[PDF] Top 20 Capsid assembly and involved function analysis of twelve core protein mutants of duck hepatitis B virus.
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Capsid assembly and involved function analysis of twelve core protein mutants of duck hepatitis B virus.
... Much attention was focused on the C-terminal region of this protein, in which several domains have been found to mediate different functions in the viral life cycle; e.g., the C-terminal[r] ... See full document
8
Signals for Bidirectional Nucleocytoplasmic Transport in the Duck Hepatitis B Virus Capsid Protein
... a protein of 30 kDa ...complete core sequence (GFP–C5-262) led to a cytoplasmic localization of the fluorescent GFP signal ...67 core protein amino acids, expected to abrogate capsid ... See full document
10
Conformational Changes in the Hepatitis B Virus Core Protein Are Consistent with a Role for Allostery in Virus Assembly
... prevented assembly but also raises barriers to a more complete ...the protein. Most of the residues involved were within the upper half of the spike or close to hinges in the spike and fulcrum ... See full document
9
Identification of Residues in the Hepatitis C Virus Core Protein That Are Critical for Capsid Assembly in a Cell-Free System
... for assembly-competent ...or assembly-incompetent mutants ...or core mutants as well as other complexes (in fractions 3 and 4) formed by core mutants that display a ... See full document
14
Cell-Free Hepatitis B Virus Capsid Assembly Dependent on the Core Protein C-Terminal Domain and Regulated by Phosphorylation
... the assembly of the WT and mutant capsids in detail, we turned to the mammalian cell system (HEK293 cells) for produc- ing large amounts of capsids from either the WT HBc or CTD phosphorylation ...7A capsid ... See full document
15
Nucleolar Localization of Human Hepatitis B Virus Capsid Protein
... human hepatitis B virus (HBV) exhibits selective export of virions containing mature ...HBV core antigen (HBcAg) causes it to release immature ...mutagenesis. Twelve of the 18 ... See full document
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Monoclonal Antibodies Providing Topological Information on the Duck Hepatitis B Virus Core Protein and Avihepadnaviral Nucleocapsid Structure
... ticle assembly still identified specific regions involved in epitope formation, namely, around E72, E95 and E97, and ...the capsid surface is highly ...the involved residues at the inner ... See full document
5
Mapping of Homologous Interaction Sites in the Hepatitis B Virus Core Protein
... Functional analysis of the relevance of regions I and II in HBV capsid ...c1–149 protein was the lack of a de- tectable assembly defect of region I variants at T91 and/or K96 when analyzed in ... See full document
9
A hydrophobic heptad repeat of the core protein of woodchuck hepatitis virus is required for capsid assembly.
... of capsid assembly-defective mutants in prokaryotic ...the assembly situation of all assembly-defective mutants in intact cells, we reexamined by EM all of the mutants in ... See full document
7
Assembly Properties of Hepatitis B Virus Core Protein Mutants Correlate with Their Resistance to Assembly-Directed Antivirals
... between protein residues and thus provide limited information regarding the role of a given residue in capsid ...microsecond-long capsid simulations showed high correlations with both crystallo- ... See full document
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Insertions within the hepatitis B virus capsid protein influence capsid formation and RNA encapsidation.
... the capsid sufficiently to generate detectable phe- notypes without totally destroying capsid ...to b strands would be potentially more disrup- tive than alterations to the less structurally ... See full document
6
Small-Molecule Effectors of Hepatitis B Virus Capsid Assembly Give Insight into Virus Life Cycle
... the capsid protein(8); in vitro, HAPs accelerate and can misdirect assembly ...Normal capsid assembly is characterized by a slow nucleation rate and weak pairwise association energies ... See full document
9
Residues Critical for Duck Hepatitis B Virus Neutralization Are Involved in Host Cell Interaction
... contrast, analysis of the SIP and SIH mutants has re- vealed that these double and triple amino acid substitutions abrogate DHBV infectivity in vitro and in vivo without affect- ing their replication ...of ... See full document
7
A protease-sensitive hinge linking the two domains of the hepatitis B virus core protein is exposed on the viral capsid surface.
... 5548 Downloaded from http://jvi.asm.org/ on November 9, 2019 by guest Core particles of hepatitis B virus are assembled from dimers of a single 185-residue subtype adw viral capsid or co[r] ... See full document
8
Discovery and Mechanistic Study of Benzamide Derivatives That Modulate Hepatitis B Virus Capsid Assembly
... DNA virus, HBV replicates its genome via the protein-primed reverse transcription of an RNA pregenome in a cytoplasmic nucleocapsid ...HBV core protein is a small polypeptide of 183 amino acid ... See full document
18
The duck hepatitis B virus core protein contains a highly phosphorylated C terminus that is essential for replication but not for RNA packaging.
... Removal of the last 12 C-terminal DHBcAg amino acids, which are at least in part located on the core particle surface, had only a minor effect on DHBcAg phosphorylation and did not inter[r] ... See full document
6
Naturally Occurring Mutations Define a Novel Function of the Hepatitis B Virus Core Promoter in Core Protein Expression
... fulminant hepatitis (2, 9, 31, 34, 36). The MT5/6-induced increase in core protein expression and increased replication could potentially play an important role in the pathogenesis of fulminant ... See full document
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Chimeric hepatitis B virus core particles with parts or copies of the hepatitis C virus core protein.
... Susceptibility to digestion with proteinase K of HCV core determinants on chimeric core particlesa Conditions Undigested Digested 10 min 60 min A492 of antigenic determinants of: HCV cor[r] ... See full document
7
Functional Surfaces of the Hepatitis B Virus Capsid
... and core protein have been identified which specifically and strictly block virion formation without influencing other detectable features of these proteins (4, 10, 13, ...L protein and CED in CP) ... See full document
8
Interaction between Hepatitis B Virus Core Protein and Reverse Transcriptase
... system. Core-Pol interactions could play a role in multiple steps in HBV ...direct core-Pol interaction even though the encapsidation substrate is an epsilon-Pol RNP ...for protein prim- ing (40). ... See full document
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