[PDF] Top 20 Cancer biomarker HER-2/neu in breast cancer in Indian women

... serum HER-2/neu levels, menopausal status and stage of ...serum HER-2/neu levels between patients with different age groups, node status and hormone receptor (ER, PgR) ...serum ... See full document

... with breast cancer and underwent curative surgery at Grant Medical College and Sir JJ Group of Hospitals, Mumbai, India, from May 2007 to October 2010 were included in the ...i) breast cancer ... See full document

... for breast-conservative surgery without increasing local recurrence rates, with possibly an improved ...several cancer biomarkers will be more informative than a single ... See full document

... between HER-2/neu protein over- expression and most of the hormone-related breast cancer risk factors does not completely agree with several hypotheses which have maintained that ... See full document

... Background: Breast cancer is a major medical problem with significant public health and societal ramifications and is a leading cause of cancer death in ...of breast cancer (luminal A, ... See full document

... manufacturers. Breast cancer in premenopausal women has a different biopathologic profile from that in older patients, with a pre- dominance of unfavorable prognostic parameters, includ- ing a higher ... See full document

... that breast cancer progression is often associated with alterations in expressions of ER, PR, HER-2/neu, p53 and ...and Her-2 leads to lower or absent hormone receptors in ... See full document

... We then calculated the survival of patients from initial diagnosis for three scenarios: primary tumor negative and both the first and second metastases were also negative; pri- mary tumor positive and both the first and ... See full document

... that cancer frequency is on the increase; and an expectation that maybe with the advances in technology, cancer is analyzed perhaps a change in our attitude and approach, the ethnicities associated with ... See full document

... In the present study, p53 immunoexpression was detected in 37.10% of the ductal carcinomas cases and in 25% of invasive lobular carcinoma only (Table 1). P53 Immunoexpression was also detected in 38.30% of those tumors ... See full document

... At 9 years, disease relapses were seen in 33 patients (22 of 48 node-negative patients and 11 of 25 node-positive patients); 30 women died from breast carcinoma. The 9-year RFS and OS were 52% and 61%, ... See full document

... and 2 μl of total ...Human Breast Cancer miScript miRNA PCR Array (SABiosciences), containing replicates for miRNA reverse transcription control assay (miRTC) and a posi- tive PCR control ... See full document

... in women are cancer of uterus, cervix, breast and oral ...cavity. Cancer of cervix and breast in females account for over 50% of all cancer deaths in ...alter breast ... See full document

... 18. Underwood M, Bartlett J, Reeves J, Gardiner DS, Scott R, Cooke T. C-erbB-2 gene amplification: a molecular marker in recurrent bladder tumors? Cancer Res 1995; 55: 2422–30. 19. Vollmer RT, Humphrey PA, ... See full document

... now also being examined in combinatorial studies. Preclinical data had suggested that trastuzumab could increase cross presentation of the E75 epitope and more ef fi cient expansion of speci fi c CD8 + T cells. The fi rst ... See full document

... of breast cancer in recent years has led to the discovery of important drug targets such as HER-2 and ...of HER-2 and ...including breast cancer, and the drug is ... See full document

... Breast is made up of parenchymal tissues composed of branching ductal system which are radiating from the nipple. 15-20 mammary lobules are usually present in breast parenchyma. Lactiferous duct drains the ... See full document

... The term alexithymia is a complex multidimensional construct that literally means “no words for mood”. There are two kind of alexithymia: primary and secondary or otherwise called trait and state alexithymia. There is ... See full document

... words, women who had received a positive result (that is, who discovered they had a genetic predisposition to developing breast/ovarian cancer) did not show in the short term higher levels of ... See full document

... with HER-2/neu gene amplification, overexpres- sion of HER-2/neu was not associated with survival in sev- eral studies [4,5,33] even though others found a prognostic impact ...of ... See full document