[PDF] Top 20 Bone resorption predicts for skeletal complications in metastatic bone disease

... skeletal complications. We are not aware of any previous studies in metastatic bone disease that have related Ntx levels to the range of skeletal complications considered ... See full document

... decreased bone strength due to metastatic foci, underlying osteoporosis and/or cancer treatment induced bone ...of metastatic disease involving the skeleton are ...of metastatic ... See full document

... with bone pain associated with metastatic bone disease from prostate cancer, subse- quent trials failed to show convincing clinical activity in preventing skeletal complications, ... See full document

... reduce skeletal morbidity across a wide range of cancer types that affect bone (33 – ...prevent skeletal complications, and current international guidelines (American Society of Clinical ... See full document

... subsequent skeletal-related event (secondary ...on-study skeletal-related event or hypercalcemia of malignancy, with a risk reduction of 17% (HR ...on-study skeletal-related event was ...of ... See full document

... the Bone Most patients with metastatic bone disease have severe bone pain and ...pain. Bone pain is frequently the first sign of metastatic disease and ... See full document

... proach was determined in a trial period during which it was applied to all patients referred to the radiology department for either radionuclide bone scan or radiograp[r] ... See full document

... on bone formation, estrogen was administered to ovariectomized rats in which bone resorption was suppressed by the bisphosphonate 3- amino-1-hydroxypropylidene-1-bisphosphonate ...trabecular ... See full document

... Population study. A total of 1625 Chinese volunteers were recruited from Midwestern Chinese Han adults living in Xi'an and Changsha cities. The study was approved by Xi’an Jiaotong University. Signed informed consent ... See full document

... The reasons for the rare occurrence of extraneural metastasis in primary tumors are not clear (11). Initial theories such as a lack of lymphatics in the brain, inability of neural tissue to grow outside of the central ... See full document

... of skeletal metastases despite regres- sion of visceral metastases ...static disease as one of the top four research priorities in all of Orthopaedic oncology ... See full document

... Quantitative morphologic methods were used to measure the effects of feeding a low phosphorus diet to intact and thyroparathyroidectomized rats on several processes of bone mineralization and turnover. In severely ... See full document

... periodontal disease include poor oral hygiene, smoking and psychological ...periodontal disease progression (Stabholz, Soskolne et ...of disease development may be conferred by genetic elements ... See full document

... Abstract: Bone integrity is maintained throughout life via the homeostatic actions of bone cells, namely, osteoclasts, which resorb bone, and osteoblasts, which produce ...pathological bone ... See full document

... increase bone resorption in cultured fetal rat long bones as measured by the release of previously incorporated ...total bone 45Ca during 5 days of ...of bone resorption was not ... See full document

... body bone scintigraphy is that 18F –NaF PET/CT generally has a higher sensitivity and speci ficity than bone ...of bone marrow lesions are all contributing factors to the success of 18F –NaF PET/CT [7 ... See full document

... by bone marrow cells and bone cells, has been implicated in the pathogenesis of postmenopausal osteoporosis because of its potent stimulatory effects on bone resorption in vitro and in ... See full document

... osteo clasts can produce the pro-infl ammatory cytokine TNF [28,29]. Both soluble and membrane-bound TNF bind to the TNF receptors TNFR1 (p55) and TNFR2 (p75). TNFR1 mediates most of the biological eff ects of TNF. ... See full document

... in bone-resorbing active, but not inactive, ...in bone marrow macrophages (BMMs) and preosteoclasts (pOCs) and only mod- estly expressed in multinucleated mature osteoclasts prepared on plastic dishes, but ... See full document

... the resorption of the dental bones is one of the main factors that leads to biological and/or mechanical failure of implant-supported dental restorations ...perspective, bone resorption causes the ... See full document