[PDF] Top 20 Basal-like breast cancer: molecular profiles, clinical features and survival outcomes
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Basal-like breast cancer: molecular profiles, clinical features and survival outcomes
... The Differential filter [36] was employed to select probes exhibiting distinct expression levels between tumours and controls. The underlying assumption is that probes truly correlated with breast cancer ... See full document
17
Association between mammographic density and basal like and luminal A breast cancer subtypes
... the molecular profiles of breast cancers have indicated that breast tumors can be classified into five etiologically and prognostically relevant subtypes on the basis of gene expression ... See full document
10
Identification and evaluation of network modules for the prognosis of basal-like breast cancer
... BLBC molecular subtype, henceforth referred to as the ‘training’ ...free survival (DFS) as the clinical endpoint for this analysis, although in some cases distant metastasis free survival was ... See full document
12
CD44 enhances invasion of basal like breast cancer cells by upregulating serine protease and collagen degrading enzymatic expression and activity
... the molecular sub- types, elevated levels of HA in tumor stroma were shown to correlate with poorly differentiated tumors, auxiliary lymph node status, and short overall survival in breast ... See full document
19
Splicing imbalances in basal-like breast cancer underpin perturbation of cell surface and oncogenic pathways and are associated with patients' survival.
... level survival analyses we could disentangle associations between gene expression and exon splicing levels with clinical ...with basal-like tumour patients’ survival, whilst the same ... See full document
34
Original Article HER2 status in molecular apocrine breast cancer: associations with clinical, pathological, and molecular features
... triple-negative breast cancer (TNBC) is defined by immunohistochemical profile of ne- gative expression for hormone receptors (ER, PR) and HER2 in paraffin-embedded tissue ...distinguishing ... See full document
10
PD-1 and PD-L1 correlated gene expression profiles and their association with clinical outcomes of breast cancer
... of breast cancer determine the immune activation of tumor microenvironment and is related with clinical outcome of ...index, basal- like subtypes, and distant metastasis of ... See full document
9
Metabolic biomarkers for response to PI3K inhibition in basal like breast cancer
... studies, cancer aggressiveness has gener- ally been assumed to be associated with high PCho con- centration, and response to therapy assumed to be reflected in decreased concentrations of this metabolite ...in ... See full document
18
Metaplastic carcinoma of the breast: an immunohistochemical study
... of breast cancer: luminal, basal-like, normal breast- like and HER2 positive ...behavior, clinical outcome, histologic grades and response to ...classify breast ... See full document
10
Intrinsic molecular signature of breast cancer in a population based cohort of 412 patients
... the basal-like and normal-like tumors ...the basal- like tumors had even fewer ER-positive tumors and more high- grade tumors, they had better relapse-free survival than the ... See full document
9
A clinically relevant gene signature in triple negative and basal like breast cancer
... main molecular subtypes within the data and then assess the prognostic differences between the molecular ...the molecular structure based prognostic predictions in validation (Additional file 1, ... See full document
12
The Met oncogene and basal like breast cancer: another culprit to watch out for?
... the basal-like breast cancers (BLBCs) are those that have the worst clinical outcome: they represent 15 to 20% of human breast cancer and are characterized by an aggressive ... See full document
10
CD8+ lymphocyte infiltration is an independent favorable prognostic indicator in basal like breast cancer
... core basal group. Basal-like breast cancers have distinctive survival patterns, many relapses and deaths during the first 5 years after diagnosis, but fewer events after this period ... See full document
14
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... in basal-like breast cancer; although we didn’t find any significant association, but it showed that mutant p53-topoisomerase IIα co-expressed in half of ...in basal-like ... See full document
6
FREQUENCY AND DISTRIBUTION OF CYTOPLASMIC AND NUCLEAR P63 IN RECOGNIZING THE BASAL LIKE AND NON BASAL LIKE TYPES OF BREAST CANCER BASED ON AGE
... the basal-like type still has not been found in metaplastic ...of basal-like and non-basal-like types was not yet ...to basal-like and non-basal-like ... See full document
5
Annexin A1 expression in a pooled breast cancer series: association with tumor subtypes and prognosis
... worse survival in patients with high risk of recurrence in an age-dependent manner, with worst out- come in premenopausal patients, especially in the group that received anthracycline-based adjuvant chemother- ... See full document
11
Targeted Pten deletion plus p53 R270H mutation in mouse mammary epithelium induces aggressive claudin low and basal like breast cancer
... p53-mutant-driven breast cancer are there- fore of great ...on cancer stem cells [28], we suspect that the effects of miconazole and thiethylperazine are not specific because multiple other ... See full document
16
Metformin increases survival in hormone receptor positive, HER2 positive breast cancer patients with diabetes
... fore breast cancer diagnosis was not ...on breast cancer surgery and the hbA1C level, which stands for the severity of diabetes for diabetic patients, but there were no significant difference ... See full document
14
Survival Outcomes of Breast Cancer in Ghana: An Analysis of Clinicopathological Features
... Breast cancer is a malignant tumour in the glandular tissues of the ...threatening cancer, and the second most common cause of cancer-related deaths of women in the Western world ...Ghana, ... See full document
11
MFAP5 promotes basal-like breast cancer progression by activating the EMT program
... dominant pattern of intrinsic gene expression in BLBC [12]. Some studies have implicated that the development and progression of BLBC involves several signaling path- ways such as TGF-β [14], MEK/PI3K [23, 30], integrin ... See full document
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