[PDF] Top 20 Brc1-Mediated DNA Repair and Damage Tolerance
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Brc1-Mediated DNA Repair and Damage Tolerance
... to DNA damage and pass through ...in DNA damage ...to DNA damage that can be partially suppressed in rad52 mutants, suggesting inappropriate recombina- tion at the repetitive ... See full document
12
TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1
... more DNA breaks than did deletion of either gene alone (Figure 1b and c, P < ...break repair scaffold protein, Xrcc1 (Supplementary Figure ...of repair during subsequent incubation in CPT-free ... See full document
10
Proteomic analysis of mismatch repair-mediated alkylating agent-induced DNA damage response
... A number of protein phosphorylation sites were found to be up-regulated in MNNG-treated TK6 nuclear prote- ome, but not in MT1 (Figure 3). Many of these proteins, such as RAD50, RBBP8, SMC3, TOP2A and TP53B (see ... See full document
14
Revisiting DNA damage repair, p53 mediated apoptosis and cisplatin sensitivity in germ cell tumors
... the repair of spontaneously arising DNA damage, cells with HR defects exhibit a high frequency of chromosome aberrations (Pierce et ...of DNA damage by exogenous ...DSB repair ... See full document
9
Expanding the Repertoire of DNA-Mediated Signaling in DNA Repair
... of damage sources, ranging from endogenous reactive oxygen species and chemical damaging agents to external high energy UV light (1, ...causes damage that, if unrepaired, leads to extended genomes, ... See full document
209
Nonstructural Protein 5A Impairs DNA Damage Repair: Implications for Hepatitis C Virus-Mediated Hepatocarcinogenesis
... the DNA damage sensor protein complex Mre11-Rad50-NBS1 as well as ATM ...damaged DNA repair ...to DNA damaging ...impaired DNA damage ...of DNA damaging ... See full document
19
DNA Damage, Repair, and Cancer Metabolism.
... to repair DNA damage, and inhibit cell-cycle progression until ...to repair the DNA damage contradicts the reduced glutamine consump- ...the DNA repair enzyme ... See full document
8
Chromatin structure and DNA damage repair
... both DNA repair and tran- scription require access to DNA, it is not surprising that a number of remodelling proteins and histone modifica- tions that are associated with active transcription are ... See full document
13
DNA Mediated Charge Transport in DNA Repair
... this DNA-mediated CT process can be considered as a scan of the integrity of intervening DNA, since DNA-mediated CT can only proceed through a well stacked ...the ... See full document
261
Functions of DNA Damage Response Factors in Lymphocyte Development and Transformation
... DSB repair factors (Bassing et ...of DNA strands between a pair of gene segments and their flanking RSSs to generate covalently sealed coding ends (CEs) and blunt signal ends (SEs) (Fugmann et ...RAG ... See full document
198
The Homologous Recombination Repair Pathway is Associated with Resistance to Radiotherapy in Nasopharyngeal Carcinoma
... of DNA lesions, which in replicating cells often results in deleterious DNA double-strand breaks (DSBs) ...in DNA damage repair in nonprolifera- ting cells, thus inhibiting NHEJ is ... See full document
12
DNA Repair Mechanisms and the Bypass of DNA Damage in Saccharomyces cerevisiae
... major DNA-damage re- pair pathway—base excision repair—were absent among the early rad mutants and that most were identified ...The damage-reversal and excision-repair pathways that ... See full document
40
Stationary Phase Persisters to Ofloxacin Sustain DNA Damage and Require Repair Systems Only during Recovery
... where tolerance is achieved with a reduction in corruption of the antibiotic’s primary ...antibiotic-induced damage than their kin that were also nongrowing but succumbed to the treat- ...binds ... See full document
11
Poor recognition of O6-isopropyl dG by MGMT triggers double strand break-mediated cell death and micronucleus induction in FANC -deficient cells
... plasmid is similar to that of wild-type cells and is significantly different from the survival curve of FANCD2 mutant cells (Figure 2A). The obtained LC 50 values were 75.99 µM, 253.4 µM and 355.1 µM in FANCD2, FANCD2+wt ... See full document
14
Repair of Topoisomerase-Mediated DNA Damage in Bacteriophage T4
... (pBS4). DNA sample collection times are in minutes postinfec- ...three repair products are labeled RC (right crossover), NC (noncrossover), and LC (left crossover); we do not know whether these three bands ... See full document
10
Chromatin modifiers and remodellers in DNA repair and signalling.
... DSB repair in G0/G1 phase cells occurs via a resection-mediated process of c-NHEJ [31], which arises in a manner akin to HR in late S/G2 phase cells ...how damage induced chromatin modifications and ... See full document
13
The NuA4 Complex Promotes Translesion Synthesis (TLS)-Mediated DNA Damage Tolerance
... the DNA DSB response, where it is transiently deposited into chromatin on one side of the break, promoting DNA resection (Kalocsay et ...canonical DNA damage checkpoint factors, such as CHK1 ... See full document
24
Characterisation of non essential genes required for survival under conditions of DNA stress
... of DNA called autonomously replicating sequences (ARS) instead of OriC, at which DNA replication begins (Liachko and Dunham, ...mammalian DNA replication, in which origins are more complex as ... See full document
353
Prevention of DNA damage and anticarcinogenic activity of Activia in a preclinical model.
... of DNA damage frequency. However, the damage was probably repaired since the product showed no mutagenic ...the damage was not fixed on the cellular genome, in the form of micronuclei, ... See full document
12
Dynamic changes to survivin subcellular localization are initiated by DNA damage
... and DNA-PK detect and transduce UV damage signals and in order to unravel a possible role for survivin in this pathway, the ability to eliminate more than one of the DNA damage-sensing ... See full document
9
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