[PDF] Top 20 Cancer Stem Cell Plasticity – A Deadly Deal

... of stem cells such as self-renewal, multipotency and maintenance of an undifferentiated cell state have been shown to be governed by intracellular and extracellular components present in their ... See full document

... UM cell lines SOM 157d and SOM 196b were organized in a hierarchical manner, cells were seeded out into clonogenic ...UM cell lines, colony morphologies remained consistent with no variation in cell ... See full document

... advanced cancer and chemoresistant disease ...the stem cell phenotype ...of cancer and CSCs. Cancer epi- genetics research has led to the field of translational epige- netics, a growing ... See full document

... that stem cells with normal embryonic epigenetic characteristics have been selected, or that they undergo further reprogramming as stem cells in vitro or in vivo when incorporated as tissue ... See full document

... of stem cells – ability for self-renewal without loss of proliferation capacity with each cell ...of stem cells. The origin of these resident cancer stem cells is not ...the ... See full document

... Established cell lines were seeded out at 2 3 10 3 cells per 60- mm dish and allowed to give rise to colonies over a period of 14 days. Classification of each colony was determined depending on their morphology ... See full document

... Cancer cell plasticity refers to the ability to reversibly interchange between distinct cell ...of cancer cell pools, activation of facultative cancer stem cells ... See full document

... breast cancer stem cells (BCSCs), which possess the capacity for self-renewal and differentiation, are responsible for tumor initiation, proliferation and progression ...between cancer cells and ... See full document

... TNBC cell lines, high levels were detected in Ep/ non-CSC from transformed HMECs as well as in BT549 cells (Additional file 1: Figure ...maintaining cancer cells in a non-aggressive, epithelial, non-CSC ... See full document

... oval cell line WB-F344 via activation of Wnt/β-ca- tenin pathway ...a cell culture model where HCC cell lines were treated with 10 ng/ml TGF-β1 for 4 to 6 days, miR-125b was found to be ... See full document

... lung cancer lines abolished the expression of E-cadherin by activation of Slug in a miR-675 dependent manner, suggesting a biological function of H19 in the regulation of ...pluripotent stem cells (iPSCs) ... See full document

... breast cancer, MET CSCs are characterized by high ALDH activity and enhanced proliferative capacity, whereas EMT CSCs are identified by the expression of the CD44 hi /CS24 – surface markers and a slow-cycling, ... See full document

... The plasticity of cancer cells and the genetic-independ- ent acquisition of therapeutic resistance may be tightly associated with metabolic ...of cancer and has also been observed in CSCs (reviews in ... See full document

... non-stem cancer cells, and between CSCs and nor- mal progenitor stem cells, will be crucial to develop new therapies and may reveal new ways to distinctively target these ...normal stem cells ... See full document

... muscle stem cells, through en- hanced mitochondrial function and metabolic benefits (Cerletti et ...germline stem cells and ex- tends lifespan, implying that dietary intervention can re- verse the decline ... See full document

... asymmetric cell division is based on the assumption that CSCs and non-CSCs are epigeneti- cally stable and can thus propagate in a mutually inde- pendent ...established cancer cell lines or in tumors ... See full document

... of cancer stem cells or stem cell-like cells to ...the cancer stem cells from leukemia displayed the resistance to duanorubicin and Ara-C 153 ...Similarly cancer ... See full document

... Since the publication of the Radiologic Diagnostic Oncology Cluster Report in 1991, the clinical application of pulmonary resonance imaging (MRI) in patients with lung cancer has been restricted. In distinction, ... See full document

... the Cell Titer 96 Aqueous One Solution Cell Proliferation Assay (Promega, Madison, WI, USA), which is a colorimetric method for determining the number of viable cells based on bioreduction of the ... See full document

... gastric cancer, breast cancer, liver cancer, etc ...gastric cancer is related to the invasion depth of gastric cancer and lymph node metastasis but negatively correlated to the CD3-ξ ... See full document