[PDF] Top 20 <p>Avatrombopag for the treatment of immune thrombocytopenia and thrombocytopenia of chronic liver disease</p>

... on avatrombopag (who had a peak platelet count below 100×10 9 /L); by comparison, there was one patient on the placebo arm who developed pulmonary embolism and another that had an acute myocardial ...on ... See full document

... Primary immune thrombocytopenia (ITP) is an autoimmune disorder characterized by isolated ...of thrombocytopenia will extend beyond 12 months consistent with a diagnosis of chronic ...in ... See full document

... Immune thrombocytopenia (ITP) is an autoim- mune disease characterized by immune-medi- ated platelet destruction and reduced platelet production caused by antiplatelet autoantibod- ies, ... See full document

... with immune thrombocytopenia ...on treatment) occurred in 43% of patients on fostamatinib ...ITP treatment option that targets an important mechanism of ITP ... See full document

... with chronic ITP (ITP > 12 months), who have had an insuf fi cient response to previous ITP ...the treatment of chronic ITP in adults who have had an insuf fi cient response to prior ... See full document

... each treatment class: CS, IVIg, anti-D, RT, and SPL and an ‘Other’ inter- vention ...Each treatment module included questions on treatment effects and associated bother for each treatment ... See full document

... of disease varies signi fi cantly between pediatric and adult ...develop chronic disease. 10 Because the natural history of disease favors remission and the likelihood of signi fi cant bleeding ... See full document

... platelets was signifi cantly faster for patients receiving IVIg compared to anti-D. The hemoglobin fell to less than 10 g/dL in 24% of the patients receiving anti-D. The authors were unable to recommend anti-D as initial ... See full document

... At baseline, demographics, Eastern Cooperative Oncology Group (ECOG) performance status, occurrence of bleeding at diagnosis, bleeding degree by World Health Organization score, 18 and anatomic sites of bleeding (skin, ... See full document

... mediate immune responses associated with cytotoxicity and local inflammation and are involved in cellular im- munity and the formation of delayed-type hypersensitivity ...ITP. Treatment with a large dose of ... See full document

... 3. Ballem PJ, Segal GM, Stratton JR, Gernsheimer T, Adamson JW, Slichter SJ. Mechanisms of thrombocytopenia in chronic autoimmune thrombocytopenic purpura. Evidence of both impaired platelet produc- tion ... See full document

... as chronic infections, including Helicobacter pylori and human immunodeficiency virus (HIV), or autoimmune diseases such as systemic lupus erythematosus or rheumatoid ...[12–15]. Treatment of or the natural ... See full document

... A 42-year-old man visited Dr. Prabhakar Kore hospital and MRC, Belgaum. He had complaints of Fever for two days and rashes on both the forearms and also complaints of passing of black colored stools. Fever was ... See full document

... for treatment of chronic ...going treatment with romiplostim, with the majority of patients maintained on romiplostim on a once a week schedule, and with some patients being able to reduce the dose ... See full document

... to treatment with romiplostim were assumed to have a duration of treatment based on the empirical data from the eltrombopag ...on treatment duration would improve the robustness of the ... See full document

... Abstract: Thrombocytopenia is the most common hematological abnormality encountered in patients with chronic liver disease ...advanced disease and poor prognosis, it frequently prevents ... See full document

... considering treatment of ...effective treatment for ITP ...the treatment course was suggested by some studies to induce more durable remissions ... See full document

... To our knowledge, this is the most comprehensive cost- consequence model comparing EPAG with ROMI in adults with cITP who have had an insufficient response to cortico- steroids, immunoglobulins, or splenectomy. This is ... See full document

... demonstrated thrombocytopenia of 2000/μL, with no other ...IVIG treatment, the child was further treated with oral prednisone and later with pulse methylprednisolone therapy, with complete resolution of the ... See full document

... “Immune thrombocytopenia” (ITP) is an autoimmune disorder that leads to peripheral destruction, as well as a decreased production of ...for thrombocytopenia in adults with ...treat ... See full document