[PDF] Top 20 Binding Studies of Neuronal Nicotinic Acetylcholine Receptors Expressing Unnatural Amino Acids
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Binding Studies of Neuronal Nicotinic Acetylcholine Receptors Expressing Unnatural Amino Acids
... this binding pattern holds for both stoichio metries of the α4β2 receptor, A3B2 and ...the nicotinic pharmacophore by failing to make a functionally significant additional hydrogen bond to the backbone NH ... See full document
138
Structure Function Studies of Nicotinic Acetylcholine Receptors Using Unnatural Amino Acids and Synthetic Agonist Analogs
... 62. Frisch, M. J.; Trucks, G. W.; Schlegel, H. B.; Scuseria, G. E.; Robb, M. A.; Cheeseman, J. R.; Montgomery, J. A.; Vreven, T.; Kudin, K. N.; Burant, J. C.; Millam, J. M.; Iyengar, S. S.; Tomasi, J.; Barone, V.; ... See full document
262
Fluorescence Microscopy of Nicotinic Acetylcholine Receptors
... ligand binding domains, which may be important for interactions with agonists or molecular chaperones, but the M3-M4 loop also contains sequencing motifs important for assembly of the nAChR pentamer and ... See full document
83
Chemical-Scale Studies of the Nicotinic and Muscarinic Acetylcholine Receptors
... of amino acids in the M2 helix that forms the gate of the channel 1,3 ...ACh binding protein (AChBP) crystal structure 6 , the model suggests that during gating the β1-β2 loop of the extracellular ... See full document
153
Single-Molecule Studies of Ion Channels Expressing Unnatural Amino Acids
... a binding interaction with an allosteric effector and an intrinsic conformational change associated with the signaling ...Cys-loop receptors and to allosteric receptors in ...Cys-loop ... See full document
361
Structure-Function Studies of Nicotinic Acetylcholine Receptors Using Unnatural Amino Acids
... Chapter 3 extends studies of the point mutation near TrpB, termed the “loop B glycine.” We examine the muscle-type, α4β2, and α7 subtypes and show that the identity of this residue strongly correlates with ... See full document
20
Structure-function Studies of Nicotinic Acetylcholine Receptors Using Unnatural Amino Acids
... loop receptors, precise distance constraints were not ...our studies suggest that extending the definition further out from the interface does not significantly impact the ... See full document
157
Role of Phosphoinositides in the biology of the amyloid precursor protein
... by studies with sAPP α that show effects on cell growth in vitro and also conditional knock-in studies which show that the extracellular region of APP can rescue the lethal phenotype of APP/APLP2 double ... See full document
252
Basal acetylcholine release in leech ganglia depolarizes neurons through receptors with a nicotinic binding site
... the receptors that mediate this response: an increase in the concentration of ACh in the neuropil may not affect the somatic ...corresponding receptors in the membrane of the AP cells, which showed a ... See full document
9
Nematode nicotinic acetylcholine receptors: a single channel study in Ascaris suum and Caenorhabditis elegans
... Human studies show that anthelmintic treatment with cholinergic anthelmintics and other anthelmintics is <100% effective. Albonico et al. (Albonico et al., 2002) described the efficacy of cholinergic ... See full document
145
Site-specific incorporation of unnatural amino acids into receptors expressed in mammalian cells
... Unnatural amino acid incorporation takes advantage of nonsense suppression, a phenomenon in which a stop codon can be read by a suppressor ...natural amino acids [9, 10]. In the ... See full document
14
Chemical Scale Studies of the Nicotinic Acetylcholine Receptor: Insights from Amide to Ester Backbone Mutagenesis
... S.C.R. Unnatural amino acid mutagenesis of the GABA(A) receptor binding site residues reveals a novel cation-pi interaction between GABA and ... See full document
174
Lophotoxin insensitive nematode nicotinic acetylcholine receptors
... Caenorhabditis elegans is an organism well-suited to the study of fundamental questions in neurobiology, as its nervous system consists of only 302 cells (381 cells in males) and has been mapped in its entirety (White et ... See full document
8
Structure Function Studies of Nicotinic Acetylcholine Receptors Using Selective Agonists and Positive Allosteric Modulators
... PAM binding pockets was performed on the " 7 ...transmembrane binding region. Residues linked to PNU-120596 (Type II PAM) binding and those around the site were probed using the Type I PAM ... See full document
157
In Vivo Incorporation of Multiple Unnatural Amino Acids
... helpful with experiments and always brings up interesting conversation topics. Katie McMenimen always leant me her laptop because I was too cheap to buy one, was familiar with fun attractions in the area, and good at ... See full document
289
Nicotinic acetylcholine receptors: specific antibodies and functions in humoral immunity
... of nicotinic receptors in mito- chondria has initially been discussed in connec- tion with the neuroprotective role of ...other studies, the decrease of mito- chondria membrane potential caused by ... See full document
10
Imidacloprid actions on insect neuronal acetylcholine receptors
... Bath-application of Imidacloprid (10 µmol l −1 ) also reduced the amplitude of cEPSPs evoked by electrical stimulation of cercal nerve XI. Only partial recovery was usually observed even after a 20 min saline wash (Fig. ... See full document
8
The Development Of Intrinsically Fluorescent Unnatural Amino Acids For In Vivo Incorporation Into Proteins
... can be performed with either intrinsically fluorescent proteins or fluorescently labelled proteins. Protein conformational changes can be monitored by observation of changes in the fluorescence of a single probe or ... See full document
167
I Chemical Scale Studies of Ligand Gated Ion Channels, and II Novel Methods for Phosphonate Synthesis
... The standing group protocol for assaying amino acid-dCA esters was electrospray MS. However, prior to assay, the esters were purified by HPLC using an ammonium acetate buffered phase, and the ammonium ions ... See full document
142
Nicotinic acetylcholine receptors modulate osteoclastogenesis
... several studies have implicated nAChRs and mAChRs in regulating osteoclastogenesis; however, their effects on osteoclastogenesis have not yet been fully elucidated ...other studies have reported a ... See full document
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