[PDF] Top 20 Attenuation of influenza A virus by insertion of a foreign epitope into the neuraminidase.
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Attenuation of influenza A virus by insertion of a foreign epitope into the neuraminidase.
... 4647 Downloaded from http://jvi.asm.org/ on November 9, 2019 by guest As the initial step in generating a live attenuated influenza A vaccine, we attempted to substitute an unrelated ami[r] ... See full document
7
Enhanced replication of avian-origin H3N2 canine influenza virus in eggs, cell cultures and mice by a two-amino acid insertion in neuraminidase stalk
... Canine influenza virus (CIV) is a newly identified, highly contagious respiratory pathogen in ...(2-aa) insertion naturally occurring at the distal end of the neuraminidase (NA) stalk found in ... See full document
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Attenuation of pathogenicity of fowl plague virus by recombination with other influenza A viruses nonpathogenic for fowl: nonexculsive dependence of pathogenicity on hemagglutinin and neuraminidase of the virus.
... 54-60 Copyright © 1976 American Society for Microbiology Attenuation of Pathogenicity of Fowl Plague Virus by Recombination with Other Influenza A Viruses Nonpathogenic for Fowl: Nonexcl[r] ... See full document
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Attenuation of Influenza A Virus mRNA Levels by Promoter Mutations
... engineered influenza A/WSN/33 viruses which have viral RNA (vRNA) segments with altered base pairs in the conserved double-stranded region of their vRNA ...the neuraminidase (NA) by using a reverse genetics ... See full document
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Balanced Hemagglutinin and Neuraminidase Activities Are Critical for Efficient Replication of Influenza A Virus
... stalk insertion) possesses substantially lower receptor-binding activity than do the other adapted vi- ruses (Table ...the virus binding affinity to sialylglycopolymers (Table ... See full document
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Antibody Epitopes on the Neuraminidase of a Recent H3N2 Influenza Virus (A/Memphis/31/98)
... Structure determination of antibody-antigen complexes by X-ray crystallography remains the only definitive way to learn how an antibody recognizes and binds to the surface of a foreign protein and thus to define ... See full document
7
The Influenza Virus Neuraminidase Protein Transmembrane and Head Domains Have Coevolved
... pN1-TMD⌬A virus recovered at 33°C was propagated at 37°C in an attempt to gener- ate rescue ...infectious virus was followed over 3 days at 37°C ...the virus recovered at day 3, mixed mutational ... See full document
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Antiviral Susceptibility of Avian and Swine Influenza Virus of the N1 Neuraminidase Subtype
... Analysis of the NA sequences of the isolates that had re- duced oseltamivir susceptibility revealed a number of muta- tions outside the catalytic and framework residues. Structural analysis suggests that these mutations ... See full document
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Amino Acid Residues Contributing to the Substrate Specificity of the Influenza A Virus Neuraminidase
... human virus N2 NAs was observed with ...human virus N2 NA acquired specificity for NeuAc␣2-6Gal, with activities for NeuAc␣2-6Gal and NeuAc␣2-3Gal becoming approximately equal, by ... See full document
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A Mutant Influenza Virus That Uses an N1 Neuraminidase as the Receptor-Binding Protein
... of virus containing the BindMut HA due to its presumed lack of receptor-binding ...a virus with the BindMut HA that grew to moderate titers in tissue ...isolated virus contained the BindMut HA and ... See full document
10
Structure of Influenza Virus N7: the Last Piece of the Neuraminidase “Jigsaw” Puzzle
... of influenza A virus neuraminidase (NA), N1 to ...addition, influenza B virus also contains NA, and there are two influenza virus NA-like molecules, N10 and N11, which ... See full document
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Influenza virus neuraminidase activates latent transforming growth factor beta.
... Influenza virus directly activates latent TGF- b ...to influenza virus infection was unexpected, since TGF- b is secreted by cells only as a biologically inactive molecule, which very few ... See full document
6
Biological and Protective Properties of Immune Sera Directed to the Influenza Virus Neuraminidase
... pseudotype virus was propagated and titrated on MDCK ...serial virus dilutions and incubated with MEM containing ...5.5). Virus titers were calculated and expressed as PFU per ... See full document
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Neuraminidase-Inhibiting Antibody Titers Correlate with Protection from Heterologous Influenza Virus Strains of the Same Neuraminidase Subtype
... FIG 1 Generation and characterization of influenza antigen-expressing VSV replicons. (A) Phylogenetic relationship of influenza A virus NA genes included in this study. Amino acid sequences were aligned using ... See full document
15
MicroRNA-Based Attenuation of Influenza Virus across Susceptible Hosts
... Previous studies using miRNA-mediated control of IAV have relied on exploiting natural disparities in miRNA expression patterns. However, these miRNAs are rare, making it difficult to control IAV replication in every ... See full document
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Mouse Saliva Inhibits Transit of Influenza Virus to the Lower Respiratory Tract by Efficiently Blocking Influenza Virus Neuraminidase Activity
... of virus were recovered from the nasal tissue of all the mice ...Udorn virus grew to high titers in the lungs of all the mice, PR8 virus FIG 1 Neutralization of hybrid viruses by untreated and ... See full document
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Novel antiviral activity of neuraminidase inhibitors against an avian influenza a virus
... inhibited the formation of spherical virus particles (i.e., physical particles). On the other hand, when H3/Osaka- infected cells were incubated with GS4071, many aggre- gated particles were observed on the cell ... See full document
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Effect of Antibody to Neuraminidase on the Maturation and Hemagglutinating Activity of an Influenza A2 Virus
... However, in the course of control experiments in a study on the effect of this serum on release of virus from infected cells, we observed a marked and reproducible drop in HA titer when [r] ... See full document
7
Characterization of a temperature-sensitive influenza B virus mutant defective in neuraminidase.
... ts5 and wildtype virus ts' grown in MDCK cells at 320C were purified by sucrose gradient centrifugation and subjected to SDS-10% PAGE At the nonpermissive temperature, ts5 showed neither[r] ... See full document
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Mutations in the cytoplasmic tail of influenza A virus neuraminidase affect incorporation into virions.
... Transfectant virus was obtained with all cytoplasmic tail mutants generated by site-directed mutagenesis of the influenza A virus tail, except for the mutant resulting from substitution [r] ... See full document
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