[PDF] Top 20 On the Average Coefficient of Dominance of Deleterious Spontaneous Mutations
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On the Average Coefficient of Dominance of Deleterious Spontaneous Mutations
... Ohnishi using Equation 1. As stated above, averaging estimates from different generations gives greater weight to early mutations. Therefore, here we refer to the estimates at generation 40, which are the most ... See full document
11
The Effect of Antagonistic Pleiotropy on the Estimation of the Average Coefficient of Dominance of Deleterious Mutations
... the average coefficient of dominance of deleterious mutations from segregating ...the deleterious mutations affecting a given studied fitness component are assumed to have ... See full document
16
Analysis of the Estimators of the Average Coefficient of Dominance of Deleterious Mutations
... be deleterious mutations (Equation ...between deleterious mutation, Garcı´a-Dorado et ...true average a few loci with overdominant effects for fitness. How- dominance is ... See full document
18
Dominance and Overdominance of Mildly Deleterious Induced Mutations for Fitness Traits in Caenorhabditis elegans
... Thus, the results from our reassay are consistent with tions are partially recessive on average. In a series of the hypothesis that at least 2 of the 19 lines originally mutation-accumulation experiments on D. ... See full document
12
Dominance of Mutations Affecting Viability in Drosophila melanogaster
... been dominance (negative h ) when MA line chromosomes no tests of whether TE insertions show greater average were made heterozygous against a chromosome from a dominance in their fitness effects than ... See full document
8
Influence of Dominance, Leptokurtosis and Pleiotropy of Deleterious Mutations on Quantitative Genetic Variation at Mutation-Selection Balance
... Dominance coefficients of new mutations are as- (Falconer and Mackay 1996), respectively. The sumed to be either constant or variable across loci. Anal- strength of apparent stabilizing selection can be ... See full document
14
The evolution of recombination rates caused by recurrent deleterious mutations
... of mutations on one particular fitness trait relates to the total fitness effect of each mutation in natural ...an average 11%, whereas Temin (1966) found that similarly induced lethals reduced heterozygous ... See full document
120
Rates of Spontaneous Mutation
... G e Effective genome size (portion in which most mutations are deleterious) h Dominance coefficient associated with a typical detrimental mutation D M Rate of decline per generation of t[r] ... See full document
20
Joint Evolution of Dispersal and Inbreeding Load
... mildly deleterious mutations (s ¼ ...recessive mutations also induced more heterosis, owing to their higher equi- librium frequencies and number of lethal equivalents F igure ...have dominance ... See full document
13
The genetic structure of natural populations of Drosophila melanogaster. XXIV. Effects of hybrid dysgenesis on the components of genetic variance of variability.
... Estimation of the average degree of dominance for mildly deleterious mutations: One hundred and sixty-four crosses for the Native background and 157 crosses for the Forei[r] ... See full document
8
Inbreeding Load, Average Dominance and the Mutation Rate for Mildly Deleterious Alleles in Mimulus guttatus
... mildly deleterious alleles rather than recessive lethals or ...major deleterious alleles but was ineffective in purging alleles with minor fitness effects and did not appreciably diminish overall levels of ... See full document
14
Hypermutability in Asexuals: Investigating the Effects of Deleterious Mutations
... mutations can indeed affect the spread of a neutral lineage. In other simulations (not shown) I have shown that the spread of an isolated beneficial mutation in a population can be similarly inhibited, and ... See full document
98
The Effects of Deleterious Mutations on Evolution at Linked Sites
... Interest among population geneticists in the effects of selection on variability and evolution at linked sites increased in the late 1980s and early 1990s, in response to the finding that putatively neutral silent DNA ... See full document
18
Assessment of the Ecological Footprint of an Average Household in the Vladimir Region
... region’s average household was formed with regard to all 80 consumption items in the EF ...the average prices for goods and services (The Federal State Statistics Service for the Vladimir region, 2011b), ... See full document
10
The effect of deleterious mutations on neutral molecular variation.
... Approximate formulas are derived for the reduction below classical neutral values resulting from such background selection against deleterious mutations, for the mean times [r] ... See full document
15
Heterosis for Viability, Fecundity, and Male Fertility in Drosophila melanogaster: Comparison of Mutational and Standing Variation
... The contrast between the results for female fecundity and those for male fertility suggests that mutations affecting different fitness traits may differ in their average dominance proper[r] ... See full document
18
Limited Dispersal, Deleterious Mutations and the Evolution of Sex
... if there is one-way mutation to deleterious alleles, and if there is no movement of genetic material between sites as a result of colonization, migration or sexual [r] ... See full document
8
Accumulation of Deleterious Mutations During Bacterial Range Expansions
... adaptive mutations in some HMR lines in the early phases of the ...some mutations could have potentially allowed some strains to preferen- tially occupy the wave front and thus access fresh ...of ... See full document
16
Germline <em>BRCA1</em> and <em>BRCA2</em> deleterious mutations and variants of unknown clinical significance associated with breast/ovarian cancer: a report from North India
... Cases tested negative for BRCA1/BRCA2 mutations were further investigated for possible large genomic rearrange- ments by MLPA assay. SALSA MLPA P002:BRCA1 and P090:BRCA2 kits (MRC Holland, Amsterdam, the ... See full document
12
A ruby in the rubbish: beneficial mutations, deleterious mutations and the evolution of sex.
... This expression embodies the assumptions of the model, since the in- finite population and infinite number of loci assump- tions imply that deleterious mutations will a[r] ... See full document
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