[PDF] Top 20 Celastrol inhibits colorectal cancer through TGF-β1/Smad signaling
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Celastrol inhibits colorectal cancer through TGF-β1/Smad signaling
... (GAPDH, 1:5,000; TGF- β 1, 1:1,000; TGF β RI, 1:1,000; TGF β RII, 1:1,000; Smad2/3, 1:500; p-Smad2/3, 1:500; and Smad4, 1:500) at 4 ° C for ... See full document
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<p>Paeonol Inhibits Pancreatic Cancer Cell Migration and Invasion Through the Inhibition of TGF-β1/Smad Signaling and Epithelial-Mesenchymal-Transition</p>
... The TGF- β 1/Smad signaling pathway is involved in many diseases, including cardiovascular diseases, neurologi- cal disorders and ...igenesis, TGF- β 1 acts as a tumour ... See full document
11
<p>Overexpression of lncRNA NLIPMT Inhibits Colorectal Cancer Cell Migration and Invasion by Downregulating TGF-β1</p>
... Cells harvested at 24 h post-transfection were counted, and 3×10 4 cells were mixed with 1 mL aforementioned cell culture medium (serum-free) to prepare single cell suspen- sions. Transwell assays were performed ... See full document
8
TGF-β induced TMEPAI/PMEPA1 inhibits canonical Smad signaling through R-Smad sequestration and promotes non-canonical PI3K/Akt signaling by reducing PTEN in triple negative breast cancer
... Interestingly, TGF-β treatment caused increased association of NEDD4 with its antibody as well as TMEPAI, while PTEN disappeared from this complex presumably because of its ... See full document
17
Xiaokeping mixture inhibits diabetic nephropathy in streptozotocin-induced rats through blocking TGF-β1/Smad7 signaling
... After 1 week adaptation, the rats were divided into a normal control group (NC, n = 12) that was fed a standard diet and a high-fat (HF) group that received HF diet (con- taining ... See full document
6
SALL4 activates TGF-β/SMAD signaling pathway to induce EMT and promote gastric cancer metastasis
... of TGF- β 1 in the oncogenic roles of SALL4 in gastric cancer, we depleted TGF- β 1 expression in SALL4-overexpressing HGC-27 cells by using ...of TGF- β 1 gene knockdown ... See full document
12
Schisandrin B attenuates CCl<span style="font-size: 8.33333px">4</span>-induced liver fibrosis in rats by regulation of Nrf2-ARE and TGF-β/Smad signaling pathways
... B inhibits HSC activation. HSCs are activated by several cytokines, and TGF- β is considered as the most potent profibrogenic cytokine in the development of liver ...ng/mL TGF- β 1, as ... See full document
13
Original Article Effect of the traditional Chinese medicine Weifuchun on regulating atrophic gastritis through RUNX3/TGF-beta/Smad signaling pathway
... [10-12]. TGF-β2 is a secreted protein known as a cytokine that performs many ce- llular functions and has a vital role during embryonic development ...to TGF-β2 involves the Smad- dependent ... See full document
8
HOXC6 gene silencing inhibits epithelial-mesenchymal transition and cell viability through the TGF-β/smad signaling pathway in cervical carcinoma cells
... prostate cancer s ...in TGF-β/bone morphogenetic pro- tein pathway ...(TGF-β) signaling pathway plays an essential role in many devel- opment processes in human and animals [16], and it has ... See full document
16
<p>Exosomes derived from HCC cells with different invasion characteristics mediated EMT through TGF-β/Smad signaling pathway</p>
... lung cancer cells; co-culture of exosomes derived from cells induced by TGF- β with epithelial phenotypic cells revealed changes in the morphological and phenotypic marker proteins of recipient ...EMT ... See full document
9
Genetic depletion and pharmacological targeting of αv integrin in breast cancer cells impairs metastasis in zebrafish and mouse xenograft models
... breast cancer metastasis in a zebrafish model GLPG0187 is a recently developed non-peptide RGD antagonist, which inhibits αv integrin-ligand interactions ...or 1 ng/ml GLPG0187 did not change the ... See full document
16
Downregulation of miR-542-3p promotes cancer metastasis through activating TGF-β/Smad signaling in hepatocellular carcinoma
... of TGF- β 1/ Smad signaling pathway, was assessed by Western ...Eventually, TGF- β 1 (5 ng/mL; Abcam) can restore the inhibition of inva- sion phenotype and EMT markers induced ... See full document
11
<p>G3BP1 activates the TGF-β/Smad signaling pathway to promote gastric cancer</p>
... Gastric cancer (GC) is one of the most common malignancies of the digestive ...tract. 1 Although the incidence of GC has decreased in recent years, its mortality rate remains ... See full document
8
<p>HOXD9 Activates the TGF-β/Smad Signaling Pathway to Promote Gastric Cancer</p>
... discovered through reverse transcription- polymerase chain reaction (RT-PCR) that HOXD9 was highly expressed in cervical cancer cells, but not in normal cervical ...samples through IHC and found that ... See full document
10
Attenuation of myocardial fibrosis with curcumin is mediated by modulating expression of angiotensin II AT1/AT2 receptors and ACE2 in rats
... type 1 (AT1) receptor was reduced, and the Ang II type 2 (AT2) receptor was up-regulated, evidenced by an increased ratio of the AT2 receptor over the AT1 receptor in the curcumin group ...factor beta ... See full document
12
A taste of TGFβ in Tuscany
... for TGF ligands and add an additional inhibitory input in the TGF ...factor signaling through receptor tyrosine kinase receptors, TGF signaling is activated rather slowly; it ... See full document
5
Abstract: Crosstalk between the BMP and TGF- signaling pathways regulates many complex
... Estrogen inhibits transforming growth factor beta signaling by. 223[r] ... See full document
11
TGF β antagonists: Why suppress a tumor suppressor?
... drug. Both groups also addressed the mechanisms of action of Fc:TβRII in attenuating metastatic spread. In the MMTV-PyV mT model, Muraoka et al. (7) specifically exclude an effect on TGF-β–induced angiogenesis. In ... See full document
5
Original Article Triptolide inhibits lipopolysaccharide-induced proliferation, induces apoptosis and causes cell cycle arrest of human mesangial cells in vitro
... achieved through the cell cycle. As the cell cycle progresses, cells in G 1 -S phase enter G 2 phase, and mitosis occurs in M pha- ...G 1 phase ...G 1 phase, inhibiting ... See full document
11
The Role of p62/SQSTM1 in TGFβ-dependent EMT and Autophagy
... is Smad Anchor for Receptor Activation ...the Smad complex (Padua & Massagué, 2009). Smad nuclear import involves the nuclear localization sequence of Smads 2/3 as well as the importin nuclear ... See full document
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