[PDF] Top 20 Biophysical Studies of Ligand-gated Ion Channels
Has 10000 "Biophysical Studies of Ligand-gated Ion Channels" found on our website. Below are the top 20 most common "Biophysical Studies of Ligand-gated Ion Channels".
Biophysical Studies of Ligand-gated Ion Channels
... ABSTRACT This dissertation describes building a methodology for and the biophysical studies of ligand-gated ion channels (LGICs). The primary focus of the first half of this ... See full document
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Chemical-Scale Studies of Ligand-Gated Ion Channels
... of ion channels, which are large, multi-subunit proteins, is essential to understanding the biological function of these neuroreceptors and their interactions with ...different ion channels ... See full document
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Ligand-Gated Ion Channels in Sensory Neurons
... A n o th e r p a r t of th e p ro ject w as to in v e s tig a te p o ssib le m ec h an ism s by w hich N G F m ig h t a lte r th e p ro p e rtie s of DRG neu ro n s. T he presence of tra n sc rip tio n factors w hich a ... See full document
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Drug targets: ligand and voltage gated ion channels
... this ion channel is involved in synaptic transmission and signal transmission at neuro-muscular ...central ion conducting ...the ligand induces conformational change and results in influx of cations ... See full document
11
Chemical-Scale Studies of G Protein-Coupled Receptors and Ligand-Gated Ion Channels
... Not surprisingly, P89 2.59 , which is located in a helix that is not intimately involved in ligand binding nor conformational changes, is generally tolerant of mutations and does not show any obvious trends in the ... See full document
209
Functional modifications of acid-sensing ion channels by ligand-gated chloride channels
... acid-sensing ion channels (ASICs) and epithelial sodium channels (ENaC) constitute the majority of voltage- independent sodium channels in ...chloride channels but occurred with both ... See full document
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Investigation of the domain assembly in ligand-gated and voltage-gated ion channels using computational methods
... Therefore, ligand based chemogenomics was applied in a first step by searching for ligands that are effective on VGICs as well as on another protein ...tein ligand complex structure, which contains ... See full document
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Identification of the prokaryotic ligand gated ion channels and their implications for the mechanisms and origins of animal Cys loop ion channels
... Results: Using sensitive sequence-profile searches we have identified homologs of ART-LGICs in several bacteria and a single archaeal genus, Methanosarcina. The homology between the animal receptors and the prokaryotic ... See full document
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I Chemical Scale Studies of Ligand Gated Ion Channels, and II Novel Methods for Phosphonate Synthesis
... Chemistry—General All reactions were performed under argon using solvents that were dried and purified according to the method of Grubbs. 21 All flasks and vials were oven dried at 122 °C and cooled in a desiccator box ... See full document
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Chemical scale investigations of ligand gated ion channels using unnatural amino acids
... contrast ligand- recognition properties between the two ...The studies presented in Chapter 3 use a series of tyrosine analogs to probe the role of tyrosine residues near the ligand-binding site in ... See full document
14
Selective silencing of vertebrate neurons: strategies using invertebrate ligand-gated ion channels
... GIRK channels via coupling to G i/o ...GIRK channels either naturally or transgenically expressed, and because allatostatin is a peptide it will not cross the blood brain barrier and must by directly ... See full document
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Computational Studies of Noncovalent Interactions in Ligand Gated Ion Channels – and Synthesis and Characterization of Red and Near Infrared Cyanine Dyes
... Dennis Dougherty, for being an excellent mentor and teacher. From Dennis I have learned the value of precise experimental design, the guiding principles of physical organic chemistry, and a healthy respect for effective ... See full document
233
Genomics, cys-loop ligand-gated ion channels and new targets for the control of insect pests and vectors
... cys-loop ligand-gated ion channel gene superfamily of the red flour beetle, Tribolium ...Nonneuronal Ligand-Gated Chloride Channels in Drosophila ... See full document
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Coordinated modulation of cellular signaling through ligand gated ion channels in Hydra vulgaris (Cnidaria, Hydrozoa)
... through ligand-gated-ion channels is an ancient characteristic in the animal kingdom, and that the pharmacological properties of these receptors have been highly conserved during ... See full document
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Evolution of voltage gated ion channels at the emergence of Metazoa
... voltage-gated ion channels, as no genomic study on its own can reveal ...Electrophysiological studies of these neurons will hopefully teach us about the native characteristics of their ... See full document
11
The gating mechanism in cyclic nucleotide-gated ion channels
... mutant channels with one exogenous cysteine in S5 and another cysteine in the P-helix, with the aim of establishing an S-S bond between S5 and the P-helix, possibly locking these mutant channels in the open ... See full document
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Peptide gated ion channels and the simple nervous system of Hydra
... Evolution, Ligand-gated ion channel, Nervous system, Neuropeptide Introduction: the body plan and behaviors of Hydra The Hydra polyp lives in fresh water and has a hollow tube-like shape with a ... See full document
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CiteSeerX — Immobilizing the Moving Parts of Voltage-gated Ion Channels
... of ion channels typically in- volves two types of physically distinct participants, volt- age sensors that move in response to changes of mem- brane potential, and gates that control access to the ... See full document
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Mechanism of Inhibition of Cyclic Nucleotide gated Ion Channels by Diacylglycerol
... closed channels, regardless of ligand ...preliminary studies with the cloned channel resulted in development of a new method of administering DAG to the patch without the use of Teflon (see materials ... See full document
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Biophysical properties of voltage gated Na+ channels in frog parathyroid cells and their modulation by cannabinoids
... while CB 2 is present exclusively in immune cells. CB 1 is a typical G i/o -coupled receptor and can initiate various signaling events (Piomelli, 2003). These include closure and opening of ion channels, ... See full document
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