[PDF] Top 20 Attenuation of Influenza A Virus mRNA Levels by Promoter Mutations
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Attenuation of Influenza A Virus mRNA Levels by Promoter Mutations
... transfectant virus with a single ...of mutations in the two other single-mutant transfectants was more difficult since they were ...single mutations, at least those with mutations at positions ... See full document
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Influenza A Virus Attenuation by Codon Deoptimization of the NS Gene for Vaccine Development
... PR8 virus NS. Codon deoptimization of the influenza virus NS gene should result in lower levels of NS1 and NEP protein expression, which would likely attenuate the virus so that it ... See full document
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Mutations at Alternative 5′ Splice Sites of M1 mRNA Negatively Affect Influenza A Virus Viability and Growth Rate
... M2 mRNA 5 ⬘ ss occurs late in infection, when alternative splicing occurring at mRNA3 5 ⬘ ss is blocked by the binding of the viral polymerase complex at the first 11 or 12 nucleotides of the 5 ⬘ end of M1 ... See full document
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Effects of mutations in the effector domain of influenza A virus NS1 protein
... 7 mRNA(s) into the cellular NXF1 export pathway, by forming a ter- nary complex between NS1, NXF1 and the mRNA that requires both the NS1 effector domain and a functional RNA-binding domain ...point ... See full document
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Mutations in Influenza Virus M1 CCHH, the Putative Zinc Finger Motif, Cause Attenuation in Mice and Protect Mice against Lethal Influenza Virus Infection
... by influenza A virus-infected epithelial cells, monocytes/macrophages, and spleen cells (5, 29, 39, 52, 54, 70) and function as antiviral ...the levels of IFN- ␣ , tumor necrosis factor (TNF), IL-1 ␣ ... See full document
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MicroRNA-Based Attenuation of Influenza Virus across Susceptible Hosts
... differential levels of attenuation (12, ...of attenuation associated with miRNA targeting of each individual IAV gene segment has never been ...greatest attenuation by ...targeted virus ... See full document
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Mutations in the NS1 Protein of Swine Influenza Virus Impair Anti-Interferon Activity and Confer Attenuation in Pigs
... mouse-adapted influenza virus strains, the length of the NS1 protein has been shown to be correlated with atten- uation of replication in vitro and in mice (12, 49, ...Sw/TX/98 virus, the degree of ... See full document
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Initiation, Elongation, and Realignment during Influenza Virus mRNA Synthesis
... vRNA promoter to A (2C ¡ A) in order to disrupt G-C base pairing between the AG primer and ...wild-type promoter, nucleoside triphosphates (NTPs), and the ...vRNA promoter to A (1U ¡ A) and incubated ... See full document
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Polyuridylated mRNA Synthesized by a Recombinant Influenza Virus Is Defective in Nuclear Export
... of influenza virus vRNA is required for polymerase slippage and, conse- quently, for the synthesis of a homopolymeric tail ...poly(U)-tailed mRNA both in vitro and in vivo. To test whether a ... See full document
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Evidence that the matrix protein of influenza C virus is coded for by a spliced mRNA.
... Although an open reading frame in RNA segment 6 of influenza C/JJ/50 virus could potentially code for a protein of 374 amino acids, a splicing event results in an mRNA coding for a 242-a[r] ... See full document
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Identification of Novel Influenza A Virus Proteins Translated from PA mRNA
... FIG 6 Functions of N-truncated PAs. (A) Polymerase activities of N-trun- cated PAs. 293 cells were transfected with expression plasmids encoding PB2, PB1, and NP and a vRNA replicon possessing a firefly luciferase gene, ... See full document
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Mutational analysis of the promoter required for influenza virus virion RNA synthesis.
... 4331 Downloaded from http://jvi.asm.org/ on November 9, 2019 by guest An in vitro RNA synthesis system was established in which the influenza virus virion minus-sense RNA was made from t[r] ... See full document
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Identification of Stabilizing Mutations in an H5 Hemagglutinin Influenza Virus Protein
... H5HA-N224K⫹Q226L/CA04 virus (which possesses mutations that confer binding to human-type receptors) displayed even lower heat stability, as described previously ...the mutations isolated here ... See full document
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Mutations in the Influenza A Virus M1 Protein Enhance Virus Budding To Complement Lethal Mutations in the M2 Cytoplasmic Tail
... suppressor mutations for ...influenza virus M2 protein was found to abolish infectious virus production and reduce virus particle assembly ...revertant virus which contained a ... See full document
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Telomerase promoter mutations in human immunodeficiency virus related conjunctiva neoplasia
... TERT promoter region amplified with hTERT-F and hTERT-R primer set encompassed four SNPs and their allele frequencies have been evaluated in conjunc- tiva cases and ... See full document
7
Attenuating Mutations of the Matrix Gene of Influenza A/WSN/33 Virus
... of influenza A virus consists of eight distinct segments of negative-sense RNA coding for at least 10 viral ...spliced mRNA derived from the seventh gene segment (9, 17, ... See full document
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The RNA Polymerase of Influenza A Virus Is Stabilized by Interaction with Its Viral RNA Promoter
... Influenza virus vRNA promoter in a corkscrew configura- tion is needed to protect the RNA polymerase from heat inac- ...synthesized influenza virus vRNA sequences and ...enza ... See full document
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H7N9 influenza virus neutralizing antibodies that possess few somatic mutations
... as human H3N2 viruses that currently circulate in humans. How- ever, H7N9 and H3N2 viruses are members of different viral clades; therefore, most of the human population is likely immunologically naive to H7 subtype ... See full document
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Mutations in the cytoplasmic tail of influenza A virus neuraminidase affect incorporation into virions.
... Transfectant virus was obtained with all cytoplasmic tail mutants generated by site-directed mutagenesis of the influenza A virus tail, except for the mutant resulting from substitution [r] ... See full document
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Electrochemical Microarray as a Rapid Tool for Identification of Mutations in Influenza Virus Genes
... Figure 1. Scheme of different steps for ElectroSense CombiMatrix: Pre-hybridization (preparation of the chip to be hybridized), hybridization and post-hybridization (incubated chip in hybridization oven with rotation and ... See full document
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