[PDF] Top 20 Autopsy analyses in acute exacerbation of idiopathic pulmonary fibrosis

... interstitial fibrosis or prom- inent alveolar type II cell proliferation ...involving acute hemorrhage in the alveoli and airways as well as the presence of macrophages ... See full document

... for acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) have been updated by an international working ...any acute, clinically significant respiratory deterioration ... See full document

... Purpose: Acute exacerbation (AE) is an important outcome of idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia ... See full document

... AE-IPF: Acute exacerbation of idiopathic pulmonary fibrosis; ARDS: Acute respiratory distress syndrome; DIC: Disseminated intravascular coagulation; HMGB1: High mobility group ... See full document

... Treatment with nintedanib for acute exacerbation of idiopathic pulmonary fibrosis.. Bräunlich J, Beyer D, Mai D, et al[r] ... See full document

... mechanisms underlying this phenomenon are unknown. Oishi et al. reported that PMX-fiber removed profibro- tic cytokines such as fibroblast growth factor (FGF), platelet-derived growth factor (PDGF), and transform- ing ... See full document

... The typical pathological feature of AE-IPF is the presence of diffuse alveolar damage (DAD) superimposed on the usual interstitial pneumonia (UIP) pattern [4]. The term DAD was proposed by Katzenstein et al. [5] to ... See full document

... baseline pulmonary function data prior to AE were not ...of acute exacerbation of interstitial pneumonia from other hospital or had no diagnosis of interstitial pneumonia before ...without ... See full document

... sidered acute respiratory worsenings for the purposes of the current ...possible acute exacerbation events were pre-specified as serious acute events and study sites were asked to collect de- ... See full document

... All statistical analyses were performed using JMP software package V.13 (SAS, Cary, North Carolina, USA). Contin- uous variables were compared using unpaired t-test and Mann–Whitney U test. Categorical variables ... See full document

... 96-well miRNA expression profiles were used for 3 AE- IPF, 3 Stable-IPF(S-IPF) and 3 normal controls (NC). The array was designed according to miScript miRNA PCR Array (MIHS-117Z, Qiagen) including 84 human ... See full document

... and pulmonary fibrosis in individuals is being increasingly recognized ...“combined pulmonary fibrosis and emphysema (CPFE),” which is characterized by a heavy smoking history, exer- cise ... See full document

... baseline pulmonary function, respiratory parameters, hematologic data, serum markers, and BAL fluid findings were com- pared between patients who experienced an AE during the study period and those who did ... See full document

... of acute worsening (stars) (line B). Where the cause of the acute deterioration cannot be identified, the deterioration is termed an acute exacerbation of ...in idiopathic ... See full document

... IPF: Idiopathic Pulmonary Fibrosis; COPD: Chronic obstructive pulmonary disease; AE: Acute exacerbation; CPFE: Combined pulmonary fibrosis and emphysema; UIP: Usual ... See full document

... ABSTRACT Acute exacerbation of interstitial lung disease (ILD) is associated with a poor prognosis and high ...documented acute exacerbation in idiopathic pulmonary ... See full document

... disease exacerbation, as hypothesized previously [22] or simply that the intervals at which control measure- ments of lung function were scheduled were too ...as pulmonary hypertension associated with IPF ... See full document

... : Acute exacerbation of Chronic obstructive Pulmonary disease (AECOPD) is defined as a sustained worsening of the patient’s condition ,from the stable state in the patient’s baseline dyspnoea and ... See full document

... In this study we found clear discrepancies in both taxonomic composition and beta-diversity between ISS and SSS collected concurrently from COPD patients in the stable state and during exacerbations when comparing ... See full document

... Apart from the many studies performed in humans, research is still ingoing. To-date, there are at least two listed trials, aiming to support the data generated so far. The first study, which is already recruiting ... See full document