[PDF] Top 20 Biological and clinical influences of <em>NPM1 </em>in acute myeloid leukemia patients with <em>DNMT3A</em> mutations

... of DNMT3A mutations should be considered as a poor-risk prognostic factor, irrespective of the NPM1 genotype as it may disturb the ...concerning DNMT3A mutations alone in AML ... See full document

... cytogenetics, DNMT3A mutation status has an impact on outcome in the presence of FLT3 and/or NPM1 ...mutant DNMT3A is associated with adverse outcomes among CN-AML patients that have ... See full document

... only DNMT3A R882 was the independent risk factor for OS and DFS of AML FLT3-ITD+/NPM1+ ...AML patients, the co-occurrence between mutations in FLT3, DNMT3A, and NPM1 was the most ... See full document

... AML patients with MGUS, by comparing CR before and after we found that while the patient ’ s M protein turned negative, the TLS-ERG fusion gene and BCOR gene mutation also ...TLS-ERG leukemia fusion protein ... See full document

... the biological insight of acute myeloid leukemia (AML) has increased in the past few years, the discovery of novel discriminative biomarkers remains of utmost value for improving outcome ... See full document

... were taken into account however, the effects of these two therapies were statistically equivalent. Patients with the DNMT3A and IDH1/2 double mutation showed no gain in EFS or OS after either HSCT or ... See full document

... of patients with sensitising EGFR-mutant NSCLC prior to ...among patients who achieve PR with EGFR- TKI can be explained by the selection model while the higher incidence of acquired T790M mutation among ... See full document

... The limitations of the study include a limited number of polymorphisms included, small sample size, and variability of pharmacokinetic parameters. The most likely cause is the difference in characteristics of patient. ... See full document

... and clinical and pathological features, such as patient age and sex, tumor location and stage, and MSI status, is listed in Table ...female patients (P = ... See full document

... consistent with previous studies. Multiple bioinformatics analysis results revealed that cell adhesion, differentiation, and proliferation may play a crucial role in TP53 mutation AML. Cell adhesion-related genes and ... See full document

... promote EM in the acute phase of critical illness [37–40], many hospitals in Japan do not have a specialized team to conduct this ...ill patients [33, ...of EM in the acute phase of ... See full document

... SPSS version 16 (Prentice Hall, Upper Saddle River, NJ, USA) was used for association analysis. Continuous variables were summarized as mean (SD). The chi-square statistics were used to compare categorical variables ... See full document

... Another susceptibility gene, G72, modulates NMDAR neurotransmission via activating D-amino acid oxidase (DAAO) to oxidize D-serine, a potent NMDAR agonist, 25 to hydroxy-pyruvate. 26 Hence, G72 expression with DAAO ... See full document

... changes, and aggression, were also prominent. In addition, four asymptomatic relatives (IV;1, III;7, IV;2, and IV;3) also agreed for the genetic test. None of these family members who were tested carried the E280K ... See full document

... pilB, hylA, ecbA, scm, fms8, efaAfm, and sgrA. The analysis showed that the prevalence of the different virulence genes in Enterococcus spp. ranged from 35.4% to 100%. pilB, fms8, efaAfm, and sgrA were the most prevalent ... See full document

... these patients had only defective alleles, including the two patients who were PM for both CYP2D6 and CYP3A5 ...cancer patients undergoing TAM treatment potentially have a risk for a low activity of ... See full document

... platelet aggregation observed with the CYP3A4*22 and PPAR-α variants in our study would be associated with altered clinical outcomes similar to those observed, in larger patient cohorts, for CYP2C19*2. In a study ... See full document

... with clinical outcomes in four countries, so the data were treated ...2,657 patients) assessed the association between iceA1 and infec- tion outcomes, but eight studies did not involve GC ...2,281 ... See full document

... A population of Russians was chosen as the comparison group, as this is the largest ethnic group in Russia. The control group was arranged according to data in the literature (we used PubMed as the main source), with ... See full document

... EGFR-mutated patients receiving EGFR-TKIs for lung adenocarcinoma were screened at Hangzhou Cancer Hospital between 2009 and ...Resistant mutations such as T790M, S768I and exon 20 insertions were ... See full document