[PDF] Top 20 CBFA2T2 is Associated with a Cancer Stem Cell State in Renal Cell Carcinoma

... of CBFA2T2, as well as several important cancer stem cells factors, including SOX2, OCT4, CD133, NANOG and ALDH1A3, with the and prognosis of patients with RCC, Kaplan–Meier survival analyses were ... See full document

... against CBFA2T2 or control siRNA for 72 h were washed two times with ice cold phosphate-buffered saline (PBS) and lysed in RIPA buffer (50 mM Tris pH ...[29]. Cell lysates were centri- fuged at 12,000×g for ... See full document

... of cancer stem cells (CSCs), which are responsible for cell self renewal, multidifferentiation, tumor relapse, and progression ...several cell surface markers including Prominin- 1(CD133), CXC ... See full document

... CAF: cancer associated fibroblasts; CEA: carcinoembryonic antigen; CSC: cancer stem cell; CSCC: cutaneous squamous cell carcinoma; CT: cytoplasmic tail; CTLA-4: cytotoxic ... See full document

... Renal cell carcinoma (RCC) is among the most common human cancers in the United States, with approximately 63,990 new patients and 14,400 deaths annually ...clear cell renal cell ... See full document

... targeting cell surface markers or signalling pathways, targeting micro environment or blocking epithelial mesenchymal transition, immunotherapy and other approaches as well, leading to the complete eradication of ... See full document

... tastasis occurs in most of patients before treatment, in- cluding bone metastasis and lymph node metastasis [11]. Three cases of lymph node metastasis and two cases of inal pain, waist and abdominal mass, fatigue, fever, ... See full document

... lung cancer, whereas these two polymorphisms showed no significant association with prostate ...mous cell carcinoma (OSCC) subgroup analyses data showed that only 1790 G/A polymorphism has ... See full document

... epithelial cell line Het-1A was evaluated at the mRNA and protein levels in ...significantly associated with advanced histological grade and poor patient ... See full document

... nificantly associated with the poor prognosis of some cancers, including esophageal, colorectal and urologi- cal cancers, and it has already been reported to be a prognostic marker in relevant cancers ...closely ... See full document

... factor associated with the cascade of hypoxia inducible tumour growth ...thrombi associated with angiogenic activity ...clear cell RCCs with VHL mutations, despite normal oxygenation ...clear ... See full document

... higher rates of TNBC. In addition, patients with low PD-1 and PD-L1 expressions had a significantly longer DFS. In particular, low PD-1 and PD-L1 expressions in TNBC were associated with a higher pCR rate and sig- ... See full document

... for cancer therapy, as our recently available therapies are more suc- cessful at eradicating non-cancer stem cells rather than cancer stem cells [4, ...for cancer [6]. Recently, ... See full document

... The Median age was 55 years. Male to female ratio was 1.73:1. Most of patients in this study have ECOG performance status 2 (51.67%). Most common sites of metastasis were lung (66.67%) followed by bone (36.67%) and liver ... See full document

... Combinations of VEGFR-TKIs, immune checkpoint inhibitors, and HIF inhibitors may provide good options to overcome drug resistance. Increasing evidence sup- ports a primary role for the HIF-2α subunit in ccRCC over ... See full document

... tissue in a case of metastatic clear cell renal cell carcinoma, a case of papillary thyroid cancer and two 356. cases of prostate cancer[r] ... See full document

... of the independent prognostic marker for clear cell variety of RCCs. (121) The RCC-specific 5-year survival rate is 89% in case of grade 1 tumours, 65% in case of grade 2 tumours and 46% in case of grades III-IV ... See full document

... RCC cell lines de- rived from primary lesions of Japanese females (KRC/Y) and from malignant (ACHN) pleural effusion from Caucasian males with metastatic RCC ...SP cell analysis was carried out through a ... See full document

... was associated with clear cell RCC subtype and that the significance of VAT outweighed the effects of BMI for the predic- tion of RCC pathology subtypes ... See full document

... One of the best understood causal relationships is between human papillomavirus (HPV) infection and squamous neoplasia of the anogenital and head-and-neck regions. HPV is a small, 50- to 55-nm-diameter, nonenveloped, ... See full document