[PDF] Top 20 Artificial antigen-presenting cells expressing AFP
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Artificial antigen-presenting cells expressing AFP
... Professional antigen-presenting cells (APCs) are potent generators of tumor antigen-specific cytotoxic T lymphocytes (CTLs) for adoptive immunotherapy; however, generation of APCs is ... See full document
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Self antigen–presenting cells expressing diabetes associated autoantigens exist in both thymus and peripheral lymphoid organs
... self-antigen–presenting cells in an antigen-specific ...II–positive cells) of NOD mice is sufficient to prevent diabetes (34), and a transgenic model of myasthenia gravis shows that ... See full document
11
Enhanced presentation of MHC class Ia, Ib and class II restricted peptides encapsulated in biodegradable nanoparticles: a promising strategy for tumor immunotherapy
... involved antigen presenting cells must be able to “ cross present ” the exogenous peptides onto MHC class I molecules by either the classical proteasome and TAP-dependent pathway [42], or by an ... See full document
10
Antitumor Activity of T Cells Generated from Lymph Nodes Draining the SEA-expressing Murine B16 Melanoma and Secondarily Activated with Dendritic Cells
... effector cells for cancer immunotherapy depends largely on the immunogenicity of the tumor drained by the lymph nodes as well as the methods for secondary in vitro T cell activation and ...tumor cells, and ... See full document
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Engineered artificial antigen presenting cells facilitate direct and efficient expansion of tumor infiltrating lymphocytes
... T cells expressing the costimulatory mole- cules CD27 and CD28 (Figure 5e,f), and reduced fre- quencies of CD4+ T cells expressing FOXP3, relative to TILs cultured in IL-2 in parallel (Figure ... See full document
13
B7 H1–expressing antigen presenting cells mediate polarization of protumorigenic Th22 subsets
... Th22 cells isolated from cor- responding tissue did not produce ...Th22 cells, whereas paired tumor monocytes were selectively linked to the IL-17–expressing Th22 subsets; blocking B7-H1 by ... See full document
12
Distinct immune signatures in directly treated and distant tumors result from TLR adjuvants and focal ablation
... tumor antigen release, cross-presentation and cross-priming by the immune system after thermal ...B16 cells expressing ovalbumin (B16-OVA) at one site and a secondary B16 tumor line not ... See full document
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Antigen presenting cells expressing Fas ligand down modulate chronic inflammatory disease in Fas ligand–deficient mice
... mononuclear cells in the mar- ginal zone of the spleen (Figure ...liver cells as determined by Hoechst staining (Figure ...mononuclear cells or parenchy- mal cells in the lung and kidney (data ... See full document
10
Ex vivo expanded natural killer cells from breast cancer patients and healthy donors are highly cytotoxic against breast cancer cell lines and patient derived tumours
... feeder cells has emerged to allow for a better sustainable ex- pansion of NK cells that was not achievable with the use of cytokines ...mononuclear cells (PBMCs) or genetically modified tumour ... See full document
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Bioengineering of Artificial Antigen Presenting Cells and Lymphoid Organs
... Artificial APCs (aAPCs) are engineered platforms for T cell activation and expansion that aim to bypass the aforementioned obstacles by mimicking the interaction between DCs and T cells.[20, 35-38, 46] They ... See full document
13
Defining novel parameters for the optimal priming and expansion of minor histocompatibility antigen specific T cells in culture
... T cells at the different time points of the REP ...of antigen-specific T-cell ...T cells found both at 12 and 21 days, we determined that the REP enhanced the proportion of IFNγ-secreting ... See full document
13
The perfect personalized cancer therapy: cancer vaccines against neoantigens
... HLA-A2.1 expressing T2 cells and seven vali- dated peptides were used for each ...T cells with IL-2. The vac- cine expanded T-cells against preexisting dominant epi- topes and induced new ... See full document
10
Allergic sensitization: host-immune factors
... epithelial cells from asthmatic subjects are more sensitive to environmental triggers including cigarette smoke [11] and viruses [12] in terms of both barrier disruption and an innate defect in the release of ... See full document
9
Natural T-cell ligands that are created by genetic variants can be transferred between cells by extracellular vesicles
... transformed cells need to be transferred to surrounding APC in order to prime naive CD4 T ...of antigen transfer is well known from solid organ transplantation where presentation of donor antigens on ... See full document
11
Cancer immunotherapy: the beginning of the end of cancer?
... Cancer therapy has long depended on strategies that dir- ectly attack tumor cells to treat patients. Cancer im- munotherapy, the treatment that harnesses the patient’s immune system to fight cancer, is now ... See full document
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Ultrasound-mediated microbubble destruction: a new method in cancer immunotherapy
... vascular cells that induces a loose intercellular gap; and microbubbles inside the vasculature can produce microstreams and shock waves, thus compromising the stability of the vascular ...NK-92 cells are ... See full document
13
Specific tolerance to an acetylcholine receptor epitope induced in vitro in myasthenia gravis CD4+ lymphocytes by soluble major histocompatibility complex class II peptide complexes
... T cells have been cloned from MG patients, and in this study, we have induced long-lasting tolerance in vitro in one particular clone (PM-A1) with a known peptide epitope (alpha 144-163) and MHC class II ... See full document
10
Car Drivers and Fuel Sources: How Distinct Signaling Domains in Chimeric Antigen Receptors Reprogram T Cells
... T cells with desired ...T cells to express chimeric antigen receptors ...T cells have distinct biochemical and metabolic features that endow them with short lived effector or long lived memory ... See full document
134
Original Article RTA inhibits liver tumor growth in mice through microvesicles delivery
... and AFP promoter was used to carry the coding region of RTA in the ...in AFP positive cells; RTA expression driven by AFP promoter could only kill AFP positive cell lines and RTA ... See full document
6
An immunohistochemical study of CD83- and CD1a-positive dendritic cells in the decidua of women with recurrent spontaneous abortion
... potent antigen-presenting cells (APC) in the immune system with the unique ability to induce primary immune responses ...stem cells, migrate through the blood, and then disperse widely in ... See full document
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