet, astringent, emollient, Cooling, anthelmintic, aphrodisiac, antiscorbutic, demulcent and tonic. However, there is no authentic scientific data reported regarding anti-inflammatory activity of Musa Paradisiaca (Linn.). In this context, in the present study an attempt is proposed to evaluate the anti-inflammatory activity of Musa Paradisiaca (Linn.) Linn leaves extract in rats.

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Synergistic anti inflammatory activity of ethanolic leaves extract of calotropis gigantean ns achyranthes aspera

Synergistic anti inflammatory activity of ethanolic leaves extract of calotropis gigantean ns achyranthes aspera

Young male Swiss albino rats were selected for toxicity studies. Weight of each rat was recorded. Rats were divided into two groups (each containing three) and labelled. Solution of plant leaf extract was prepared & administered orally at different doses i.e. 5, 50, 500, and 2000 mg/kg. Any type of adverse effect and death of rat were observed upto 24 hours. The acute toxicity test was performed according to the OECD 423 guidelines.

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ASSESSMENT OF ANALGESIC AND ANTIBACTERIAL ACTIVITY OF PREMNA INTEGRIFOLIA LINN  (FAMILY: VERBENACEAE) LEAVES

ASSESSMENT OF ANALGESIC AND ANTIBACTERIAL ACTIVITY OF PREMNA INTEGRIFOLIA LINN (FAMILY: VERBENACEAE) LEAVES

Premna integrifolia Linn. (Family: Verbenaceae) is a medicinal plant which is traditionally used against a number of diseases including inflammatory condition. On the scientific basis of traditional uses, the ethanolic extract of leaves of Premna integrifolia Linn. was assessed for its possible analgesic and antimicrobial activity. The analgesic activity of the sample was studied using acetic acid induced writhing model in mice. Antibacterial activity of leaves of Premna integrifolia Linn. was tested by using the disc diffusion method. In analgesic activity, the extract produced 52.17% (p<0.01) acetic acid induced writhing inhibition in mice at the dose of 500 mg/kg body weight, which is comparable to diclofenac sodium 65.21% (p<0.01) at the dose of 25 mg/kg body weight. The extract showed significant antibacterial activity against both gram positive and gram negative bacteria. All the results tend to justify the traditional uses of the plant and require further investigation to identify the chemicals responsible for these effects.
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Anti inflammatory and analgesic activity of methanolic and chloroform extract of leaves of Nyctanthus arbortristis Linn

Anti inflammatory and analgesic activity of methanolic and chloroform extract of leaves of Nyctanthus arbortristis Linn

The practice of herbal medicine dates back to the very earliest period of known human history. There is evidence of herbs having been used in the treatment of diseases and for revitalising body system in almost all ancient civilisation. Ayurveda, the Science of Life,has provided the rational basis for treatment of various ailments, Pain, inflammation and fever are very common complications in human beings.Several plants and their products are claimed and proved to posses analgesic and anti-inflammatory property. Nyctanthus Arbortritis Linn.(family- Oleacea) is an aromatic herb which grows upto10m.The leaves are dessicately opposite, ovate, crenate to subcrudate at base.Over the last decades the leaves has been used in the treatment of inflammatory, analgesic, hepatoprotective and particular emphasis on potency specified in the screening assays. Hence in the present study, the methanolic and chloroform extract of the leaves of Nyctanthus ArbortristisLinn.was examined for its anti- inflammatory and analgesic properties.
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Anti-Inflammatory Activity of Extracts and Isolated Alkaloidal Fraction From Leaves of Bryophyllum Pinnatum

Anti-Inflammatory Activity of Extracts and Isolated Alkaloidal Fraction From Leaves of Bryophyllum Pinnatum

The alkaloidal fraction and the methanolic extract may exert their effects either by modifying the lysosomal membrane in such a way that it is capable of fusing with the plasma membranes and thereby preventing the discharge of acid hydrolases or by inhibiting the release of discharge of acid hydrolase or by inhibiting the release of lysosomal enzymes (17). An important mechanism of anti-inflammatory activity has been found to be the membrane stability-modulating effect. As the development of inflammatory process is correlated with release of lysosomal enzymes, the reduction in their release confirms the therapeutic usefulness of the said fraction, and supports further work on quantitative isolation of the components from the alkaloidal fraction and further study on other components.
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EVALUATION PHARMACOLOGICAL STUDY OF BRYOPHYLLUM PINNATUM PLANT FOR ANTILITHIATIC ACTIVITY

EVALUATION PHARMACOLOGICAL STUDY OF BRYOPHYLLUM PINNATUM PLANT FOR ANTILITHIATIC ACTIVITY

The leaves of panfuti have great medicine; value and are used for medicinal purpose both, internally as well externally. The leaves possess various properties like hemostatic, refrigerant, emollient, mucilaginous, vulnerary, depurative, anti- inflammatory, disinfectant and tonic. They are useful in vitiated condition of vata and pitta, cuts and wounds, hemorrhoids, menorrhagia, discoloration of the skin, boils, sloughing ulcers, ophthalmic, burns, scalds, corn, diarrhea, dysentery, vomiting and acute inflammations 4 . Externally, the pulp of the leaves or the juice is applied to traumatic injuries to arrest the bleeding and promote the healing of wounds. The juices of its leaves contract the minute arterioles and arrest
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