[PDF] Top 20 Cancer stem cell markers predict a poor prognosis in renal cell carcinoma: a meta-analysis

... (EMT) [31]. Consistent with the previous report, our study suggests that high expression of CD44 significantly correlate with unfavorable OS, CSS and DFS. There are a few references about the relationship between CD133 ... See full document

... to cancer stem-like cell ...and prognosis of CSC markers, and VM is not still clear in non-small cell lung cancer ...epithelial cell adhesion molecule [EpCAM], ... See full document

... SUNE1 cell lines with ISG15 overexpression (Figure 4A) and performed a series of in vitro experiments with these ...CSC markers by real time PCR ...NPC cell line CNE2 (Figure 5A and 5B and 5C); ... See full document

... regulate cell growth and ...in cell signaling and cell migration [8, 10, 11] as well as interacting with a range of ECM components ...secretome analysis, Blanco et ...in cancer is still ... See full document

... breast cancer by promoting the expression of the apoptosis-regulated gene GADD45α and suppressor gene Maspin ...on cancer-specific contexts and its role in RCC remains ... See full document

... to predict outcome using targeted therapy in metastatic ccRCC exhibited some promise but further validation is needed ...The prognosis of mRCC is poor and the primary treatment is molecular-targeted ... See full document

... In conclusion, high expression of Twist is signifi- cantly correlated with pathological features such as grade, pT stage, and the presence of metastasis in patients with RCC. In addition, its expression is also ... See full document

... lymph node metastasis. However, no statistically significant associations were found in other clinicopathological features, including age, tumor size, and tumor location. Furthermore, a multivariate analysis ... See full document

... Renal cell carcinoma (RCC) represents one of the most common type of renal cancer, accounting for 90% of adult renal malignancies ...The prognosis of advanced RCC is very ... See full document

... All data were extracted and verified independently by two investigators based on the above selection criteria. The general data of the selected studies included first author and publication year. The clinical data of ... See full document

... Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cell ...univariate analysis found that cytoplasm CHD9 expression in cancer tissues was ... See full document

... adjunctive to other protective systems (such as adaptive immunity). However, complement has been largely extended in its role in both withstanding exogenous invasion or handling endogenous threats (such as cancer) ... See full document

... between cancer stem cell (CSC) markers and clinical features in nasopharyngeal carcinoma ...a meta-analysis to explore the relationship between CSC markers and ... See full document

... other cell surface molecules such as CD44, CD24, CD166 and EpCAM have been verified as putative CSC markers in ...these markers could provide a better selection of ...to predict low patient ... See full document

... The introduction of tyrosine kinase (TKIs) and mTOR inhibitors has completely revolutionized the therapeutic scenario of mRCC, suddenly replacing immunotherapy as the standard of care for these patients. Seven agents ... See full document

... with prognosis of tumor ...urothelial carcinoma associated 1 (UCA1), which could pro- mote aggressiveness of cancer cell, is associated with prog- nosis of multiple tumor such as bladder ... See full document

... called cancer stem-like cells (CSC), which exhibit self-renewing capacities and are responsi- ble for tumor maintenance and metastasis [3] and pos- sibly for resistance towards chemotherapy and radiation ... See full document

... Our study also has some limitations: first, this is a retrospective study, the findings might not apply to the general population. Larger prospective studies are needed to confirm our conclusion. Second, we used TMA to ... See full document

... tumorigenic properties in vivo after pre-irradiation. This is in line with recently published data from Bertrand et al., who showed that inhibition of ALDH activity by the treatment with all-trans retinoid acid (ATRA) ... See full document

... cases, renal mass biopsy is mandatory, for adequate risk stratification, which requires accurate diagnosis [4, ...in renal mass biopsy, it is non-diagnostic in approximately 15% of patients, more frequently ... See full document