[PDF] Top 20 Antitumor activity of the novel multi-kinase inhibitor EC-70124 in triple negative breast cancer

... of EC-70124 alone or in combination with various chemotherapeutics to plot the dose–response curves and for synergy studies, ...of EC-70124 at three-time points (24 h, 48 h and 72 h of ... See full document

... EGFR/HER2 inhibitor) led to a statistically non-significant decrease in the percentage of CD44 + /CD24 -/low cells, and also a significant decrease in MSFE ... See full document

... Aurora kinase A inhibitor that is currently undergoing Phase I-III clinical development ...Aurora kinase A over B in in vitro assays and 200-fold higher selectivity in the HCT116 colorectal ... See full document

... as antitumor agent. EC-8042 is a lead molecule in the quest for mithralogs with improved therapeutic window, since it is 10 times less toxic than mithramycin in vivo, while it is active both in vitro and in ... See full document

... This study demonstrates that ENMD-2076 has durable clinical activity in a subset of patients with previously treated metastatic TNBC. We observed 27.8% and 16.7% of patients achieving prolonged clinical benefit at ... See full document

... II/III breast cancer patients, Chae et al found that statin use for as little as 6 months after the initial diagnosis was inde- pendently associated with a reduced likelihood of recurrence out to ... See full document

... in cancer progression have driven efforts to understand the cellular processes controlling EMT ...signal-regulated kinase-1/2 (ERK1/2) pathway activation, which promotes cell survival and proliferation, was ... See full document

... mostly highly expressed in CXCR2-positive 4T1 cells in the present study. Results of immunofluorescence assays showed that nearly all CXCR2 cells expressed NANOG at the same time and most SOX2-positive cells also ... See full document

... Triple-negative breast cancer (TNBC) is an aggressive subset of breast carcinomas that lack expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth ... See full document

... Abstract: Triple-negative breast cancer (TNBC) is a heterogeneous disease with poorer outcomes compared to other breast cancer ...robust antitumor responses in both ... See full document

... PIM-1 kinase, encoded by the PIM-1 gene, is the most studied and important among all three members of the PIM kinase ...PIM kinase family discovered soon afterwards, PIM- 2 and PIM-3, exhibit strong ... See full document

... of breast cancer samples [37]. The molecular subtypes of these breast cancer patients were defined by IHC staining of ER, PR, and ...being negative and a score of 2 to 8 being ...= ... See full document

... Quality assessment according to REMARK guidelines was performed for all 21 included studies. The studies fulfilled, on average, 14 items (range, 10–18 items) of the guidelines. Sensitivity and sub-group analyses were ... See full document

... HER2- negative BC to receive docetaxel (100 mg/m 2 every 21 days) or docetaxel (75 mg/m 2 day 1) plus capecitabine (825 mg/m 2 twice a day days 1 to 14) or docetaxel (75 mg/m 2 day 1) plus gemcitabine (1,000 mg/m ... See full document

... two breast can- cer cell lines, MCF-7 cells (ER –positive) and MDA-MB- 231 (ER-negative), were examined using MTT ...inhibited breast cancer cell proli- feration in a dose- and time-dependent ... See full document

... of cancer such as lymphocytic leukemia and lung cancer are beginning to emerge through extensive molecular profiling studies ...to Cancer (145 ... See full document

... technology promises to unravel previously inaccessible complexities in the transcriptome, such as allele-specific expression and novel promoters and isoforms. However, datasets produced are large and complex and ... See full document

... Breast cancer is a complex disease with no single cause, affecting 1 in 9 Canadian women (CBCF, ...female breast is tightly regulated by cascades of hormones and growth ...of breast ... See full document

... cytotoxic activity of erlotinib was not altered by the adjunction of the fluorescein residue des- pite modifications of the molar mass and of the steric ef- fect of the ...cytotoxic activity of the tracer ... See full document

... As OTX015 mediates transcriptional repression by displacing BRD4 from chromatin 15, 21 , we hypothesized that PRMT5 was transcriptionally regulated by BRD4. To assess this, we analysed again the two public ChIP-Seq ... See full document