[PDF] Top 20 Bisphosphonate action Alendronate localization in rat bone and effects on osteoclast ultrastructure

... or rat osteoclasts when the amount on the bone surface was around ...that alendronate binds to resorption surfaces, is locally released during acidification, the rise in concentration stops ... See full document

... treat bone disease characterised by increased bone resorption by inhibiting the activity of mature osteoclasts, resulting in decreased bone ...of osteoclast precursor ...i) osteoclast ... See full document

... the effects of alendronate on bone turnover at the site of biopsy, and to investigate the mechanism of action by which al- endronate induced the observed increase in bone density, the ... See full document

... as bone remodelling can be decoupled and the effects of pharmaceutical agents on individual components of the system can be ...other bone diseases, including metastatic bone disease, ... See full document

... the effects of short-term administration of zoledronate, a third genera- tion bisphosphonate, on the metaphysis of the proximal end of tibia in twenty days old male albino ...per osteoclast and area ... See full document

... trabecular bone formation, whereas bisphosphonates reduce bone resorption and ...the effects of 1-yr treatment of 9-mo-old minipigs with sodium fluoride (NaF, 2 mg/kg/d ...or alendronate (ALN, ... See full document

... of bone matrix, which is critical for bone growth) (Ensrud et ...2010). Alendronate promotes bone regeneration and healing of bone tissue damage by decreasing the number of osteoclasts ... See full document

... Integrins consist of a α and β subunit, which each have a large ectodomain, a single transmembrane domain and a generally short cytoplasmic tail. Eighteen α subunits and eight βsubunits can assemble in 24 different ... See full document

... stimulates osteoclast formation, causes mild hypercalcemia, and is produced by bone cells in vitro upon exposure to systemic ...the effects of PTH-rP on Ca2+ homeostasis and osteoclastic ... See full document

... on bone cells such as osteoblasts and ...on osteoclast precursor cells such as bone marrow-derived CD14 ⴙ monocytes and ...of osteoclast-specific markers such as tartrate-resistant acid ... See full document

... trabecular bone mass and enhanced mineralization of Ob, accompanied by a decreased number of Oc and bone resorption activity ...alternative action of ApN, discovered by Huang et ... See full document

... once-yearly bisphosphonate globally approved for use in the treatment of up to 6 indications of ...decreased bone turnover and improved bone density for at least 12 months post ... See full document

... Cutasept® G (Bode, Hamburg, Germany). After local anesthesia with Scandicain 2 % (AstraZeneca GmbH, We- del, Germany), a 2-cm skin incision was performed over the medial surface of the proximal right tibia. After split- ... See full document

... LPS-induced bone destruction, 5-week-old male ICR mice were randomly divided into 3 groups (5 mice per group): Control (treated with PBS), LPS (treated only with LPS), and LPS + ST (treated with both LPS and ... See full document

... Net bone mass represents the relative activities of osteoblasts and osteoclasts, and there is little question that GCs suppress bone-forming cells, in vivo, via a process involving accelerated apoptosis (1, ... See full document

... et al., reported that chitosan inhibits formation of TRACP positive cells. Inhibition of TRACP activity on 2% chitosan in combination with calcium phosphate cement did not result from inhibitory effect at transcription ... See full document

... of bone correlates well with the extent of bone destruction and local recurrence ...hematopoietic osteoclast precursor cells (monocytes) during tumor- induced osteoclastogenesis ... See full document

... Furthermore, these experiments constitute strong evidence that the enhancement of protein synthesis is due neither to an acceleration of amino acid transport nor to synthesis but, rather[r] ... See full document

... Fig. 1 and 2 show longitudinal changes in lumbar BMD, serum levels of calcium and phosphorus, and levels of the bone turnover markers. A significant reduction in urinary NTX level was observed in both groups (both ... See full document

... side effects which are often associated with synthetic antibiotics ...side effects might lies in the structure of the natural products which reacts with toxins and/or patho- gens in such a way that less ... See full document