[PDF] Top 20 DNA Binding and Modulation of Gene Expression by the Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus
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DNA Binding and Modulation of Gene Expression by the Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus
... Kaposi’s sarcoma-associated herpesvirus (KSHV) is associated with Kaposi’s sarcoma, primary effusion lymphoma, and multicentric Castleman’s ...The latency-associated ... See full document
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Modulation of Cellular and Viral Gene Expression by the Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus
... Kaposi’s sarcoma-associated herpesvirus (KSHV), also called human herpesvirus 8 (HHV-8), is the likely etiological agent of Kaposi’s sarcoma and primary effusion ...Viral gene ... See full document
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Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus Recruits Uracil DNA Glycosylase 2 at the Terminal Repeats and Is Important for Latent Persistence of the Virus
... target DNA, suggest- ing that LANA by its own does not have any UNG activity ...plate DNA with the immunoprecipitate from LANA-myc–HA- UNG2-transfected cells blocked reamplification, suggesting the presence ... See full document
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Chromosome Binding Site of Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus Is Essential for Persistent Episome Maintenance and Is Functionally Replaced by Histone H1
... ⌬N-LANA. Expression plasmids encoding ⌬N-LANA and wild-type LANA1 were transfected into a hu- man B-cell line (BJAB) together with the hygromycin resis- tance gene, and the cells were seeded in 96-well ... See full document
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Modulation of Host Gene Expression by the K15 Protein of Kaposi's Sarcoma-Associated Herpesvirus
... its expression increased upon induction of the lytic viral life cycle with sodium ...K15 expression, the addition of both compounds (so- dium butyrate and baculovirus RTA/ORF50) was most effec- tive in the ... See full document
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Kaposi's Sarcoma-Associated Herpesvirus-Encoded Latency-Associated Nuclear Antigen Reduces Interleukin-8 Expression in Endothelial Cells and Impairs Neutrophil Chemotaxis by Degrading Nuclear p65
... IL-8 expression in endothelial cell ...target gene IL-8, which was upregulated by TNF- ␣ induction in control TIVE cells (about 33-fold), was found to be silenced in LANA-1-expressing TIVE cells (about ... See full document
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Regulation of the Interaction between Glycogen Synthase Kinase 3 and the Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen
... Kaposi’s sarcoma-associated herpesvirus (KSHV)-encoded latency-associated nuclear antigen (LANA) protein stabilizes  -catenin by the novel mechanism of binding to ... See full document
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Latency-Associated Nuclear Antigen (LANA) of Kaposi's Sarcoma-Associated Herpesvirus Interacts with Origin Recognition Complexes at the LANA Binding Sequence within the Terminal Repeats
... glutathione S-transferase (GST) fusion pro- teins (approximately 10 g for each reaction), LANA N (amino acids 1 to 340) and LANA C (amino acids 940 to 1162) expressed in Escherichia coli were used for in vitro ... See full document
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Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Interacts with Bromodomain Protein Brd4 on Host Mitotic Chromosomes
... mosomes to ensure maintenance of viral episomes in dividing cells (1, 2, 10, 49, 50, 57). This tethering mechanism involves concomitant interaction of LANA with both the viral episomes and the host metaphase chromosomes. ... See full document
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Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus (KSHV) Upregulates Survivin Expression in KSHV-Associated B-Lymphoma Cells and Contributes to Their Proliferation
... the expression of a vast number of genes important for survival as part of its generalized transcrip- tion ...Survivin gene expression is essential and evolu- tionarily conserved during late-stage ... See full document
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Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Interacts with Multifunctional Angiogenin To Utilize Its Antiapoptotic Functions
... Kaposi’s sarcoma-associated herpesvirus (KSHV) is etiologically associated with the angioproliferative Kaposi’s sarcoma ...the expression of latency-associated ... See full document
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Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Induces Expression of the Helix-Loop-Helix Protein Id-1 in Human Endothelial Cells
... protein expression in KS, normal human microvascu- lar ECs were infected with KSHV using the method described by Ciufo et ...Id-1 expression in ECs and KSHV-infected ECs ...Id-1 expression com- pared ... See full document
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Kaposi's Sarcoma-Associated Herpesvirus (KSHV) Latency-Associated Nuclear Antigen Regulates the KSHV Epigenome by Association with the Histone Demethylase KDM3A
... histone binding motifs, such as the Tudor domain or PHD finger, in the LANA protein ...for nuclear accu- mulation of HIF-1 ␣ ...␣ binding sites ... See full document
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Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Prolongs the Life Span of Primary Human Umbilical Vein Endothelial Cells
... Kaposi’s sarcoma-associated herpesvirus (KSHV) is a mem- ber of the gammaherpesvirus subfamily, which is the group of herpesviruses known to be associated with cellular prolifera- tion and ... See full document
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Kaposi's Sarcoma-Associated Herpesvirus-Encoded Latency-Associated Nuclear Antigen Modulates K1 Expression through Its cis-Acting Elements within the Terminal Repeats
... factor binding sites were not responsible for RTA-mediated up-regulation but important in LANA- mediated ...factor binding sites within ⫺ 116 to ⫹ 76, similar to a previous report ...factor binding ... See full document
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Kinetics of Kaposi’s Sarcoma-Associated Herpesvirus Gene Expression
... Herpesvirus gene expression can be classified into four distinct kinetic stages: latent, immediate early, early, and ...Kaposi’s sarcoma-associated herpesvirus (KSHV)/human ... See full document
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Modulation of Cellular CpG DNA Methylation by Kaposi's Sarcoma-Associated Herpesvirus
... of gene expression in this lymphoma, this analysis still lacks a direct connection between KSHV infection and cellular DNA methylation as we were comparing different cell ...link DNA ... See full document
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Kaposi's Sarcoma-Associated Herpesvirus Latent and Lytic Gene Expression as Revealed by DNA Arrays
... KSHV gene expression during ...KSHV gene expression ...their expression varies over all ...of expression situ- ated on the same ...of expression at levels sufficiently ... See full document
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Brd2/RING3 Interacts with a Chromatin-Binding Domain in the Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen 1 (LANA-1) That Is Required for Multiple Functions of LANA-1
... LANA expression vector as de- scribed in reference ...the DNA amplified with primers 73AC3 and 73AC4 was cloned downstream the N-termi- nal region of the dLANA-1 (aa 1 to 275) construct described in ... See full document
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Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Inhibits Major Histocompatibility Complex Class II Expression by Disrupting Enhanceosome Assembly through Binding with the Regulatory Factor X Complex
... direct DNA-binding domain but is recruited to the MHC-II promoters via interactions with the pro- teins of the MHC-II enhanceosome complex, including the pro- teins of the RFX complex ...the binding ... See full document
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