[PDF] Top 20 Cardiovascular and gastrointestinal effects of COX 2 inhibitors and NSAIDs: achieving a balance
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Cardiovascular and gastrointestinal effects of COX 2 inhibitors and NSAIDs: achieving a balance
... type 2 diabetes treated with rofecoxib 25 mg/day, but not those treated with celecoxib 200 mg/day or naproxen 500 mg twice daily, had a significant increase in 24 hour systolic blood pressure ...of ... See full document
9
Practical approaches to minimizing gastrointestinal and cardiovascular safety concerns with COX 2 inhibitors and NSAIDs
... of gastrointestinal complications is not reduced in patients who receive concomitant aspirin, the risks and benefits of COX-2 inhibitors must be carefully balanced when considering therapy ... See full document
7
New insights into the use of currently available non-steroidal anti-inflammatory drugs
... the COX-1 and COX-2 isoforms, pharmacokinetic properties, pharmacody- namic interactions, and the overall impact of these features on tolerability and ...the gastrointestinal and ... See full document
14
Should selective Cox-2 inhibitors be used more?
... that COX-2 enzyme has wide distribution throughout the body, and their actions are not just limited to the site of ...selective COX-2 inhibition by coxibs have also proved that COX ... See full document
5
Clinical Study To Establish Efficacy and Safety of Contodol Gel As Topical Pain Relieving Agent
... or NSAIDs, which has to be taken for long-term to reduce both the pain and swelling caused by ...arthritis. NSAIDs are among the most widely used medications, but the side effects of these drugs ... See full document
7
The Role of Cyclooxygenase (COX)-2 in the Canine Proximal Gastrointestinal Tract
... the COX enzyme exist (COX-1 and COX-2) and the manner in which NSAIDs interact with these isoforms is likely accountable for the variability in efficacy and toxicity amongst this class ... See full document
131
Reduction in cancer risk by selective and nonselective cyclooxygenase-2 (COX-2) inhibitors
... of gastrointestinal and other side effects associated with NSAID use, the vast majority of individuals who take them, even at therapeutic doses, do not appear to suffer serious side effects or ... See full document
6
Nitric oxide and cardiovascular effects: new insights in the role of nitric oxide for the management of osteoarthritis
... traditional NSAIDs and COX-2 selective NSAIDs appear to increase blood pressure, but there are variations between individual ...traditional NSAIDs were 2.83/1.34 mmHg and with coxibs ... See full document
12
Prevention of NSAID-related upper gastrointestinal toxicity: a meta-analysis of traditional NSAIDs with gastroprotection and COX-2 inhibitors
... a COX-2 instead of a tNSAID, each reduce the incidence of endoscopically detected upper GI ulcerations, and clinically important upper GI events such as ...adverse effects which may limit its ... See full document
25
Nonsteroidal anti inflammatory drugs (NSAIDs), cyxlooxygenase 2 selective inhibitors (coxibs) and gastrointestinal harm: review of clinical trials and clinical practice
... adverse effects. NSAIDs (and aspirin) are associated with upper [3] and lower [4-6] gastrointestinal harm, acute renal failure [7,8] and congestive heart failure ...[9,10]. Cox- ibs are ... See full document
13
Balancing the gastrointestinal benefits and risks of nonselective NSAIDs
... decreased gastrointestinal risk in patients receiving COX-2 is reviewed extensively ...serious gastrointestinal adverse events from clinical trials, and outcome studies have demonstrated the ... See full document
7
A broad-spectrum lipidomics screen of antiinflammatory drug combinations in human blood
... was 2-propanol /methanol (5:5, v/v). The linear gradient was as follows: 2% B at 0 minutes, 2% B at 3 minutes, 8% B at 11 minutes, 8% B at 13 minutes, 95% B at 17 minutes, 2% B at 18 minutes, ... See full document
17
ANTI INFLAMMATORY AND ANTIPYRETIC ACTIVITY OF SELECTIVE COX 2 INHIBITOR WITH CONVENTIONAL NSAIDs
... conventional NSAIDs alone and for antipyretic activity it was found that Etoricoxib in combination with diclofenac shows more effective than the Etoricoxib alone but lees as compare to the ...side effects ... See full document
7
Efficacy and tolerability of naproxen/esomeprazole magnesium tablets compared with non-specific NSAIDs and COX-2 inhibitors: a systematic review and network analyses
... Notes: The results of the direct meta-analyses (Direct) and mixed-treatment comparisons (MTC) are displayed within this figure as “forest plot” diagrams. These diagrams display the results from analysis of ... See full document
19
Comparison of NSAIDs activity in COX-2 expressing and non-expressing 2D and 3D pancreatic cancer cell cultures
... Spheroids were formed by the 3D bioprinting method from BxPC-3, MIA PaCa-2 cells mixed with human fibroblasts (1:1) to better imitate the tumor microenvironment. Cells were incubated with nanoparticles NanoShuttle ... See full document
9
Inhibition of cyclooxygenase-2 prevents intra-abdominal adhesions by decreasing activity of peritoneal fibroblasts
... COX-2 inhibitors, through their antiangiogenic properties, inhibit intra-abdominal adhesions in an experimental murine ...both COX-2 inhibitors (celecoxib and parecoxib) have ... See full document
16
Comparison of prophylactic effect of UGIB and effects on platelet function between PPIs and H<sub>2</sub>RAs combined with DAPT: systematic review and meta-analysis
... Results: Twelve clinical trials (n=3,301) met the inclusion criteria. Compared to H 2 RAs, PPIs lessened UGIB (RR =0.16, 95% CI: 0.03–0.70), and there was no significant difference in the incidence of PRUs (MD ... See full document
11
Discovering COX-2 Inhibitors from Flavonoids and Diterpenoids
... of COX-2 are Arg120, Tyr348, Val349, Leu359, Leu352, Ser353, Tyr355, Leu384, Tyr385, Trp387, Met522, Val523, Gly526, Ala527, Ser530, ...of COX-2 protein were involved for protein–ligand ... See full document
8
Cyclooxygenase selective inhibition of prostanoid formation: transducing biochemical selectivity into clinical read outs
... nonaspirin NSAIDs have a reduced risk of colorectal cancer ...in COX-isozyme expres- sion or activity ...of COX-2 in intestinal epithelial cells, stro- mal cells, or endothelial cells of newly ... See full document
8
Tolerance to alternative cyclooxygenase-2 inhibitors in nonsteroidal anti-inflammatory drug hypersensitive patients
... NSAIDs (non-steroidal anti-inflammatory drugs) are the most universally used analgesics and are responsible for about 21-35% of all drug hypersensitivity reactions [1-3]. Symptoms vary from cutaneous (urticaria ... See full document
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