[PDF] Top 20 Cancer-secreted AGR2 induces programmed cell death in normal cells
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Cancer-secreted AGR2 induces programmed cell death in normal cells
... of AGR2 appears to be the down-regulation of SAT1, which was also observed in UV- irradiated ...by AGR2 treatment and irradiation, which in turn affects intracellular polyamine levels, could be the trigger ... See full document
10
Bacterial programmed cell death of cerebral endothelial cells involves dual death pathways
... with cells of the BBB and the blood-CSF bar- rier ...endothelial cells during invasion (2) or kill at a distance by secreted toxins ...pneumococcal cell wall (PCW), consisting of a multilay- ... See full document
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Emodin induces apoptosis of human cervical cancer hela cells via intrinsic mitochondrial and extrinsic death receptor pathway
... Total RNA was extracted by a Trizol reagent kit (Invitrogen, USA) after the HeLa cells treated with emo- din (0, 20, 40 and 80 μM) for 48 h. The quality of each RNA sample (including its concentration and purity) ... See full document
8
A mono-carbonyl analog of curcumin induces apoptosis in drug-resistant EGFR-mutant lung cancer through the generation of oxidative stress and mitochondrial dysfunction
... in programmed cell ...H1975 cells, this ER–mitochondria interface certainly appears to be involved in cytotoxicity of ...causing cell death needs to be explored ... See full document
14
Neuronal programmed cell death induces glial cell division in the adult Drosophila brain
... BrdU-positive cells did not increase prominently ...glial cells and/or trigger another round of cell division, for the most part, the same glial cells are likely to be activated by PCD and ... See full document
9
Danusertib, a potent pan-Aurora kinase and ABL kinase inhibitor, induces cell cycle arrest and programmed cell death and inhibits epithelial to mesenchymal transition involving the PI3K/Akt/mTOR-mediated signaling pathway in human gastric cancer AGS and NCI-N78 cells
... Gastric cancer is the second leading cause of cancer-related death worldwide, with a poor response to current ...gastric cancer are ...on cell growth, apoptosis, autophagy, and ... See full document
26
Original Article Inhibition of cell migration and invasion and promotion of cell apoptosis by overexpression of programmed cell death 4 (PDCD4) in cervical cancer Siha cells
... Cervical cancer has been one of the leading causes of cancer-related deaths among women ...that programmed cell death 4 (PDCD4), a new tumor suppressor, participates in the ... See full document
8
Triptolide induces lysosomal-mediated programmed cell death in MCF-7 breast cancer cells
... Uniform normal adhesive and colonized cells were observed in the control group (Figure 1A), whereas significant reduction in colony formation of the experimen- tal groups could be observed in a ... See full document
13
Programmed cell death in the skin
... major cell type in the epidermis and divide constantly to generate new ...The programmed cell death or terminal differentiation program occurring to keratinocytes is referred to as ... See full document
7
CLEC3B as a potential diagnostic and prognostic biomarker in lung cancer and association with the immune microenvironment
... PD-1: Programmed cell death receptor-1; PD-L1: Programmed cell death ligand-1; NSCLC: Non- small-cell lung cancer; ADC: Adenocarcinoma; SCC: Squamous cell ... See full document
15
Distinct effects of TRAIL on the mitochondrial network in human cancer cells and normal cells: role of plasma membrane depolarization
... malignant cells and normal cells. Live-cell imaging revealed that multiple human cancer cell lines and normal cells exhibited two different modes of mitochondrial ... See full document
17
The calcimimetic R-568 induces apoptotic cell death in prostate cancer cells
... apoptotic cell death in parathyroid cells in addition to reducing PTH secretion ...prostate cancer cell lines, androgen receptor- positive LNCaP cells and androgen ... See full document
8
Novel technologies and emerging biomarkers for personalized cancer immunotherapy
... T cells), the production of inducible T-cell alpha chemo- attractant (ITAC), interferon-gamma (IFN-γ) and ...mune cells analyzed by immunohistochemisty (IHC) is associated with response to ... See full document
25
Persistent mutant oncogene specific T cells in two patients benefitting from anti-PD-1
... We used the MANAFEST (Mutation Associated NeoAn- tigen Functional Expansion of Specific T-cells) assay [15] to evaluate T-cell responsiveness to mutation-associated neoantigens. Briefly, putative ... See full document
8
<p>BTLA Expression in Stage I–III Non–Small-Cell Lung Cancer and Its Correlation with PD-1/PD-L1 and Clinical Outcomes</p>
... T cells but lowly expressed in naïve T cells, B cells, natural killer cells, macrophages, and dendritic ...T cells. BTLA signaling molecules affect not only Th1 cells, but also ... See full document
10
Immune biomarkers of treatment failure for a patient on a phase I clinical trial of pembrolizumab plus radiotherapy
... Case presentation: The patient is a 64-year-old male with metastatic clear cell renal cell carcinoma, Fuhrman grade 4, pathologically staged as T3 N0. Metastatic disease was well controlled for several ... See full document
7
The combination of anti-KIR monoclonal antibodies with anti-PD-1/PD-L1 monoclonal antibodies could be a critical breakthrough in overcoming tumor immune escape in NSCLC
... killer cell Ig-like receptor (KIR) was correlated with poor prognosis of NSCLC, and inhibitory KIR expression was positively correlated with the expression of ... See full document
6
miR-135b-5p enhances doxorubicin-sensitivity of breast cancer cells through targeting anterior gradient 2
... MCF-7 cells by transducing cells with a lentivirus vector expressing double strand miR-135b ...of cells in the absence of doxorubicin ...MCF-7 cells increased doxorubicin-sensitivity as ... See full document
13
The expression status and prognostic significance of programmed cell death 1 ligand 1 in gastro­intestinal tract cancer: a systematic review and meta-analysis
... Background: Programmed cell death 1 ligand 1 (PD-L1) expression has been observed in various ...tract cancer remains ...tumor cells of digestive tract cancer is not ... See full document
9
Impaired dendritic cell functions in lung cancer: a review of recent advances and future perspectives
... lung cancer, significant challenges are still remain on their wide adoption in clinical ...small cell lung cancer patients and found no survival dif- ferences between ...lung cancer till ... See full document
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