[PDF] Top 20 CD6 expression has no effect on atherosclerosis in apolipoprotein E deficient mice
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CD6 expression has no effect on atherosclerosis in apolipoprotein E deficient mice
... DKO mice to address the role of CD6 in cardiovascular disease given the recent focus of CD6 as a therapeutic target for the treatment of sev- eral autoimmune diseases [16, 19, ...DKO mice ... See full document
5
Effect of 12-O-tetradecanoylphorbol-13-acetate-induced psoriasis-like skin lesions on systemic inflammation and atherosclerosis in hypercholesterolaemic apolipoprotein E deficient mice
... transgenic expression in keratinocytes of the angiopoietin receptor Tie2 was reported to develop systemic inflammation and aortic root vasculitis in one third of the mice at 12 months of age and these ... See full document
10
Allergic lung inflammation promotes atherosclerosis in apolipoprotein E-deficient mice
... Anti-asthmatic prescriptions commonly include corticosteroids. 33,34 Yet evidence suggests corticosteroids produce hyperlipidemia, hypertension, and dyslipidemia, which in turn may increase adverse cardiovascular events. ... See full document
22
Paradoxical enhancement of atherosclerosis by probucol treatment in apolipoprotein E deficient mice
... ol-lowering effect of probucol, however, the present study showed that probucol not only did not retard atherosclerosis in our apoE2/2 mice, but actually accelerated lesional devel- ...the ... See full document
10
Renal denervation promotes atherosclerosis in hypertensive apolipoprotein e-deficient mice infused with angiotensin II
... the effect of renal denervation (RDN) on the severity of atherosclerosis and aortic aneurysm in hypertensive ...Hypertension, atherosclerosis and aortic aneurysm were induced by subcutaneous infusion ... See full document
9
Absence of Interferon Regulatory Factor 1 Protects Against Atherosclerosis in Apolipoprotein E-Deficient Mice
... the effect of IRF1 on SR-AI promoter activation (Figure ...IRF1 expression elicited a robust induction of SR-AI protein, and silencing IRF1 exerted an opposite effect (Figure ...from mice ... See full document
16
Original Article Genistein alleviates atherosclerosis in apolipoprotein E-deficient mice by interrupting the OX40/OX40L pathway
... protective effect of genistein on athero- sclerosis is ascribed to restraining inflamma- tion, while the underlying mechanism has not been fully ...which has recently been shown to be associated with ... See full document
8
Angiopoietin-2 attenuates angiotensin II-induced aortic aneurysm and atherosclerosis in apolipoprotein E-deficient mice
... and atherosclerosis have been associated with aortic macrophage accumulation 6,36 ...MCP-1 expression, which are effects that are closely associated with aortic aneurysm progression and rupture 27,38–41 ... See full document
11
Lipingshu capsule improves atherosclerosis associated with lipid regulation and inflammation inhibition in apolipoprotein E–deficient mice
... W/W) and peptides and these ingredients may influence several risk factors for cardiovascular disease. For example, Gastrodia elata Bl. extract suppresses TNF-α-induced vas- cular inflammatory process and matrix ... See full document
6
Flavonols reduce aortic atherosclerosis lesion area in apolipoprotein E deficient mice: a systematic review and meta-analysis
... aortic atherosclerosis in a mouse ...the effect of isolated flavonoids on aortic atherosclerosis in apolipo- protein E deficient ...overall effect of the flavonoids, and ... See full document
13
Protective effect of sildenafil on the genotoxicity and cytotoxicity in apolipoprotein E-deficient mice bone marrow cells
... anion and hydrogen peroxide levels were augmented in bone marrow cells from apoE −/− mice. These findings are in agreement with Tonini et al. [8], likely due to the hyperactivation of ROS-producing enzymes and the ... See full document
7
Dabigatran etexilate retards the initiation and progression of atherosclerotic lesions and inhibits the expression of oncostatin M in apolipoprotein E-deficient mice
... increased expression of adhesion molecules on endothelial cells. 9,10 Thrombin has also been reported to induce the expression of the proinflammatory chemokine MCP-1 as well as matrix ... See full document
9
Serum Amyloid A Directly Accelerates the Progression of Atherosclerosis in Apolipoprotein E-Deficient Mice
... Total cDNA was amplified by use of Light-Cycler-FastStart DNA Master SYBR Green I (TaKaRa Biotechnology, Dalian, China). It was very important to select the appropriate reference genes in the real- time PCR. Thus, a ... See full document
8
Macrophage specific expression of human apolipoprotein E reduces atherosclerosis in hypercholesterolemic apolipoprotein E null mice
... R E Pitas J Clin ...premature atherosclerosis. To determine if macrophage-specific expression of apoE would decrease the extent of atherosclerosis, we expressed human apoE in macrophages of ... See full document
11
PEP 1 MsrA ameliorates inflammation and reduces atherosclerosis in apolipoprotein E deficient mice
... hyperlipidemic mice through lipid-independent ...PON1 expression. In the meantime, the expression of inflammatory cytokines TNF α and IL-6 was also reduced in the liver of the PEP-1-MsrA injected ... See full document
13
The atheroprotective roles of heart protecting musk pills against atherosclerosis development in apolipoprotein E deficient mice
... consistent with AMPK modification, the phosphorylated HMGCR and ACCα levels were markedly increased in the HMP group. Regarding the upstream kinases responsible for AMPK activation, LKB1 and CaMKKβ are two major upstream ... See full document
16
Adiponectin improves NF-κB-mediated inflammation and abates atherosclerosis progression in apolipoprotein E-deficient mice
... the expression of key hepatic genes in triglyceride formation and lipid clearance, which promotes FFA clearance from plasma and to decreased plasma FFAs ...severe atherosclerosis and unstable plaques in ... See full document
14
Differential effects of glyoxalase 1 overexpression on diabetic atherosclerosis and renal dysfunction in streptozotocin treated, apolipoprotein E deficient mice
... / mice was lar- gely prevented by the human GLO1 transgene and this was associated with reduced mesangial sclerosis and albu- .../ mice with respect to non- diabetic ...GLUT1 expression in the kidney ... See full document
18
The effects of total lymphocyte deficiency on the extent of atherosclerosis in apolipoprotein E / mice
... The effect of total lymphocyte deficiency on atherogenesis was investigated by crossing apo E-deficient mice (which develop atherosclerosis resembling human disease) with mice ... See full document
7
Hypercholesterolemia promotes early renal dysfunction in apolipoprotein E-deficient mice
... ApoE mice [18], renal histology analysis showed a marked mesangial expansion in young ApoE mouse, which could be favored by the increased leuko- cyte migration through glomerular capillaries [19] in response to ... See full document
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